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OBERON SIGNED

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

Total Cost €

EC-Contrib. €

Partnership

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OBERON project word cloud

Explore the words cloud of the OBERON project. It provides you a very rough idea of what is the project "OBERON" about.

mechanistic submitted relevance critical interdisciplinary inter metabolic nowadays cells oecd regulatory alternative union substances performance jrc acceptable validating experimental battery human deciphering validation covered computational throughput functional ed 3d vitro tissues select toxicity endocrine disorders disruptors silico stages outcome vivo community data ring strategy zebrafish detect consumers oberon disrupting conceptual metabolism 2d laboratory iata health tests eds biology endpoints omics public validated models threats chemical detection line biomonitoring combine epidemiology reduce technologies adverse aops levels exposure framework assays

Project "OBERON" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	6˙745˙894 €
EC max contribution	5˙978˙762 € (89%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2018-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	1˙900˙553.00
2	ARISTOTELIO PANEPISTIMIO THESSALONIKIS ARISTOTELIO PANEPISTIMIO THESSALONIKIS Organization address address: KEDEA BUILDING, TRITIS SEPTEMVRIOU, ARISTOTLE UNIV CAMPUS city: THESSALONIKI postcode: 54636 website: www.auth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (THESSALONIKI)	participant	793˙725.00
3	ENVE.X SINGLE MEMBER PC ENVE.X SINGLE MEMBER PC Organization address address: KOSTI PALAMA 11 city: THESALONIKI postcode: 551 33 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (THESALONIKI)	participant	610˙000.00
4	INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS Organization address address: Parc Technologique Alata city: VERNEUIL EN HALATTE postcode: 60550 website: www.ineris.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VERNEUIL EN HALATTE)	participant	558˙945.00
5	FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA Organization address address: C ROSSELLO 132 PLANTA 05 city: BARCELONA postcode: 8036 website: www.isglobal.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	550˙366.00
6	INSERM TRANSFERT SA INSERM TRANSFERT SA Organization address address: RUE WATT 7 city: PARIS postcode: 75013 website: www.inserm-transfert.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	379˙750.00
7	Masarykova univerzita Masarykova univerzita Organization address address: Zerotinovo namesti 9 city: BRNO STRED postcode: 60177 website: http://www.muni.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (BRNO STRED)	participant	330˙407.00
8	ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI Organization address address: VIA MARIO NEGRI 2 city: MILANO postcode: 20156 website: www.marionegri.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	304˙000.00
9	UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE Organization address address: AVENIDA DE LA UNIVERSIDAD S-N city: ELCHE postcode: 3202 website: www.umh.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (ELCHE)	participant	259˙706.00
10	BIOFYZIKALNI USTAV AKADEMIE VED CESKE REPUBLIKY BIOFYZIKALNI USTAV AKADEMIE VED CESKE REPUBLIKY Organization address address: Kralovopolska 135 city: Brno postcode: CZ-61265 website: http://www.ibp.cz/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (Brno)	participant	215˙250.00
11	AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL Organization address address: 14 RUE PIERRE ET MARIE CURIE city: MAISONS ALFORT postcode: 94700 website: www.anses.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (MAISONS ALFORT)	participant	76˙058.00
12	METABOLOMIC DISCOVERIES GMBH METABOLOMIC DISCOVERIES GMBH Organization address address: AM MUHLENBERG 11 city: POTSDAM postcode: 14476 website: www.metabolomicdiscoveries.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (POTSDAM)	participant	0.00

Map

Project objective

Exposure to chemical substances that can produce endocrine disrupting effects represents one of the most critical public health threats nowadays. In line with the regulatory framework implemented within the European Union to reduce the levels of endocrine disruptors (EDs) for consumers, new and effective methods for ED testing are needed. The OBERON project will build an integrated testing strategy (ITS) to detect EDs-related metabolic disorders by developing, improving and validating a battery of test systems. It will be based on the concept of an integrated approach for testing and assessment (IATA). OBERON will combine 1) experimental methods (in vitro e.g. on 2D and 3D human-derived cells and tissues, and in vivo i.e. in zebrafish at different stages), 2) high throughput omics technologies, 3) epidemiology and human biomonitoring studies and 4) advanced computational models (in silico and systems biology) on functional endpoints related to metabolism. Such interdisciplinary framework will help at deciphering EDs based on mechanistic understanding of toxicity by providing and making available more effective alternative test methods relevant for human health that are in line with regulatory needs. Data generated in OBERON will also allow the development of novel Adverse Outcome Pathways (AOPs). The assays will be pre-validated in order to select the test systems that will show acceptable performance in terms of relevance for the second step of the validation process, i.e. the inter-laboratory validation as ring tests. Therefore, the aim of the OBERON project is to support the OECD conceptual framework for testing and assessment of EDs by developing specific assays not covered by the current tests, and to propose an IATA approach for ED-related metabolic disorders detection, which will be submitted to the JRC and OECD community.

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The information about "OBERON" are provided by the European Opendata Portal: CORDIS opendata.