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OLEFINE SIGNED

OLEAginous yeast platforms for FINE chemicals

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

OLEFINE project word cloud

Explore the words cloud of the OLEFINE project. It provides you a very rough idea of what is the project "OLEFINE" about.

full added insect disrupting lifted trl7 efficiency academic life rapid least validate business market optimizing substitutes pest cascading plans line olefine downstream strains vision biological cheaper cell environmental create industrial employing optimize relation commercialize yeast innovative safe techno optimized biotech biocatalyst toxic joint summary environment fermentation prepared economic cycle jobs insecticide demonstrating sustainability environmentally chemicals pheromone engaged validated sustainable pheromones factories expansion post viability 75 oleaginous replacements

Project "OLEFINE" data sheet

The following table provides information about the project.

Coordinator	DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://www.olefine.eu
Total cost	7˙606˙556 €
EC max contribution	5˙442˙844 € (72%)
Programme	1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
Code Call	H2020-NMBP-BIO-2017
Funding Scheme	IA
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	coordinator	432˙287.00
2	BIOPHERO APS BIOPHERO APS Organization address address: DIPLOMVEJ 378 city: KONGENS LYNGBY postcode: 2800 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KONGENS LYNGBY)	participant	2˙025˙439.00
3	LUNDS UNIVERSITET LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LUND)	participant	1˙129˙112.00
4	BIOTREND-INOVACAO E ENGENHARIA EM BIOTECNOLOGIA SA BIOTREND-INOVACAO E ENGENHARIA EM BIOTECNOLOGIA SA Organization address address: BIOCANT PARK NUCLEO 4 LOTE 2 city: CANTANHEDE postcode: 3060-197 website: www.biotrend.biz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (CANTANHEDE)	participant	485˙956.00
5	"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" Organization address address: END OF PATRIARCHOU GRIGORIOU E AND 27 NEAPOLEOS STREET city: AGIA PARASKEVI postcode: 15341 website: www.demokritos.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (AGIA PARASKEVI)	participant	441˙311.00
6	THE UNIVERSITY OF MANCHESTER THE UNIVERSITY OF MANCHESTER Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL website: www.manchester.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	participant	250˙070.00
7	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	250˙000.00
8	THE UNIVERSITY OF LIVERPOOL THE UNIVERSITY OF LIVERPOOL Organization address address: BROWNLOW HILL 765 FOUNDATION BUILDING city: LIVERPOOL postcode: L69 7ZX website: www.liverpool.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LIVERPOOL)	participant	248˙070.00
9	NOVAGRICA HELLAS ANONIMI EMPORIKI EXAGOGIKI KAI SYMVOULEFTIKI ETAIRIA BIOLOGIKON KAI CHIMIKON PROIONTON NOVAGRICA HELLAS ANONIMI EMPORIKI EXAGOGIKI KAI SYMVOULEFTIKI ETAIRIA BIOLOGIKON KAI CHIMIKON PROIONTON Organization address address: GRAVIAS 10-12 city: ATHINA postcode: 10678 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	180˙596.00
10	ISCA TECHNOLOGIES, INC ISCA TECHNOLOGIES, INC Organization address address: 1230 SPRING STREET city: RIVERSIDE postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (RIVERSIDE)	participant	0.00

Map

Project objective

The academic and industrial partners engaged in the OLEFINE project have the joint vision of demonstrating the techno-economic viability and sustainability of biological production of insect pheromones for use as safe and environmentally friendly insecticide substitutes. Biological production of cheaper pheromones will be a market disrupting technology that will allow rapid expansion of pheromone-based pest management products. The partners behind OLEFINE have developed a novel technology for biological production of pheromones using oleaginous yeast cell factories, however the strains, fermentation, and downstream process need to be further optimized to bring the technology to the market. OLEFINE aims to optimize, validate, and commercialize biotech process for production of high-added-value chemicals (insect pheromones) for use as non-toxic insecticide replacements. Cost-efficiency and sustainability of the current process will be lifted in this project by optimizing the yeast biocatalyst and by employing innovative fermentation and downstream processing with cascading of resources. The production cost will be reduced by at least 75% in relation to the current state-of-the-art. The process will be validated in industrial environment for two pheromones (TRL7), techno-economic viability will be estimated and business plans will be prepared. The environmental impact and sustainability will be evaluated by full Life Cycle Analysis. The technology will be brought to the market by OLEFINE industrial partners post project. In summary, OLEFINE will bring new sustainable high-value chemicals to the market and create new business opportunities and jobs in European biotech sector, which is in line with the challenge of the topic.

Publications

List of publications.
year	authors and title	journal	last update
2018	Carina Holkenbrink, Marie I. Dam, Kanchana R. Kildegaard, Johannes Beder, Jonathan Dahlin, David DomÃ©nech Belda, Irina Borodina EasyCloneYALI: CRISPR/Cas9-Based Synthetic Toolbox for Engineering of the Yeast Yarrowia lipolytica published pages: 1700543, ISSN: 1860-6768, DOI: 10.1002/biot.201700543	Biotechnology Journal 13/9	2020-01-16

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