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CANCER SIGNED

Personalised Postoperative Immunotherapy To Improving Cancer Outcome and improving quality of life

Total Cost €

EC-Contrib. €

Partnership

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CANCER project word cloud

Explore the words cloud of the CANCER project. It provides you a very rough idea of what is the project "CANCER" about.

function months immune tumour surgical micrometastases techniques forms treatment multidisciplinary gene protection directions inability monitor latent modulating image multiplexed aggressive chemotherapy strategy option mouse disease conjunction implementing lack encapsulate radiation effectiveness during postoperative platform implies cancer events optimise solid biomolecules accurate distal transgenic types combinations components libraries lifetime intended signatures observation encapsulated tissues interactions starts resides immunotherapeutic reagent profiles surgery guided therapeutic visualised models personalised ultimately mass metastatic platforms initial progression accessible relapse underlie limitations healthy followed payload time nanoparticle radiotherapy tumours biomarkers curative identification therapy body efficacy toxicity immunotherapy resection

Project "CANCER" data sheet

The following table provides information about the project.

Coordinator	PERCUROS BV Organization address address: PLESMANLAAN 1 city: LEIDEN postcode: 2333 BZ website: www.percuros.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	2˙430˙000 €
EC max contribution	2˙430˙000 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2017
Funding Scheme	MSCA-RISE
Starting year	2018
Duration (year-month-day)	from 2018-03-01 to 2022-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	PERCUROS BV PERCUROS BV Organization address address: PLESMANLAAN 1 city: LEIDEN postcode: 2333 BZ website: www.percuros.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	coordinator	378˙000.00
2	ASSOCIAZIONE HAND IN HAND ASSOCIAZIONE HAND IN HAND Organization address address: PIAZZA ROMA 2 city: NEMI postcode: 74 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (NEMI)	participant	216˙000.00
3	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	162˙000.00
4	HELRIK AND LOUW AND PARTNERS COMPANY LTD HELRIK AND LOUW AND PARTNERS COMPANY LTD Organization address address: 72 GREAT SUFFOLK STREET city: LONDON postcode: SE1 0BL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	162˙000.00
5	TECOBIOSCIENCES GMBH TECOBIOSCIENCES GMBH Organization address address: HABICHTSTRASSE 21 city: LANDSHUT postcode: 84036 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LANDSHUT)	participant	162˙000.00
6	AUGEAS ASSOCIAZIONE DI SPORT PROMOZIONE E TURISMO AUGEAS ASSOCIAZIONE DI SPORT PROMOZIONE E TURISMO Organization address address: VICOLO DELLE SCALETTE 6 city: NEMI postcode: 40 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (NEMI)	participant	108˙000.00
7	BOSCHIVA MELCHIORRI SRL BOSCHIVA MELCHIORRI SRL Organization address address: VIA DI BARBAROSSA 18 city: ROCCA DI PAPA postcode: 40 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROCCA DI PAPA)	participant	108˙000.00
8	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	108˙000.00
9	JENACELL GMBH JENACELL GMBH Organization address address: GOSCHWITZER STR. 22 city: JENA postcode: 7745 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (JENA)	participant	108˙000.00
10	MEDRES-MEDICAL RESEARCH GMBH MEDRES-MEDICAL RESEARCH GMBH Organization address address: GLEUELER STRASSE 50 city: KOLN postcode: 50931 website: www.medres.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOLN)	participant	108˙000.00
11	PROGREDUM GMBH PROGREDUM GMBH Organization address address: OTTERBERGER STRASSE 73 city: KAISERSLAUTERN postcode: 67659 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KAISERSLAUTERN)	participant	108˙000.00
12	TECHNISCHE UNIVERSITEIT DELFT TECHNISCHE UNIVERSITEIT DELFT Organization address address: STEVINWEG 1 city: DELFT postcode: 2628 CN website: www.tudelft.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DELFT)	participant	108˙000.00
13	THE UNIVERSITY OF SHEFFIELD THE UNIVERSITY OF SHEFFIELD Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SHEFFIELD)	participant	108˙000.00
14	UNIVERSITA DEGLI STUDI DI CAMERINO UNIVERSITA DEGLI STUDI DI CAMERINO Organization address address: PIAZZA CAVOUR 19F city: CAMERINO postcode: 62032 website: www.unicam.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CAMERINO)	participant	108˙000.00
15	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	108˙000.00
16	UNIVERSITEIT VAN AMSTERDAM UNIVERSITEIT VAN AMSTERDAM Organization address address: SPUI 21 city: AMSTERDAM postcode: 1012WX website: www.uva.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	108˙000.00
17	UNIWERSYTET JAGIELLONSKI UNIWERSYTET JAGIELLONSKI Organization address address: Ul. Golebia 24 city: KRAKOW postcode: 31007 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (KRAKOW)	participant	108˙000.00
18	ASSOCIAZIONE CULTURALE CASTELLI ROMANI GREEN TOUR ASSOCIAZIONE CULTURALE CASTELLI ROMANI GREEN TOUR Organization address address: VIA DEL PARCO 3 city: ARICCIA postcode: 72 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ARICCIA)	participant	54˙000.00
19	HELRIK AND LOUW COMPANY LTD HELRIK AND LOUW COMPANY LTD Organization address address: 72 GREAT SUFFOLK STREET city: LONDON postcode: SE1 0BL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	0.00

Map

Project objective

During this RISE project we aim to develop nanoparticle-based encapsulated libraries of different immunotherapeutic biomolecules for treatment after surgery as part of a novel cancer management strategy. The current state-of-art for the management of cancer starts with surgery, after identification of an accessible tumour mass. Surgery remains an effective treatment option for many types of cancer today and it is considered curative treatment for most solid tumours. It forms part of a multidisciplinary approach used in conjunction with radiotherapy or chemotherapy. These approaches, however, have several limitations, including inability of surgical resection to affect distal metastatic disease, toxicity to healthy tissues with chemotherapy and lack of effectiveness of radiation therapy in more aggressive tumours. The observation that cancer can relapse months or years after initial surgery implies that micrometastases still resides within the body in a latent state. Our proposal is to take cancer therapy to beyond state-of-art by implementing techniques which will take us into new directions. This includes a) new methods to identify immune gene profiles and biomarkers b) transgenic mouse models where the complex interactions that underlie immune function can be visualised as multiplexed events in real time and c) the use of nanoparticle-based libraries of immune modulating reagent combinations. There are three key objectives within this project: i) to use immune gene signatures to monitor disease progression and therapeutic efficacy of immunotherapy combinations on nanoparticle-based platforms, ii) to optimise the platform to encapsulate libraries of immune components for more personalised, accurate and timely delivery of the payload to its intended target and iii) to optimise the overall cancer management process of image-guided surgery followed by postoperative immunotherapy so that we can ultimately provide a lifetime of protection against cancer.

Deliverables

List of deliverables.
Established network organisation and management structure	Documents, reports	2020-02-13 13:09:04
Annual gender equality monitoring	Documents, reports	2020-02-13 13:09:04

Take a look to the deliverables list in detail: detailed list of CANCER deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Chih Kit Chung, Marieke F. Fransen, Koen van der Maaden, Yaima Campos, Jomarien GarcÃa-Couce, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies published pages: , ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2020.03.050	Journal of Controlled Release	2020-04-15
2020	Giuseppina Roscigno, Assunta Cirella, Alessandra Affinito, Cristina Quintavalle, Iolanda Scognamiglio, Francesco Palma, Francesco Ingenito, Silvia Nuzzo, Francesca De Micco, Antonio Cuccuru, Renato Thomas, Gerolama Condorelli miR-216a Acts as a Negative Regulator of Breast Cancer by Modulating Stemness Properties and Tumor Microenvironment published pages: 2313, ISSN: 1422-0067, DOI: 10.3390/ijms21072313	International Journal of Molecular Sciences 21/7	2020-04-07
2020	Ana Luiza C. de S. L. Oliveira, Raimundo Fernandes de AraÃºjo JÃºnior, ThaÃs Gomes de Carvalho, Alan B. Chan, Timo Schomann, Filippo Tamburini, Lioe-Fee de Geus-Oei, Luis J. Cruz Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer published pages: 193, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics12020193	Pharmaceutics 12/2	2020-04-01
2020	Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17Î±-Methyltestosterone Delivery published pages: 1181, ISSN: 1420-3049, DOI: 10.3390/molecules25051181	Molecules 25/5	2020-04-01
2020	Alessandra Affinito, Cristina Quintavalle, Carla Lucia Esposito, Giuseppina Roscigno, Catello Giordano, Silvia Nuzzo, Lucia Ricci-Vitiani, Iolanda Scognamiglio, Zoran Minic, Roberto Pallini, Maxim V. Berezovski, Vittorio de Francisis, Gerolama Condorelli Targeting Ephrin Receptor Tyrosine Kinase A2 with a Selective Aptamer for Glioblastoma Stem Cells published pages: 176-185, ISSN: 2162-2531, DOI: 10.1016/j.omtn.2020.02.005	Molecular Therapy - Nucleic Acids 20	2020-04-01
2019	C.G. Da Silva, M.G.M. Camps, T.M.W.Y. Li, A.B. Chan, F. Ossendorp, L.J. Cruz Co-delivery of immunomodulators in biodegradable nanoparticles improves therapeutic efficacy of cancer vaccines published pages: 119417, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.119417	Biomaterials 220	2020-03-05
2019	Dana Kralisch, Uwe Beekmann Bacterial cellulose product design towards biomedical and diagnostic applications published pages: , ISSN: , DOI:		2020-03-05
2020	Jian Yang, Yangyang Zhao, Yangqi Meng, Hancheng Zhu, Duanting Yan, Chunguang Liu, Changshan Xu, Hong Zhang, Lin Xu, Yuxin Li, Yuxue Liu Irradiation-free photodynamic therapy in vivo induced by enhanced deep red afterglow within NIR-I bio-window published pages: 124067, ISSN: 1385-8947, DOI: 10.1016/j.cej.2020.124067	Chemical Engineering Journal 387	2020-03-05
2019	Yansong Feng, Yanni Wu, Jing Zuo, Langping Tu, Ivo Que, Yulei Chang, Luis J. Cruz, Alan Chan, Hong Zhang Assembly of upconversion nanophotosensitizer in vivo to achieve scatheless real-time imaging and selective photodynamic therapy published pages: 33-41, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.02.015	Biomaterials 201	2020-03-05
2018	Yadan Ding Construction and Optimization of Biofunctional Upconversion Nanoplatforms published pages: , ISSN: , DOI:		2020-02-20
2019	Silvia Nuzzo, Giuseppina Roscigno, Alessandra Affinito, Francesco Ingenito, Cristina Quintavalle, Gerolama Condorelli Potential and Challenges of Aptamers as Specific Carriers of Therapeutic Oligonucleotides for Precision Medicine in Cancer published pages: 1521, ISSN: 2072-6694, DOI: 10.3390/cancers11101521	Cancers 11/10	2020-02-20
2018	Bartosz KlÄ™bowski, Joanna Depciuch, Magdalena ParliÅ„ska-Wojtan, Jarek Baran Applications of Noble Metal-Based Nanoparticles in Medicine published pages: 4031, ISSN: 1422-0067, DOI: 10.3390/ijms19124031	International Journal of Molecular Sciences 19/12	2020-02-20
2019	Dimitrios Agas, Fulvio Laus, Giovanna Lacava, Andrea Marchegiani, Siyuan Deng, Federico Magnoni, Guilherme GusmÃ£o Silva, Piera Di Martino, Maria Giovanna Sabbieti, Roberta Censi Thermosensitive hybrid hyaluronan/p(HPMAmâ€lac)â€PEG hydrogels enhance cartilage regeneration in a mouse model of osteoarthritis published pages: 20013-20027, ISSN: 0021-9541, DOI: 10.1002/jcp.28598	Journal of Cellular Physiology 234/11	2020-02-20
2018	Roberta Censi, Maria Gigliobianco, Cristina Casadidio, Piera Di Martino Hot Melt Extrusion: Highlighting Physicochemical Factors to Be Investigated While Designing and Optimizing a Hot Melt Extrusion Process published pages: 89, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics10030089	Pharmaceutics 10/3	2020-02-20
2019	Luis J. Cruz, Paul J. Tacken, Johan M.S. van der Schoot, Felix Rueda, Ruurd Torensma, Carl G. Figdor ICAM3-Fc Outperforms Receptor-Specific Antibodies Targeted Nanoparticles to Dendritic Cells for Cross-Presentation published pages: 1825, ISSN: 1420-3049, DOI: 10.3390/molecules24091825	Molecules 24/9	2020-02-20
2020	Yansong Feng, Haoran Chen, Yanni Wu, Ivo Que, Filippo Tamburini, Fabio Baldazzi, Yulei Chang, Hong Zhang Optical imaging and pH-awakening therapy of deep tissue cancer based on specific upconversion nanophotosensitizers published pages: 119637, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.119637	Biomaterials 230	2020-02-20
2019	Candido G. Da Silva, Marcel G.M. Camps, Tracy M.W.Y. Li, Luana Zerrillo, Clemens W. LÃ¶wik, Ferry Ossendorp, Luis J. Cruz Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles published pages: 6485-6500, ISSN: 1838-7640, DOI: 10.7150/thno.34429	Theranostics 9/22	2020-02-13
2019	Manuela Cortese, Maria Rosa Gigliobianco, Dolores Vargas Peregrina, Gianni Sagratini, Roberta Censi, Piera Di Martino Quantification of phenolic compounds in different types of crafts beers, worts, starting and spent ingredients by liquid chromatography-tandem mass spectrometry published pages: 460622, ISSN: 0021-9673, DOI: 10.1016/j.chroma.2019.460622	Journal of Chromatography A	2020-02-13
2019	L. Zerrillo, I. Que, O. Vepris, L.N. Morgado, A. Chan, K. Bierau, Y. Li, F. Galli, E. Bos, R. Censi, P. Di Martino, G.J.V.M. van Osch, L.J. Cruz pH-responsive poly(lactide-co-glycolide) nanoparticles containing near-infrared dye for visualization and hyaluronic acid for treatment of osteoarthritis published pages: 265-276, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.07.031	Journal of Controlled Release 309	2020-02-13
2019	Yaima Campos, Amisel Almirall, GastÃ³n Fuentes, Hans L. Bloem, Eric L. Kaijzel, Luis J. Cruz Tissue Engineering: An Alternative to Repair Cartilage published pages: 357-373, ISSN: 1937-3368, DOI: 10.1089/ten.teb.2018.0330	Tissue Engineering Part B: Reviews 25/4	2020-02-13
2018	N De Vries, V Van Unen, T Abdelaal, M Van Herk, R Van der Breggen, A Farina Sarasqueta, T HÃ¶llt, B Lelieveldt, F Koning, N De Miranda Po-260 deep phenotyping of colorectal cancers by high-dimensional mass cytometry reveals tumor-specific immune landscapes published pages: A328.2-A329, ISSN: , DOI: 10.1136/esmoopen-2018-EACR25.775	Tumour Microenvironment	2020-02-13
2018	Irene Anton-Sales, Uwe Beekmann, Anna Laromaine, Anna Roig, Dana Kralisch Opportunities of bacterial cellulose to treat epithelial tissues published pages: 808-822, ISSN: 1389-4501, DOI: 10.2174/1389450120666181129092144	Current Drug Targets 20	2020-02-13
2018	Ming Yang, Daniel McKay, Jeffrey W. Pollard, Claire E. Lewis Diverse Functions of Macrophages in Different Tumor Microenvironments published pages: 5492-5503, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-18-1367	Cancer Research 78/19	2020-02-13
2018	Chih Kit Chung, C.G. Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences published pages: 56-66, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2018.07.011	Journal of Controlled Release 285	2020-02-13

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The information about "CANCER" are provided by the European Opendata Portal: CORDIS opendata.