Explore the words cloud of the CANCER project. It provides you a very rough idea of what is the project "CANCER" about.
The following table provides information about the project.
Coordinator |
PERCUROS BV
Organization address contact info |
Coordinator Country | Netherlands [NL] |
Total cost | 2˙430˙000 € |
EC max contribution | 2˙430˙000 € (100%) |
Programme |
1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge) |
Code Call | H2020-MSCA-RISE-2017 |
Funding Scheme | MSCA-RISE |
Starting year | 2018 |
Duration (year-month-day) | from 2018-03-01 to 2022-02-28 |
Take a look of project's partnership.
During this RISE project we aim to develop nanoparticle-based encapsulated libraries of different immunotherapeutic biomolecules for treatment after surgery as part of a novel cancer management strategy. The current state-of-art for the management of cancer starts with surgery, after identification of an accessible tumour mass. Surgery remains an effective treatment option for many types of cancer today and it is considered curative treatment for most solid tumours. It forms part of a multidisciplinary approach used in conjunction with radiotherapy or chemotherapy. These approaches, however, have several limitations, including inability of surgical resection to affect distal metastatic disease, toxicity to healthy tissues with chemotherapy and lack of effectiveness of radiation therapy in more aggressive tumours. The observation that cancer can relapse months or years after initial surgery implies that micrometastases still resides within the body in a latent state. Our proposal is to take cancer therapy to beyond state-of-art by implementing techniques which will take us into new directions. This includes a) new methods to identify immune gene profiles and biomarkers b) transgenic mouse models where the complex interactions that underlie immune function can be visualised as multiplexed events in real time and c) the use of nanoparticle-based libraries of immune modulating reagent combinations. There are three key objectives within this project: i) to use immune gene signatures to monitor disease progression and therapeutic efficacy of immunotherapy combinations on nanoparticle-based platforms, ii) to optimise the platform to encapsulate libraries of immune components for more personalised, accurate and timely delivery of the payload to its intended target and iii) to optimise the overall cancer management process of image-guided surgery followed by postoperative immunotherapy so that we can ultimately provide a lifetime of protection against cancer.
Established network organisation and management structure | Documents, reports | 2020-02-13 13:09:04 |
Annual gender equality monitoring | Documents, reports | 2020-02-13 13:09:04 |
Take a look to the deliverables list in detail: detailed list of CANCER deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2020 |
Chih Kit Chung, Marieke F. Fransen, Koen van der Maaden, Yaima Campos, Jomarien GarcÃa-Couce, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies published pages: , ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2020.03.050 |
Journal of Controlled Release | 2020-04-15 |
2020 |
Giuseppina Roscigno, Assunta Cirella, Alessandra Affinito, Cristina Quintavalle, Iolanda Scognamiglio, Francesco Palma, Francesco Ingenito, Silvia Nuzzo, Francesca De Micco, Antonio Cuccuru, Renato Thomas, Gerolama Condorelli miR-216a Acts as a Negative Regulator of Breast Cancer by Modulating Stemness Properties and Tumor Microenvironment published pages: 2313, ISSN: 1422-0067, DOI: 10.3390/ijms21072313 |
International Journal of Molecular Sciences 21/7 | 2020-04-07 |
2020 |
Ana Luiza C. de S. L. Oliveira, Raimundo Fernandes de Araújo Júnior, ThaÃs Gomes de Carvalho, Alan B. Chan, Timo Schomann, Filippo Tamburini, Lioe-Fee de Geus-Oei, Luis J. Cruz Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer published pages: 193, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics12020193 |
Pharmaceutics 12/2 | 2020-04-01 |
2020 |
Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery published pages: 1181, ISSN: 1420-3049, DOI: 10.3390/molecules25051181 |
Molecules 25/5 | 2020-04-01 |
2020 |
Alessandra Affinito, Cristina Quintavalle, Carla Lucia Esposito, Giuseppina Roscigno, Catello Giordano, Silvia Nuzzo, Lucia Ricci-Vitiani, Iolanda Scognamiglio, Zoran Minic, Roberto Pallini, Maxim V. Berezovski, Vittorio de Francisis, Gerolama Condorelli Targeting Ephrin Receptor Tyrosine Kinase A2 with a Selective Aptamer for Glioblastoma Stem Cells published pages: 176-185, ISSN: 2162-2531, DOI: 10.1016/j.omtn.2020.02.005 |
Molecular Therapy - Nucleic Acids 20 | 2020-04-01 |
2019 |
C.G. Da Silva, M.G.M. Camps, T.M.W.Y. Li, A.B. Chan, F. Ossendorp, L.J. Cruz Co-delivery of immunomodulators in biodegradable nanoparticles improves therapeutic efficacy of cancer vaccines published pages: 119417, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.119417 |
Biomaterials 220 | 2020-03-05 |
2019 |
Dana Kralisch, Uwe Beekmann Bacterial cellulose product design towards biomedical and diagnostic applications published pages: , ISSN: , DOI: |
2020-03-05 | |
2020 |
Jian Yang, Yangyang Zhao, Yangqi Meng, Hancheng Zhu, Duanting Yan, Chunguang Liu, Changshan Xu, Hong Zhang, Lin Xu, Yuxin Li, Yuxue Liu Irradiation-free photodynamic therapy in vivo induced by enhanced deep red afterglow within NIR-I bio-window published pages: 124067, ISSN: 1385-8947, DOI: 10.1016/j.cej.2020.124067 |
Chemical Engineering Journal 387 | 2020-03-05 |
2019 |
Yansong Feng, Yanni Wu, Jing Zuo, Langping Tu, Ivo Que, Yulei Chang, Luis J. Cruz, Alan Chan, Hong Zhang Assembly of upconversion nanophotosensitizer in vivo to achieve scatheless real-time imaging and selective photodynamic therapy published pages: 33-41, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.02.015 |
Biomaterials 201 | 2020-03-05 |
2018 |
Yadan Ding Construction and Optimization of Biofunctional Upconversion Nanoplatforms published pages: , ISSN: , DOI: |
2020-02-20 | |
2019 |
Silvia Nuzzo, Giuseppina Roscigno, Alessandra Affinito, Francesco Ingenito, Cristina Quintavalle, Gerolama Condorelli Potential and Challenges of Aptamers as Specific Carriers of Therapeutic Oligonucleotides for Precision Medicine in Cancer published pages: 1521, ISSN: 2072-6694, DOI: 10.3390/cancers11101521 |
Cancers 11/10 | 2020-02-20 |
2018 |
Bartosz Klębowski, Joanna Depciuch, Magdalena Parlińska-Wojtan, Jarek Baran Applications of Noble Metal-Based Nanoparticles in Medicine published pages: 4031, ISSN: 1422-0067, DOI: 10.3390/ijms19124031 |
International Journal of Molecular Sciences 19/12 | 2020-02-20 |
2019 |
Dimitrios Agas, Fulvio Laus, Giovanna Lacava, Andrea Marchegiani, Siyuan Deng, Federico Magnoni, Guilherme Gusmão Silva, Piera Di Martino, Maria Giovanna Sabbieti, Roberta Censi Thermosensitive hybrid hyaluronan/p(HPMAmâ€lac)â€PEG hydrogels enhance cartilage regeneration in a mouse model of osteoarthritis published pages: 20013-20027, ISSN: 0021-9541, DOI: 10.1002/jcp.28598 |
Journal of Cellular Physiology 234/11 | 2020-02-20 |
2018 |
Roberta Censi, Maria Gigliobianco, Cristina Casadidio, Piera Di Martino Hot Melt Extrusion: Highlighting Physicochemical Factors to Be Investigated While Designing and Optimizing a Hot Melt Extrusion Process published pages: 89, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics10030089 |
Pharmaceutics 10/3 | 2020-02-20 |
2019 |
Luis J. Cruz, Paul J. Tacken, Johan M.S. van der Schoot, Felix Rueda, Ruurd Torensma, Carl G. Figdor ICAM3-Fc Outperforms Receptor-Specific Antibodies Targeted Nanoparticles to Dendritic Cells for Cross-Presentation published pages: 1825, ISSN: 1420-3049, DOI: 10.3390/molecules24091825 |
Molecules 24/9 | 2020-02-20 |
2020 |
Yansong Feng, Haoran Chen, Yanni Wu, Ivo Que, Filippo Tamburini, Fabio Baldazzi, Yulei Chang, Hong Zhang Optical imaging and pH-awakening therapy of deep tissue cancer based on specific upconversion nanophotosensitizers published pages: 119637, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.119637 |
Biomaterials 230 | 2020-02-20 |
2019 |
Candido G. Da Silva, Marcel G.M. Camps, Tracy M.W.Y. Li, Luana Zerrillo, Clemens W. Löwik, Ferry Ossendorp, Luis J. Cruz Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles published pages: 6485-6500, ISSN: 1838-7640, DOI: 10.7150/thno.34429 |
Theranostics 9/22 | 2020-02-13 |
2019 |
Manuela Cortese, Maria Rosa Gigliobianco, Dolores Vargas Peregrina, Gianni Sagratini, Roberta Censi, Piera Di Martino Quantification of phenolic compounds in different types of crafts beers, worts, starting and spent ingredients by liquid chromatography-tandem mass spectrometry published pages: 460622, ISSN: 0021-9673, DOI: 10.1016/j.chroma.2019.460622 |
Journal of Chromatography A | 2020-02-13 |
2019 |
L. Zerrillo, I. Que, O. Vepris, L.N. Morgado, A. Chan, K. Bierau, Y. Li, F. Galli, E. Bos, R. Censi, P. Di Martino, G.J.V.M. van Osch, L.J. Cruz pH-responsive poly(lactide-co-glycolide) nanoparticles containing near-infrared dye for visualization and hyaluronic acid for treatment of osteoarthritis published pages: 265-276, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.07.031 |
Journal of Controlled Release 309 | 2020-02-13 |
2019 |
Yaima Campos, Amisel Almirall, Gastón Fuentes, Hans L. Bloem, Eric L. Kaijzel, Luis J. Cruz Tissue Engineering: An Alternative to Repair Cartilage published pages: 357-373, ISSN: 1937-3368, DOI: 10.1089/ten.teb.2018.0330 |
Tissue Engineering Part B: Reviews 25/4 | 2020-02-13 |
2018 |
N De Vries, V Van Unen, T Abdelaal, M Van Herk, R Van der Breggen, A Farina Sarasqueta, T Höllt, B Lelieveldt, F Koning, N De Miranda Po-260 deep phenotyping of colorectal cancers by high-dimensional mass cytometry reveals tumor-specific immune landscapes published pages: A328.2-A329, ISSN: , DOI: 10.1136/esmoopen-2018-EACR25.775 |
Tumour Microenvironment | 2020-02-13 |
2018 |
Irene Anton-Sales, Uwe Beekmann, Anna Laromaine, Anna Roig, Dana Kralisch Opportunities of bacterial cellulose to treat epithelial tissues published pages: 808-822, ISSN: 1389-4501, DOI: 10.2174/1389450120666181129092144 |
Current Drug Targets 20 | 2020-02-13 |
2018 |
Ming Yang, Daniel McKay, Jeffrey W. Pollard, Claire E. Lewis Diverse Functions of Macrophages in Different Tumor Microenvironments published pages: 5492-5503, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-18-1367 |
Cancer Research 78/19 | 2020-02-13 |
2018 |
Chih Kit Chung, C.G. Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences published pages: 56-66, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2018.07.011 |
Journal of Controlled Release 285 | 2020-02-13 |
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The information about "CANCER" are provided by the European Opendata Portal: CORDIS opendata.