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INSPIRE SIGNED

INfraStructure in Proton International REsearch

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

INSPIRE project word cloud

Explore the words cloud of the INSPIRE project. It provides you a very rough idea of what is the project "INSPIRE" about.

area radical gateway radiation training databases government communicate worlds surrounding inspire give radiotherapy software pipeline eleven manufacturers environment dose patient countries delivering trans principles investment operation usa benefit energies capability healthy either minimal manufactures contain disciplinary sme damage huge conforming clinical proton integrating innovation exponentially national manufacturing industrial discipline unrivalled joint tumour tissue pbt transnational centres beams networking employing energy link accelerate hop causing heart integrates commercial brings offers therapy responsible beam

Project "INSPIRE" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF MANCHESTER Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL website: www.manchester.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	4˙999˙867 €
EC max contribution	4˙999˙867 € (100%)
Programme	1. H2020-EU.1.4.1.2. (Integrating and opening existing national and regional research infrastructures of European interest)
Code Call	H2020-INFRAIA-2017-1-two-stage
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-03-01 to 2022-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF MANCHESTER THE UNIVERSITY OF MANCHESTER Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL website: www.manchester.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	coordinator	1˙017˙344.00
2	PAUL SCHERRER INSTITUT PAUL SCHERRER INSTITUT Organization address address: FORSCHUNGSTRASSE 111 city: VILLIGEN PSI postcode: 5232 website: www.psi.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (VILLIGEN PSI)	participant	348˙798.00
3	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	participant	345˙637.00
4	KOMMUNALFORBUNDET AVANCERAD STRALBEHANDLING KOMMUNALFORBUNDET AVANCERAD STRALBEHANDLING Organization address address: VON KRAEMERS ALLE 26 city: UPPSALA postcode: 752 37 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	participant	338˙637.00
5	INSTITUT CURIE INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	333˙632.00
6	GSI HELMHOLTZZENTRUM FUER SCHWERIONENFORSCHUNG GMBH GSI HELMHOLTZZENTRUM FUER SCHWERIONENFORSCHUNG GMBH Organization address address: PLANCKSTRASSE 1 city: DARMSTADT postcode: 64291 website: http://www.gsi.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DARMSTADT)	participant	308˙250.00
7	TECHNISCHE UNIVERSITAET DRESDEN TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	participant	294˙516.00
8	ACADEMISCH ZIEKENHUIS GRONINGEN ACADEMISCH ZIEKENHUIS GRONINGEN Organization address address: HANZEPLEIN 1 city: GRONINGEN postcode: 9713 GZ website: www.umcg.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	261˙625.00
9	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	260˙202.00
10	USTAV JADERNE FYZIKY AV CR USTAV JADERNE FYZIKY AV CR Organization address address: Husinec - Å˜eÅ¾ 130 city: REZ - PRAHA postcode: 25068 website: www.ujf.cas.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (REZ - PRAHA)	participant	250˙450.00
11	THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS, POLISH ACADEMY OF SCIENCES THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS, POLISH ACADEMY OF SCIENCES Organization address address: RADZIKOWSKIEGO 152 city: KRAKOW postcode: 31 342 website: www.ifj.edu.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (KRAKOW)	participant	221˙899.00
12	ION BEAM APPLICATIONS SA ION BEAM APPLICATIONS SA Organization address address: CHEMIN DU CYCLOTRON 3 city: OTTIGNIES LOUVAIN LA NEUVE postcode: 1348 website: www.iba-group.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (OTTIGNIES LOUVAIN LA NEUVE)	participant	206˙497.00
13	VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH Organization address address: MOTTMANNSTRASSE 2 city: TROISDORF postcode: 53842 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (TROISDORF)	participant	204˙071.00
14	INTERNET-SIMULATION EVALUATION ENVISION SRL INTERNET-SIMULATION EVALUATION ENVISION SRL Organization address address: VIA PIETRO GIURIA 1 city: TORINO postcode: 10125 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	201˙125.00
15	UNIVERSITE DE NAMUR ASBL UNIVERSITE DE NAMUR ASBL Organization address address: RUE DE BRUXELLES 61 city: NAMUR postcode: 5000 website: www.unamur.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (NAMUR)	participant	196˙870.00
16	LIETUVOS SVEIKATOS MOKSLU UNIVERSITETAS LIETUVOS SVEIKATOS MOKSLU UNIVERSITETAS Organization address address: A MICKEVICIAUS GATVE 9 city: KAUNAS postcode: 44307 website: www.lsmuni.lt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LT (KAUNAS)	participant	152˙123.00
17	THE CHRISTIE NHS FOUNDATION TRUST THE CHRISTIE NHS FOUNDATION TRUST Organization address address: WILMSLOW ROAD 1 city: MANCHESTER postcode: M20 4BX website: www.christie.nhs.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	participant	58˙185.00
18	ISTITUTO NAZIONALE DI FISICA NUCLEARE ISTITUTO NAZIONALE DI FISICA NUCLEARE Organization address address: Via Enrico Fermi 54 city: FRASCATI postcode: 44 website: www.infn.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (FRASCATI)	participant	0.00

Map

Project objective

Proton beam therapy (PBT) is a radical new type of advanced radiotherapy, capable of delivering and conforming a targeted dose of radiation to the tumour while causing minimal damage to the surrounding healthy tissue. In the past 5 years there has been a huge investment in high energy PBT across Europe and eleven member states now either have PBT in operation or are developing this capability. In addition, the two largest manufactures of PBT equipment have based their manufacturing in Europe. This integrating activity INSPIRE, aims to link these clinical PBT centres in eleven different countries together with two associated centres in USA. It also brings in two of the worlds largest manufacturers of PBT equipment and an SME. The trans-national access in INSPIRE will provide European researchers with access to “state of the art” research capabilities employing proton beams at clinical energies. INSPIRE represents an integrating activity across Europe in a multi-disciplinary field that is growing exponentially. Through its Networking, Transnational Access and Joint Research Activities, INSPIRE seeks to provide the “state of the art” capabilities that are needed to address the key challenges in this rapidly developing field. INSPIRE has at its heart the principles of responsible research and innovation and will communicate its research and give access to its databases and software through an Open Access Gateway. INSPIRE will contain a pipeline of innovation through its Innovation Gateway, to accelerate research for patient and commercial benefit. INSPIRE will provide its researchers with an unrivalled research and training and opportunities to “discipline hop” into the industrial, clinical or industrial environment. INSPIRE integrates activities across Europe in this rapidly growing area and offers European researchers unrivalled access to state of the art research capabilities in an area where there has already been significant government investment.

Deliverables

List of deliverables.
User selection Panel appointed	Other	2020-03-23 17:36:32
Access Gateway designed and launched	Websites, patent fillings, videos etc.	2020-03-23 17:36:32
Open Nights programme commenced	Other	2020-03-23 17:36:32
TNA providers have QA documentation in place	Documents, reports	2020-03-23 17:36:32
Incorporation of PBT indications into Malthus decision trees	Demonstrators, pilots, prototypes	2020-03-23 17:36:32
Definition of key parameters for NTCP based patient selection and tumour sites	Documents, reports	2020-03-23 17:36:32

Take a look to the deliverables list in detail: detailed list of INSPIRE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	M. Tambas, H.P. van der Laan, A.V.D. Hoek, H.P. Bijl, M. Dieters, D. Scandurra, S. Both, R. Steenbakkers, J.A. Langendijk Preselection Tool for the Model-Based Selection of Head and Neck Cancer Patients for Proton Therapy published pages: E384, ISSN: 0360-3016, DOI: 10.1016/j.ijrobp.2019.06.1647	International Journal of Radiation OncologyBiologyPhysics 105/1	2020-03-23
2019	M. Tambas, H.P. Van der Laan, J.G.M. Van den Hoek, H.P. Bijl, M. Dieters, R.G.J. Kierkels, D. Scandurra, S. Both, R.J.H.M. Steenbakkers, J.A. Langendijk OC-0563 First experience with the model-based selection of head and neck cancer patients for proton therapy published pages: S293-S294, ISSN: 0167-8140, DOI: 10.1016/s0167-8140(19)30983-1	Radiotherapy and Oncology 133	2020-03-23
2019	N. T. Henthorn, J. W. Warmenhoven, M. Sotiropoulos, A. H. Aitkenhead, E. A. K. Smith, S. P. Ingram, N. F. Kirkby, A.Â L. Chadwick, N. G. Burnet, R. I. Mackay, K. J. Kirkby, M. J. Merchant Clinically relevant nanodosimetric simulation of DNA damage complexity from photons and protons published pages: 6845-6858, ISSN: 2046-2069, DOI: 10.1039/c8ra10168j	RSC Advances 9/12	2020-03-23
2019	J. Schuemann, A. L. McNamara, J. W. Warmenhoven, N. T. Henthorn, K. J. Kirkby, M. J. Merchant, S. Ingram, H. Paganetti, K. D. Held, J. Ramos-Mendez, B. Faddegon, J. Perl, D. T. Goodhead, I. Plante, H. Rabus, H. Nettelbeck, W. Friedland, P. KundrÃ¡t, A. Ottolenghi, G. Baiocco, S. Barbieri, M. Dingfelder, S. Incerti, C. Villagrasa, M. Bueno, M. A. Bernal, S. Guatelli, D. Sakata, J. M. C. Brown, Z. F A New Standard DNA Damage (SDD) Data Format published pages: 76, ISSN: 0033-7587, DOI: 10.1667/rr15209.1	Radiation Research 191/1	2020-03-23
2018	Steffen Nielsen, Niels Bassler, Leszek Grzanka, Jan Swakon, Pawel Olko, Christian Nicolaj Andreassen, Jan Alsner, Brita Singers SÃ¸rensen Optimal reference genes for normalization of qPCR gene expression data from proton and photon irradiated dermal fibroblasts published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-30946-0	Scientific Reports 8/1	2020-03-23
2018	Anna MichaelidesovÃ¡ Cellular response to proton radiation. published pages: , ISSN: , DOI:		2020-03-23
2019	L. De Marzi, A. Da Fonseca, C. Moignier, A. Patriarca, F. Goudjil, A. Mazal, I. Buvat, J. HÃ©rault Experimental characterisation of a proton kernel model for pencil beam scanning techniques published pages: 195-203, ISSN: 1120-1797, DOI: 10.1016/j.ejmp.2019.07.013	Physica Medica 64	2020-03-23
2019	Walter Tinganelli, Timna Hitrec, Fabrizio Romani, Palma Simoniello, Fabio Squarcio, Agnese Stanzani, Emiliana Piscitiello, Valentina Marchesano, Marco Luppi, Maximiliano Sioli, Alexander Helm, Gaetano Compagnone, Alessio Morganti, Roberto Amici, Matteo Negrini, Antonio Zoccoli, Marco Durante, Matteo Cerri Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor published pages: 352, ISSN: 1422-0067, DOI: 10.3390/ijms20020352	International Journal of Molecular Sciences 20/2	2020-03-23
2019	Marco Durante, Silvia Formenti Harnessing radiation to improve immunotherapy: better with particles? published pages: 20190224, ISSN: 0007-1285, DOI: 10.1259/bjr.20190224	The British Journal of Radiology	2020-03-23
2019	Pierre Lansonneur, Vincent Favaudon, Sophie Heinrich, Charles Fouillade, Pierre Verrelle, Ludovic De Marzi Simulation and experimental validation of a prototype electron beam linear accelerator for preclinical studies published pages: 50-57, ISSN: 1120-1797, DOI: 10.1016/j.ejmp.2019.03.016	Physica Medica 60	2020-03-23

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The information about "INSPIRE" are provided by the European Opendata Portal: CORDIS opendata.