SaveHER
The inhibition of sorting proteins as a therapeutic avenue in HER2 positive breast cancer
Total Cost €
0EC-Contrib. €
0Partnership
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0SaveHER project word cloud
Explore the words cloud of the SaveHER project. It provides you a very rough idea of what is the project "SaveHER" about.
Project "SaveHER" data sheet
The following table provides information about the project.
| Coordinator |
TURUN YLIOPISTO
Organization address contact info |
| Coordinator Country | Finland [FI] |
| Total cost | 150˙000 € |
| EC max contribution | 150˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-03-01 to 2019-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | TURUN YLIOPISTO | FI (Turku) | coordinator | 150˙000.00 |
Map
Project objective
HER2 breast cancers are an aggressive type of breast cancer and have a poor prognosis. There are many therapies currently on the market to target this type of cancer, however they fail to deliver effective clinical results due to therapy resistance. In our ERC-CoG project, we found that proper endosomal trafficking is required for functional HER2 oncogenic signalling at the plasma membrane. Targeting HER2 endosomal traffic can result in effective treatment of HER2 cancers, without the risk of therapy resistance. As such, this innovation could deliver the first truly effective cancer treatment for HER2 breast cancer patients that do not respond to current treatments. In this ERC-PoC, we aim to prove that therapeutic targeting of endosomal traffic is effective in HER2 cancer models in vivo, as a monotherapy and synergistically with current therapeutic antibodies, and to explore the commercial avenues to exploit this finding.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Mika Pietilä, Pranshu Sahgal, Emilia Peuhu, Niklas Z. Jäntti, Ilkka Paatero, Elisa Närvä, Hussein Al-Akhrass, Johanna Lilja, Maria Georgiadou, Olav M. Andersen, Artur Padzik, Harri Sihto, Heikki Joensuu, Matias Blomqvist, Irena Saarinen, Peter J. Boström, Pekka Taimen, Johanna Ivaska SORLA regulates endosomal trafficking and oncogenic fitness of HER2 published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-10275-0 |
Nature Communications 10/1 | 2020-02-25 |
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