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CENTR-ALL SIGNED

Clarifying role of the CENTROSOME in abnormal mitotic processes featuring the most commonchildhood malignancy: paediatric High Hyperdiploid Acute Lymphoblastic Leukaemia (HHDpALL)

Total Cost €

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EC-Contrib. €

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Partnership

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 CENTR-ALL project word cloud

Explore the words cloud of the CENTR-ALL project. It provides you a very rough idea of what is the project "CENTR-ALL" about.

laboratory    genomics    kr    light    gain    world    amplification    mechanism    therapeutics    therapeutic    critical    chromosomal    sequential    inhibiting    variance    precise    first    potentials    centrosome    mer    germany    group    al    viability    malignancies    pattern    desirable    researcher    inter    functional    ultrastructural    original    hyperdiploidy    deaths    opposed    methodology    screening    solid    primary    mostly    illuminate    time    aflm    paediatric    showed    gains    headed    featured    abnormalities    fluorescence    frequent    children    commercial    cross    electron    et    prone    clustering    cell    metasystems    auml    poorly    technologies    biology    building    leader    avenue    correlative    align    accounts    automated    schwab    leukaemia    hhdpall    clarified    immunocytochemistry    institutes    er    personal    embl    throughput    cells    tumour    hcclem    diagnostic    microscopy    instability    visualized    pathomechanism    cin    evaluation    capacity    scanning    evolvement    error    indicate    centrosomes    hematologic    professor    academic    hhd    alwin    pall    cancer    accordingly    lymphoblastic    dkfz    acute    issue    join    ca    image    retain   

Project "CENTR-ALL" data sheet

The following table provides information about the project.

Coordinator
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG 

Organization address
address: IM NEUENHEIMER FELD 280
city: HEIDELBERG
postcode: 69120
website: www.dkfz.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-24   to  2021-01-23

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) coordinator 171˙460.00

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 Project objective

Paediatric Acute Lymphoblastic Leukaemia (pALL) still accounts for most cancer-related deaths in children. Although high hyperdiploidy (HHD) is the most frequent pattern, its pathomechanism remains poorly understood. Recently, Experienced Researcher (ER) et al showed that sequential chromosomal gains and chromosomal instability (CIN) are critical features in HHD-pALL evolvement. The most common cause of CIN is centrosome amplification (CA) and recent findings indicate that inhibiting centrosome clustering (mechanism by which tumour cells control CA to retain viability) is a promising therapeutic avenue. Opposed to most solid and hematologic malignancies, the role of CA in HHDpALL has not been clarified thus far. Primary goal of ER is to illuminate this issue, which is expected to result in new diagnostic- and screening methodologies, as well as novel therapeutics. ER will join a leading group in the field of ‘cancer associated centrosome abnormalities’ (headed by Professor Alwin Krämer), in one of Europe’s largest cancer research institutes (DKFZ, Germany), applying state-of the art technologies in genomics and functional cell biology. Centrosomes are mostly visualized by immunocytochemistry, but precise evaluation is error prone and featured with inter-personal/-laboratory variance. A diagnostic and high-throughput screening methodology thus is highly desirable. Accordingly, second aim is to develop a novel automated fluorescence light microscopy (aFLM) application for centrosome analysis, building on ER's previous experience, but in a cross-sector collaboration with a non-academic world leader in image analysis (MetaSystems, Germany). To gain ultrastructural information as well, ER will also align aFLM with scanning electron microscopy for the first time, in collaboration with the Schwab Group (EMBL, Germany) creating high-capacity correlative light electron microscopy (hcCLEM). Commercial potentials of above original developments will also be investigated.

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