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MagTendon SIGNED

Magnetically Assisted Tissue Engineering Technologies for Tendon Regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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MagTendon project word cloud

Explore the words cloud of the MagTendon project. It provides you a very rough idea of what is the project "MagTendon" about.

musculoskeletal dimensional tendons combined ground therapies external instructions superparamagnetic sophisticated stem base unveil explore remotely cellular criteria healing tenogenic substitutes critical stimuli breaking biomechanical closely signaling sorting easily programming nanoparticles vivo homeostasis relies 3d unravel laden bioengineering living stimulate magtendon multimaterial adipose vitro magnetic rational biofabrication cues mechanisms human recapitulate play developmental differentiation poor signalling trigger native tissue render cells repair nature motivated simultaneously structural te architecture obtaining hindered limitations innovative appropriate tendon tools limited cell magnetically behavioural conventional modulated mimicking patterns strategies models spmns responsive opposed prospect technological bioprinting mechanoreceptors morphogenesis disruptive composition regeneration engineering

Project "MagTendon" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDADE DO MINHO Organization address address: LARGO DO PACO city: BRAGA postcode: 4704 553 website: www.uminho.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	1˙999˙854 €
EC max contribution	1˙999˙854 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-COG
Funding Scheme	ERC-COG
Starting year	2018
Duration (year-month-day)	from 2018-05-01 to 2023-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDADE DO MINHO UNIVERSIDADE DO MINHO Organization address address: LARGO DO PACO city: BRAGA postcode: 4704 553 website: www.uminho.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (BRAGA)	coordinator	1˙999˙854.00

Map

Project objective

The poor healing ability of tendons, which play a critical role in the musculoskeletal system, as well as the limitations of currently used therapies have motivated tissue engineering (TE) strategies to develop living tendon substitutes. However, the limited knowledge on tendon development and healing processes has hindered the design of TE procedures that more closely recapitulate tendon morphogenesis. Extending beyond the state-of-the-art, MagTendon will explore conventional and innovative tools such as multimaterial 3 dimensional (3D) bioprinting to design magnetic responsive systems mimicking specific aspects of tendon tissue architecture, composition and biomechanical properties, which, combined with adequate stem cells, will render appropriate behavioural instructions to stimulate the regeneration of tendon tissue. Stem cell bioengineering approaches based on superparamagnetic nanoparticles (SPMNs), namely cell sorting, mechanoreceptors targeting and cell programming, will be used to unveil the cellular signalling pathways that trigger the tenogenic differentiation of the widely and easily obtained human adipose derived stem cells. Simultaneously, the 3D cell-laden magnetic system shall enable sophisticated 3D tissue models to unravel mechanisms behind tendon homeostasis and repair that will support the base knowledge to establish rational design criteria for the biofabrication of living tendon substitutes with the adequate signaling and structural cues to recapitulate tendon tissue developmental patterns. Therefore, the ground-breaking nature of the research proposed relies on the development of disruptive technological concepts for obtaining unique cell-laden 3D magnetically responsive systems that recapitulate key features of the native tissue and that can be further remotely modulated both in vitro and in vivo by the application of external magnetic stimuli, offering the prospect of tendon regeneration as opposed to simple tissue repair.

Publications

List of publications.
year	authors and title	journal	last update
2020	Isabel Calejo, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering published pages: 83-98, ISSN: 0167-7799, DOI: 10.1016/j.tibtech.2019.06.003	Trends in Biotechnology 38/1	2020-01-29
2019	Ana R. TomÃ¡s, Ana I. GonÃ§alves, Elvira Paz, Paulo Freitas, Rui M. A. Domingues, Manuela E. Gomes Magneto-mechanical actuation of magnetic responsive fibrous scaffolds boosts tenogenesis of human adipose stem cells published pages: 18255-18271, ISSN: 2040-3364, DOI: 10.1039/c9nr04355a	Nanoscale 11/39	2020-01-29
2019	Raquel Costa-Almeida, Isabel Calejo, Roberta Altieri, Rui M A Domingues, Emanuele Giordano, Rui L Reis, Manuela E Gomes Exploring platelet lysate hydrogel-coated suture threads as biofunctional composite living fibers for cell delivery in tissue repair published pages: 34104, ISSN: 1748-605X, DOI: 10.1088/1748-605x/ab0de6	Biomedical Materials 14/3	2020-01-29
2019	Isabel Calejo, Raquel Costaâ€Almeida, Rui L. Reis, Manuela E. Gomes A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendonâ€toâ€Bone Interface Gradient Scaffolds published pages: 1900200, ISSN: 2192-2640, DOI: 10.1002/adhm.201900200	Advanced Healthcare Materials 8/15	2020-01-29
2019	Raquel Costa-Almeida, Isabel Calejo, Manuela E. Gomes Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies published pages: 3002, ISSN: 1422-0067, DOI: 10.3390/ijms20123002	International Journal of Molecular Sciences 20/12	2020-01-29
2019	Isabel Calejo, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes Enthesis Tissue Engineering: Biological Requirements Meet at the Interface published pages: 330-356, ISSN: 1937-3368, DOI: 10.1089/ten.teb.2018.0383	Tissue Engineering Part B: Reviews 25/4	2020-01-29
2019	Ana I. GonÃ§alves, Dominika Berdecka, MÃ¡rcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes Evaluation of tenogenic differentiation potential of selected subpopulations of human adiposeâ€derived stem cells published pages: 2204-2217, ISSN: 1932-6254, DOI: 10.1002/term.2967	Journal of Tissue Engineering and Regenerative Medicine 13/12	2020-01-29
2020	BÃ¡rbara B Mendes, Manuel GÃ³mez-Florit, Alex G Hamilton, Michael S Detamore, Rui M A Domingues, Rui L Reis, Manuela E Gomes Human platelet lysate-based nanocomposite bioink for bioprinting hierarchical fibrillar structures published pages: 15012, ISSN: 1758-5090, DOI: 10.1088/1758-5090/ab33e8	Biofabrication 12/1	2020-01-29

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The information about "MAGTENDON" are provided by the European Opendata Portal: CORDIS opendata.

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