Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. magtendon

MagTendon SIGNED

Magnetically Assisted Tissue Engineering Technologies for Tendon Regeneration

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MagTendon project word cloud

Explore the words cloud of the MagTendon project. It provides you a very rough idea of what is the project "MagTendon" about.

composition    sophisticated    nature    tissue    breaking    developmental    behavioural    adipose    signaling    instructions    criteria    cellular    mechanisms    morphogenesis    multimaterial    limited    combined    strategies    easily    remotely    stimulate    engineering    technological    bioengineering    hindered    cell    human    tenogenic    nanoparticles    tools    disruptive    modulated    render    unveil    stem    patterns    native    recapitulate    3d    regeneration    ground    motivated    appropriate    living    musculoskeletal    conventional    tendons    stimuli    cells    opposed    simultaneously    innovative    relies    architecture    vitro    dimensional    vivo    rational    homeostasis    magnetically    substitutes    biofabrication    mimicking    te    responsive    external    obtaining    healing    unravel    explore    base    tendon    bioprinting    trigger    magnetic    closely    limitations    mechanoreceptors    structural    play    critical    programming    signalling    differentiation    cues    magtendon    spmns    repair    superparamagnetic    therapies    laden    poor    models    prospect    sorting    biomechanical   

Project "MagTendon" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSIDADE DO MINHO 

Organization address
address: LARGO DO PACO
city: BRAGA
postcode: 4704 553
website: www.uminho.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Portugal [PT]
 Total cost 1˙999˙854 €
 EC max contribution 1˙999˙854 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO MINHO PT (BRAGA) coordinator 1˙999˙854.00

Map

 Project objective

The poor healing ability of tendons, which play a critical role in the musculoskeletal system, as well as the limitations of currently used therapies have motivated tissue engineering (TE) strategies to develop living tendon substitutes. However, the limited knowledge on tendon development and healing processes has hindered the design of TE procedures that more closely recapitulate tendon morphogenesis. Extending beyond the state-of-the-art, MagTendon will explore conventional and innovative tools such as multimaterial 3 dimensional (3D) bioprinting to design magnetic responsive systems mimicking specific aspects of tendon tissue architecture, composition and biomechanical properties, which, combined with adequate stem cells, will render appropriate behavioural instructions to stimulate the regeneration of tendon tissue. Stem cell bioengineering approaches based on superparamagnetic nanoparticles (SPMNs), namely cell sorting, mechanoreceptors targeting and cell programming, will be used to unveil the cellular signalling pathways that trigger the tenogenic differentiation of the widely and easily obtained human adipose derived stem cells. Simultaneously, the 3D cell-laden magnetic system shall enable sophisticated 3D tissue models to unravel mechanisms behind tendon homeostasis and repair that will support the base knowledge to establish rational design criteria for the biofabrication of living tendon substitutes with the adequate signaling and structural cues to recapitulate tendon tissue developmental patterns. Therefore, the ground-breaking nature of the research proposed relies on the development of disruptive technological concepts for obtaining unique cell-laden 3D magnetically responsive systems that recapitulate key features of the native tissue and that can be further remotely modulated both in vitro and in vivo by the application of external magnetic stimuli, offering the prospect of tendon regeneration as opposed to simple tissue repair.

 Publications

year authors and title journal last update
List of publications.
2020 Isabel Calejo, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes
A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering
published pages: 83-98, ISSN: 0167-7799, DOI: 10.1016/j.tibtech.2019.06.003 		Trends in Biotechnology 38/1 2020-01-29
2019 Ana R. Tomás, Ana I. Gonçalves, Elvira Paz, Paulo Freitas, Rui M. A. Domingues, Manuela E. Gomes
Magneto-mechanical actuation of magnetic responsive fibrous scaffolds boosts tenogenesis of human adipose stem cells
published pages: 18255-18271, ISSN: 2040-3364, DOI: 10.1039/c9nr04355a 		Nanoscale 11/39 2020-01-29
2019 Raquel Costa-Almeida, Isabel Calejo, Roberta Altieri, Rui M A Domingues, Emanuele Giordano, Rui L Reis, Manuela E Gomes
Exploring platelet lysate hydrogel-coated suture threads as biofunctional composite living fibers for cell delivery in tissue repair
published pages: 34104, ISSN: 1748-605X, DOI: 10.1088/1748-605x/ab0de6 		Biomedical Materials 14/3 2020-01-29
2019 Isabel Calejo, Raquel Costa‐Almeida, Rui L. Reis, Manuela E. Gomes
A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendon‐to‐Bone Interface Gradient Scaffolds
published pages: 1900200, ISSN: 2192-2640, DOI: 10.1002/adhm.201900200 		Advanced Healthcare Materials 8/15 2020-01-29
2019 Raquel Costa-Almeida, Isabel Calejo, Manuela E. Gomes
Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies
published pages: 3002, ISSN: 1422-0067, DOI: 10.3390/ijms20123002 		International Journal of Molecular Sciences 20/12 2020-01-29
2019 Isabel Calejo, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes
Enthesis Tissue Engineering: Biological Requirements Meet at the Interface
published pages: 330-356, ISSN: 1937-3368, DOI: 10.1089/ten.teb.2018.0383 		Tissue Engineering Part B: Reviews 25/4 2020-01-29
2019 Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes
Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose‐derived stem cells
published pages: 2204-2217, ISSN: 1932-6254, DOI: 10.1002/term.2967 		Journal of Tissue Engineering and Regenerative Medicine 13/12 2020-01-29
2020 Bárbara B Mendes, Manuel Gómez-Florit, Alex G Hamilton, Michael S Detamore, Rui M A Domingues, Rui L Reis, Manuela E Gomes
Human platelet lysate-based nanocomposite bioink for bioprinting hierarchical fibrillar structures
published pages: 15012, ISSN: 1758-5090, DOI: 10.1088/1758-5090/ab33e8 		Biofabrication 12/1 2020-01-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MAGTENDON" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MAGTENDON" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

FatVirtualBiopsy (2020)

MRI toolkit for in vivo fat virtual biopsy

Read More  

TransTempoFold (2019)

A need for speed: mechanisms to coordinate protein synthesis and folding in metazoans

Read More  

TechChild (2019)

Just because we can, should we? An anthropological perspective on the initiation of technology dependence to sustain a child’s life

Read More