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4DBIOSERS SIGNED

Four-Dimensional Monitoring of Tumour Growth by Surface Enhanced Raman Scattering

Total Cost €

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EC-Contrib. €

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Partnership

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 4DBIOSERS project word cloud

Explore the words cloud of the 4DBIOSERS project. It provides you a very rough idea of what is the project "4DBIOSERS" about.

detection    encoded    tissue    scaffolds    drugs    enhanced    simulate    multidisciplinary    combine    surface    animal    printing    stable    accessible    monitor    building    release    readily    indicators    breast    drawbacks    variety    cellular    light    models    stability    excited    cells    tomography    adding    co    tumour    diseases    offers    tags    periods    fate    limited    visible    tumours    dyes    metabolites    optical    scope    cultures    4dbiosers    overcome    fluorescent    standard    acquiring    near    ultra    environment    hybrid    time    avoiding    multiplexed    nanoparticle    healthy    cell    3d    window    tissues    bright    fourth    transparency    penetration    experimentation    confocal    microscopy    melanoma    simultaneous    biomarkers    ir    bioanalytes    2d    cancer    bioimaging    intensity    monitoring    sers    incubated    nanocomposites    possibility    culture    dimensional    realistic    biological    correlated    raman    scattering    labelled    monitored    dimension    optimization    extended    dynamics    signals    recording    generate   

Project "4DBIOSERS" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙410˙771 €
 EC max contribution 2˙410˙771 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 2˙410˙771.00

Map

 Project objective

Optical bioimaging is limited by visible light penetration depth and stability of fluorescent dyes over extended periods of time. Surface enhanced Raman scattering (SERS) offers the possibility to overcome these drawbacks, through SERS-encoded nanoparticle tags, which can be excited with near-IR light (within the biological transparency window), providing high intensity, stable, multiplexed signals. SERS can also be used to monitor relevant bioanalytes within cells and tissues, during the development of diseases, such as tumours. In 4DBIOSERS we shall combine both capabilities of SERS, to go well beyond the current state of the art, by building three-dimensional scaffolds that support tissue (tumour) growth within a controlled environment, so that not only the fate of each (SERS-labelled) cell within the tumour can be monitored in real time (thus adding a fourth dimension to SERS bioimaging), but also recording the release of tumour metabolites and other indicators of cellular activity. Although 4DBIOSERS can be applied to a variety of diseases, we shall focus on cancer, melanoma and breast cancer in particular, as these are readily accessible by optical methods. We aim at acquiring a better understanding of tumour growth and dynamics, while avoiding animal experimentation. 3D printing will be used to generate hybrid scaffolds where tumour and healthy cells will be co-incubated to simulate a more realistic environment, thus going well beyond the potential of 2D cell cultures. Each cell type will be encoded with ultra-bright SERS tags, so that real-time monitoring can be achieved by confocal SERS microscopy. Tumour development will be correlated with simultaneous detection of various cancer biomarkers, during standard conditions and upon addition of selected drugs. The scope of 4DBIOSERS is multidisciplinary, as it involves the design of high-end nanocomposites, development of 3D cell culture models and optimization of emerging SERS tomography methods.

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The information about "4DBIOSERS" are provided by the European Opendata Portal: CORDIS opendata.

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