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MIMetiCO SIGNED

Multiscale Integrative Approach for Corneal Biomechanics to Assess Corneal Crosslinking

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MIMetiCO project word cloud

Explore the words cloud of the MIMetiCO project. It provides you a very rough idea of what is the project "MIMetiCO" about.

modeling    worldwide    collagen    tests    amount    confocal    corneal    mimetico    pressure    protrusion    biochemical    fibrils    refractive    people    treatments    visually    microscopy    computational    rely    tissue    250    mechanical    plan    uniformly    breaking    unexpected    ophthalmology    scales    economic    noninvasive    ectasias    experiments    orientation    pathologies    crosslinks    approximately    intraocular    treatment    impaired    biomechanics    combine    model    technologies    chemical    halting    interventions    molecules    clinical    inflation    becomes    framework    stresses    cxl    stiffening    generation    depending    usually    first    ground    calibrate    surgery    mechanisms    stiffness    density    micro    nano    vision    mainly    crosslinking    cornea    benefit    virtual    imbalanced    completely    characterization    silico    multiscale    models    outcomes    simulate    strategies    bounding    phenomena    social    postsurgical    million    inducing    keratoconus    balance    structural    morphological    internal    intermolecular    macroscopic   

Project "MIMetiCO" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 175˙419.00

Map

 Project objective

Approximately 250 million people worldwide are visually impaired, and this has great economic and social impact. One of the pathologies of vision loss is keratoconus, in which the mechanical balance of the cornea depending on intraocular pressure and internal stresses in corneal tissue becomes imbalanced, which can result in a corneal protrusion.

Corneal crosslinking (CXL) is a clinical treatment that increases the overall mechanical stiffness of the cornea by inducing chemical bounding between collagen molecules. CXL is the present of halting corneal ectasias, and the future of noninvasive refractive surgery. However, its micro/nano-mechanisms are not completely understood. Moreover, CXL is usually applied uniformly in corneal treatments, which can result in over-stiffening and unexpected postsurgical outcomes.

Ophthalmology can benefit from in silico modeling to plan and improve such interventions. However, current computational models are mainly macroscopic and cannot simulate complex phenomena involved in CXL. Multiscale computational models could improve clinical strategies by including information at different scales.

MIMetiCO’s goal is to combine experiments and modelling at different scales to provide a multiscale characterization of corneal biomechanics before and after CXL. This characterization will rely on both ground-breaking and well-established technologies that include confocal microscopy, biochemical assessment, and mechanical inflation tests to determine morphological (orientation and density of fibrils), biochemical (amount of intermolecular crosslinks), and mechanical features of the cornea.

MIMetiCO will use this information to calibrate the first in silico model of the cornea using a multiscale structural approach to build a virtual framework to simulate potential CXL treatments.

MIMetiCO is the next step in ophthalmology, which has the potential to bring into being a new generation of clinical assessment.

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The information about "MIMETICO" are provided by the European Opendata Portal: CORDIS opendata.

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