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MIMetiCO SIGNED

Multiscale Integrative Approach for Corneal Biomechanics to Assess Corneal Crosslinking

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MIMetiCO project word cloud

Explore the words cloud of the MIMetiCO project. It provides you a very rough idea of what is the project "MIMetiCO" about.

mechanisms    ground    uniformly    amount    visually    collagen    first    corneal    density    crosslinks    refractive    worldwide    computational    confocal    fibrils    modeling    phenomena    becomes    noninvasive    million    multiscale    outcomes    stresses    protrusion    simulate    model    intraocular    experiments    intermolecular    postsurgical    unexpected    mainly    scales    depending    bounding    pathologies    interventions    structural    keratoconus    chemical    250    internal    breaking    pressure    halting    strategies    tests    benefit    biochemical    usually    technologies    stiffening    economic    cornea    mechanical    micro    generation    inducing    impaired    calibrate    treatments    framework    vision    stiffness    macroscopic    microscopy    biomechanics    silico    inflation    orientation    cxl    ectasias    characterization    approximately    clinical    rely    people    nano    combine    social    plan    crosslinking    surgery    tissue    molecules    virtual    ophthalmology    balance    completely    imbalanced    models    mimetico    treatment    morphological   

Project "MIMetiCO" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 175˙419.00

Map

 Project objective

Approximately 250 million people worldwide are visually impaired, and this has great economic and social impact. One of the pathologies of vision loss is keratoconus, in which the mechanical balance of the cornea depending on intraocular pressure and internal stresses in corneal tissue becomes imbalanced, which can result in a corneal protrusion.

Corneal crosslinking (CXL) is a clinical treatment that increases the overall mechanical stiffness of the cornea by inducing chemical bounding between collagen molecules. CXL is the present of halting corneal ectasias, and the future of noninvasive refractive surgery. However, its micro/nano-mechanisms are not completely understood. Moreover, CXL is usually applied uniformly in corneal treatments, which can result in over-stiffening and unexpected postsurgical outcomes.

Ophthalmology can benefit from in silico modeling to plan and improve such interventions. However, current computational models are mainly macroscopic and cannot simulate complex phenomena involved in CXL. Multiscale computational models could improve clinical strategies by including information at different scales.

MIMetiCO’s goal is to combine experiments and modelling at different scales to provide a multiscale characterization of corneal biomechanics before and after CXL. This characterization will rely on both ground-breaking and well-established technologies that include confocal microscopy, biochemical assessment, and mechanical inflation tests to determine morphological (orientation and density of fibrils), biochemical (amount of intermolecular crosslinks), and mechanical features of the cornea.

MIMetiCO will use this information to calibrate the first in silico model of the cornea using a multiscale structural approach to build a virtual framework to simulate potential CXL treatments.

MIMetiCO is the next step in ophthalmology, which has the potential to bring into being a new generation of clinical assessment.

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The information about "MIMETICO" are provided by the European Opendata Portal: CORDIS opendata.

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