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MIMetiCO SIGNED

Multiscale Integrative Approach for Corneal Biomechanics to Assess Corneal Crosslinking

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MIMetiCO project word cloud

Explore the words cloud of the MIMetiCO project. It provides you a very rough idea of what is the project "MIMetiCO" about.

technologies    visually    keratoconus    unexpected    tissue    noninvasive    crosslinks    generation    chemical    becomes    confocal    completely    fibrils    internal    modeling    first    ectasias    orientation    macroscopic    social    density    collagen    phenomena    structural    scales    treatment    amount    micro    imbalanced    crosslinking    250    bounding    stiffening    usually    clinical    characterization    worldwide    interventions    plan    tests    nano    postsurgical    combine    breaking    ground    computational    refractive    experiments    mechanisms    mechanical    balance    pathologies    mimetico    ophthalmology    biomechanics    mainly    molecules    cornea    vision    halting    impaired    people    cxl    multiscale    protrusion    framework    stiffness    depending    morphological    treatments    models    economic    uniformly    strategies    rely    surgery    outcomes    inducing    approximately    biochemical    benefit    model    inflation    microscopy    simulate    pressure    intraocular    intermolecular    corneal    stresses    calibrate    silico    virtual    million   

Project "MIMetiCO" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 175˙419.00

Map

 Project objective

Approximately 250 million people worldwide are visually impaired, and this has great economic and social impact. One of the pathologies of vision loss is keratoconus, in which the mechanical balance of the cornea depending on intraocular pressure and internal stresses in corneal tissue becomes imbalanced, which can result in a corneal protrusion.

Corneal crosslinking (CXL) is a clinical treatment that increases the overall mechanical stiffness of the cornea by inducing chemical bounding between collagen molecules. CXL is the present of halting corneal ectasias, and the future of noninvasive refractive surgery. However, its micro/nano-mechanisms are not completely understood. Moreover, CXL is usually applied uniformly in corneal treatments, which can result in over-stiffening and unexpected postsurgical outcomes.

Ophthalmology can benefit from in silico modeling to plan and improve such interventions. However, current computational models are mainly macroscopic and cannot simulate complex phenomena involved in CXL. Multiscale computational models could improve clinical strategies by including information at different scales.

MIMetiCO’s goal is to combine experiments and modelling at different scales to provide a multiscale characterization of corneal biomechanics before and after CXL. This characterization will rely on both ground-breaking and well-established technologies that include confocal microscopy, biochemical assessment, and mechanical inflation tests to determine morphological (orientation and density of fibrils), biochemical (amount of intermolecular crosslinks), and mechanical features of the cornea.

MIMetiCO will use this information to calibrate the first in silico model of the cornea using a multiscale structural approach to build a virtual framework to simulate potential CXL treatments.

MIMetiCO is the next step in ophthalmology, which has the potential to bring into being a new generation of clinical assessment.

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The information about "MIMETICO" are provided by the European Opendata Portal: CORDIS opendata.

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