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MIMetiCO SIGNED

Multiscale Integrative Approach for Corneal Biomechanics to Assess Corneal Crosslinking

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MIMetiCO project word cloud

Explore the words cloud of the MIMetiCO project. It provides you a very rough idea of what is the project "MIMetiCO" about.

density    simulate    macroscopic    social    vision    benefit    outcomes    framework    micro    computational    approximately    stresses    confocal    ground    visually    stiffness    pressure    postsurgical    worldwide    intraocular    internal    microscopy    crosslinking    ectasias    noninvasive    biomechanics    cxl    clinical    becomes    surgery    chemical    characterization    technologies    balance    stiffening    interventions    scales    inducing    experiments    corneal    depending    mainly    imbalanced    tests    models    modeling    amount    cornea    economic    phenomena    rely    multiscale    fibrils    generation    silico    strategies    pathologies    plan    mechanisms    250    morphological    completely    combine    calibrate    people    refractive    mechanical    inflation    model    million    biochemical    intermolecular    crosslinks    treatments    bounding    first    keratoconus    virtual    molecules    impaired    unexpected    nano    mimetico    tissue    collagen    treatment    uniformly    structural    ophthalmology    breaking    halting    usually    orientation    protrusion   

Project "MIMetiCO" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 175˙419.00

Map

 Project objective

Approximately 250 million people worldwide are visually impaired, and this has great economic and social impact. One of the pathologies of vision loss is keratoconus, in which the mechanical balance of the cornea depending on intraocular pressure and internal stresses in corneal tissue becomes imbalanced, which can result in a corneal protrusion.

Corneal crosslinking (CXL) is a clinical treatment that increases the overall mechanical stiffness of the cornea by inducing chemical bounding between collagen molecules. CXL is the present of halting corneal ectasias, and the future of noninvasive refractive surgery. However, its micro/nano-mechanisms are not completely understood. Moreover, CXL is usually applied uniformly in corneal treatments, which can result in over-stiffening and unexpected postsurgical outcomes.

Ophthalmology can benefit from in silico modeling to plan and improve such interventions. However, current computational models are mainly macroscopic and cannot simulate complex phenomena involved in CXL. Multiscale computational models could improve clinical strategies by including information at different scales.

MIMetiCO’s goal is to combine experiments and modelling at different scales to provide a multiscale characterization of corneal biomechanics before and after CXL. This characterization will rely on both ground-breaking and well-established technologies that include confocal microscopy, biochemical assessment, and mechanical inflation tests to determine morphological (orientation and density of fibrils), biochemical (amount of intermolecular crosslinks), and mechanical features of the cornea.

MIMetiCO will use this information to calibrate the first in silico model of the cornea using a multiscale structural approach to build a virtual framework to simulate potential CXL treatments.

MIMetiCO is the next step in ophthalmology, which has the potential to bring into being a new generation of clinical assessment.

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The information about "MIMETICO" are provided by the European Opendata Portal: CORDIS opendata.

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