EpiSTOX SIGNED

Project "EpiSTOX" data sheet

The following table provides information about the project.

 Partnership

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 Project objective

'The study of emergent pollutants is included in the priority research guidelines of many environmental- and health-regulation bodies, such as the World Health Organisation, the USA Environmental Protection Agency or the EFSA and ECHA agencies of the European Commission. In this regard this regulatory bodies have identified substances of very high concern, including Endocrine Disruptors (EDCs). An emerging concern is related to substances that are able to modify cellular regulatory mechanisms long after the actual exposure occurred, a long-term effect mediated by chemical chromatin changes and integrated into the concept of epigenetics. The prevalent hypothesis is to use the 'epigenetic foot-print” as a tool to evaluate the exposure of a given organism to toxicants, with the ultimate goal of identify determine if epigenetic signatures characterized after early development exposures are maintained through time once the pollutant exposure ceased, and if those can cause adverse effects on the exposed animals. In that context the main goal of the present proposal is to identify epigenetic footprints characteristic of early development exposures to EDCs in zebrafish. This project intends to: 1) To identify common epigenetic markers regulated by EDC exposures during early development; 2) To integrate transcriptomic and epigenetic platforms to identify relevant biological pathways characteristic of EDCs exposures. Results from this study would be very useful to identify target epigenetic biomarkers and develop cost-effective high-throughput methodologies to screen for epigenetic signatures after EDCs exposures.'