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ROSETTA SIGNED

Deciphering the Role of aberrant glycOSylation in the rEsponse to Targeted TherApies for breast cancer

Total Cost €

EC-Contrib. €

Partnership

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ROSETTA project word cloud

Explore the words cloud of the ROSETTA project. It provides you a very rough idea of what is the project "ROSETTA" about.

her2 realm imaging antibody undermine pathological heterotypic angiogenesis multiple biology receptor unexplored layer treatment driving cells resistance linked improvement binding largely cancers driver cell options markers plan scenario efficacy combining revolutionized tumor therapeutic glycosylation proteins holds progression therapies mediated interconnected clinical drive modulation accomplished heavily invasion biopsies patients cancer cultures successful resistant tumorigenesis aberrant data 3d line genes complexity lines incomplete deciphering signaling hallmark spheroids dissect breast glycosylated treatments crosstalk obstacle trastuzumab immune

Project "ROSETTA" data sheet

The following table provides information about the project.

Coordinator	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	175˙572 €
EC max contribution	175˙572 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2019
Funding Scheme	MSCA-IF-EF-RI
Starting year	2020
Duration (year-month-day)	from 2020-04-01 to 2022-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	coordinator	175˙572.00

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Project objective

Resistance and cancer progression remain a major obstacle to the successful treatment of cancer. In HER2 breast cancer, the development of targeted therapies such as trastuzumab, has revolutionized the treatment for these cancer patients. However, a significant number of patients develop resistance. In this realm, my previous work focused on understanding the crosstalk of interconnected signaling pathways in HER2 cancer cells that drive tumorigenesis and undermine the efficacy of current treatments. The research goal of this proposal is to provide a new focus to the challenge of resistance by deciphering the role of glycosylation in driving resistance to HER2-targeted therapies. Aberrant glycosylation of proteins is a hallmark in cancer and has been linked to multiple processes such as invasion, angiogenesis and modulation of the immune response. The receptor HER2, the main driver of HER2 cancers, is heavily glycosylated and is the target of current antibody-based treatments, including trastuzumab. In this scenario, this proposal aims to (1) identify glycosylation-related genes associated with incomplete pathological response to trastuzumab to (2) dissect their role on trastuzumab binding and (3) assess their impact in the response to trastuzumab mediated by immune cells. This research plan will be accomplished combining the analysis of clinical data from tumor biopsies, the use of trastuzumab-resistant tumor-derived breast cancer cell lines and, the implementation and imaging of 3D heterotypic cultures of cancer cell line-derived spheroids and immune cells. Thus, this proposal addresses a largely unexplored layer of complexity in cancer biology – the role of glycosylation in resistance to targeted therapies – and holds the potential to identify new markers of response to therapies and open the path to new therapeutic options for the improvement of current treatments.

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The information about "ROSETTA" are provided by the European Opendata Portal: CORDIS opendata.