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SLAMseq SIGNED

SLAMseq: Temporal resolution in gene expression profiling across multiple platforms

Total Cost €

EC-Contrib. €

Partnership

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SLAMseq project word cloud

Explore the words cloud of the SLAMseq project. It provides you a very rough idea of what is the project "SLAMseq" about.

labeling fails resolve modify malignancies molecular gene principles turnover validate biogenesis slamseq thereof manner current experimental erc metabolic modified treatments parallel molecules intracellular sequencing chemically protocols revolutionise insights abundance rapid mirlife scalable rna applicability data preliminary profiling stg biomedical analogs commercialize unprecedented expression poc genome reflected prove relative underlying seq human provides regulation kinetics basis uncovers coupled time resolved analog transcriptomics massive nucleoside

Project "SLAMseq" data sheet

The following table provides information about the project.

Coordinator	INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH Organization address address: DR BOHRGASSE 3 city: WIEN postcode: 1030 website: www.imba.oeaw.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-PoC
Funding Scheme	ERC-POC
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2020-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH Organization address address: DR BOHRGASSE 3 city: WIEN postcode: 1030 website: www.imba.oeaw.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	coordinator	150˙000.00

Map

Project objective

Current gene expression profiling by massive parallel RNA sequencing provides insight into relative abundance of RNA molecules but fails to resolve the underlying principles in gene regulation that are reflected in the intracellular kinetics of RNA biogenesis, processing and turnover. In the ERC-StG 'miRLIFE', we have developed a novel technology – SLAMseq – that uncovers a chemically modified nucleoside analog by sequencing. When coupled to metabolic RNA labeling and targeted RNA sequencing, SLAMseq provides unprecedented insights into the intracellular kinetics of gene expression in a rapid, scalable and cost-effective manner. Preliminary data show that the SLAMseq technology can be used to modify other nucleoside analogs and be applied for non-targeted RNA seq protocols. In this PoC, we aim to validate and prove this broader applicability of SLAMseq in order to enable and commercialize genome-wide, time-resolved transcriptomics. In this way, metabolic RNA sequencing will revolutionise biomedical research by providing experimental access to the molecular basis of human malignancies and treatments thereof.

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The information about "SLAMSEQ" are provided by the European Opendata Portal: CORDIS opendata.