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ATHENA SIGNED

Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies

Total Cost €

EC-Contrib. €

Partnership

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ATHENA project word cloud

Explore the words cloud of the ATHENA project. It provides you a very rough idea of what is the project "ATHENA" about.

membrane world ex mobilise harm thyroid foetal capturing barrier strategy guidelines close collectively endocrine barriers athena transporters disruptor adulthood vivo progress endocrinologists adverse function experts critical incorporation oecd stream networks deficiency deiodinases capture cerebrospinal chemicals disruption neurodevelopmental strategies placenta interfere protect foetus natal blood left disrupting screening local post construction made of international dehalogenases gaps axis conceive hormone endpoints aop identification hormones fluid life supply physiological adult scientific hazard harmonisation qsars brain inhibition libraries compound maternal cell

Project "ATHENA" data sheet

The following table provides information about the project.

Coordinator	BRUNEL UNIVERSITY LONDON Organization address address: KINGSTON LANE city: UXBRIDGE postcode: UB8 3PH website: www.brunel.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	6˙565˙463 €
EC max contribution	6˙565˙463 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2018-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	BRUNEL UNIVERSITY LONDON BRUNEL UNIVERSITY LONDON Organization address address: KINGSTON LANE city: UXBRIDGE postcode: UB8 3PH website: www.brunel.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (UXBRIDGE)	coordinator	1˙052˙313.00
2	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	participant	1˙071˙857.00
3	CHARITE - UNIVERSITAETSMEDIZIN BERLIN CHARITE - UNIVERSITAETSMEDIZIN BERLIN Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 website: www.charite.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	997˙330.00
4	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	778˙372.00
5	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	698˙130.00
6	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	652˙917.00
7	WATCHFROG WATCHFROG Organization address address: 4 RUE PIERRE FONTAINE city: EVRY postcode: 91000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (EVRY)	participant	576˙505.00
8	RISE RESEARCH INSTITUTES OF SWEDEN AB RISE RESEARCH INSTITUTES OF SWEDEN AB Organization address address: BRINELLGATAN 4 city: BORAS postcode: 501 15 website: www.ri.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (BORAS)	participant	530˙245.00
9	OREBRO UNIVERSITY OREBRO UNIVERSITY Organization address address: FAKULTETSGATAN 1 city: OREBRO postcode: 70182 website: www.oru.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (OREBRO)	participant	157˙255.00
10	KARLSTADS UNIVERSITET KARLSTADS UNIVERSITET Organization address address: UNIVERSITETSGATAN 2 city: KARLSTAD postcode: 651 88 website: www.kau.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (KARLSTAD)	participant	50˙537.00

Map

Project objective

The ATHENA consortium aims to mobilise the scientific progress made in recent years to close critical gaps left open in test methods for thyroid hormone axis disrupting-chemicals. We will develop new methods for incorporation into existing OECD test guidelines that can capture the consequences of maternal thyroid hormone deficiency on the developing brain, due to disruption of delivery of thyroid hormones to the foetus. To make this possible, we will establish new endpoints for identifying down-stream effects on the developing brain in foetal and post-natal life. We will provide new test methods for chemicals that interfere with the delivery of thyroid hormones to the foetus and the adult brain across physiological barriers such as the placenta, the blood brain barrier and the blood brain cerebrospinal fluid barrier. We will also develop QSARs for the screening of large compound libraries and methods for capturing disruption of the local supply of thyroid hormone by inhibition of deiodinases, dehalogenases and cell membrane transporters. Based on the construction of AOP networks for adverse neurodevelopmental effects, we will deliver a comprehensive testing strategy that can protect from chemicals that have the potential to harm brain development in foetal life and adulthood by disrupting the availability of thyroid hormones. Finally, ATHENA will conceive strategies for the international harmonisation of screening, testing and hazard identification for thyroid hormone axis disrupting chemicals. ATHENA comprises world-leading endocrinologists, experts in endocrine disruption and experts in modelling brain function ex vivo who collectively will deliver a step change in thyroid disruptor testing.

Deliverables

List of deliverables.
Project website	Websites, patent fillings, videos etc.	2020-04-21 01:01:02

Take a look to the deliverables list in detail: detailed list of ATHENA deliverables.

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The information about "ATHENA" are provided by the European Opendata Portal: CORDIS opendata.