Opendata, web and dolomites

EngineeringBAP SIGNED

Engineering brain activity patterns for therapeutics of neuropsychiatric and neurological disorders

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EngineeringBAP project word cloud

Explore the words cloud of the EngineeringBAP project. It provides you a very rough idea of what is the project "EngineeringBAP" about.

intractable    rodents    ecog    circuit    behaviours    precision    first    achievable    constitutes    noninvasively    data    minimally    phenotypes    underlying    resolution    primates    mouse    lack    manipulating    modulating    disorders    plan    human    circuits    superficial    zebrafish    functional    mutant    single    networks    abnormal    localized    neuromorphic    simultaneously    neuromodulators    mu    scalability    neuromodulator    precise    battery    sub    direct    cocktails    preliminary    pathological    power    pulses    treatment    engineered    neuronal    patterns    receptive    reading    employ    proof    compulsivity    limited    reverse    neuron    multiple    invasive    signals    layers    symptoms    microparticles    dysfunctions    minimallyinvasive    neuropsychiatric    comprehensively    ultrasound    vivo    detect    model    designed    anxiety    behavioural    flexible    modifications    opening    neurological    correct    connectivity    drug    cortical    blood    brain    damaging    technologies    barrier    humans    obsessive    measuring   

Project "EngineeringBAP" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙998˙984 €
 EC max contribution 1˙998˙984 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 1˙998˙984.00

Map

 Project objective

Neuropsychiatric and neurological disorders are complex dysfunctions of neuronal circuits. Their treatment has been limited by the lack of non-invasive methods for measuring the underlying circuit dysfunctions, and for direct and localized modifications of these circuits. We propose minimally invasive technologies for measuring brain activity and functional connectivity patterns, and for manipulating them directly in vivo to correct the abnormal behavioural phenotypes (in rodents with potential scalability to non-human primates and humans). First, we present a proof-of-principle study on mutant zebrafish, in which we correct whole-brain level abnormal activity patterns and behaviours by using large-scale single-neuron resolution measurements, and by simultaneously modulating multiple sub-networks via neuromodulator cocktails. Next, we present strong preliminary data in rodents and our plan: (1) For manipulating brain circuits in rodents/primates noninvasively, we will develop technologies that can deliver receptive-specific neuromodulators to spatially precise brain targets without opening/damaging the blood brain barrier. These methods will employ engineered ultrasound pulses and drug carrying microparticles we designed. (2) For reading out the brain circuits in rodents/primates, we will develop flexible low-power neuromorphic μECoG circuits that can detect single neuron signals from superficial cortical layers of many cortical areas simultaneously. (3) Finally, these novel technologies will be comprehensively evaluated on a mouse model of obsessive compulsivity and anxiety using a battery of behavioural tasks to reverse the pathological symptoms (beyond what is achievable by existing approaches). This project constitutes a major step towards the development and testing of minimallyinvasive and high-precision technologies for manipulating brain activity patterns, which can impact both our understanding of the brain and treatment of intractable brain disorders.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ENGINEERINGBAP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ENGINEERINGBAP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ENUF (2019)

Evaluation of Novel Ultra-Fast selective III-V Epitaxy

Read More  

REAL (2019)

Rights and Egalitarianism

Read More  

HydroLieve (2018)

A long-lasting non-migrating hydrogel for relieving chronic pain

Read More