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distalC-Hfun SIGNED

Transient directing group for catalytic distal C–H functionalisation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 distalC-Hfun project word cloud

Explore the words cloud of the distalC-Hfun project. It provides you a very rough idea of what is the project "distalC-Hfun" about.

functionalisation    tools    catalyzed    amongst    consequence    covalent    substitutions    organic    protocol    despite    extremely    molecules    conventional    decades    distal    dgs    transition    additional    removes    economical    para    made    catalytic    activation    boundaries    mainly    distinguishing    functional    amount    direct    variety    catalysis    reversibly    ubiquitous    carbonyl    context    applicability    relatively    date    differences    routes    progress    strategies    synthetic    lowering    arenes    area    groups    prepare    seek    synthesis    realization    normally    subtle    reactivity    group    functionalised    atom    difficult    removal    ortho    day    binds    remote    emerged    substrate    scarce    directing    molecule    inert    add    outlined    modifications    dg    push    transient    imine    precisely    unreactive    tm    compounds    treating    efficiency    activate    metal    methodology    bonds    sequence    enabled    site    active    final    installation    last    meticulous    motifs    biologically    meta    stoichiometric    bond   

Project "distalC-Hfun" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-08   to  2022-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 224˙933.00

Map

 Project objective

The development of methods for the transition metal (TM) catalyzed functionalisation of C–H bonds has emerged as an extremely important topic in present-day organic synthesis aiming at providing tools that allow treating the ubiquitous and normally inert C–H bonds as any other functional group for synthetic modifications. However, controlling the site of C–H activation or distinguishing between the subtle differences in reactivity of two given C–H bonds is one of the major challenges yet to be addressed. In this context, meticulous design of directing groups (DG) over the last decades has enabled a variety of relatively unreactive C–H bonds to be functionalised under transition metal catalysis. To date, much progress has been made in developing strategies for the ortho-functionalisation of arenes mainly through the installation of DGs in the stoichiometric amount. However, these DGs are not part of the final target molecule; as a consequence, its covalent installation and/or removal from the substrate will add additional steps to the synthetic sequence thus lowering the efficiency and applicability of these approaches. On the other hand, distal meta- and para-C–H functionalisation approaches, are extremely scarce despite these substitutions are widespread motifs amongst biologically active molecules. The research outlined in this proposal aims at developing a process that makes use of a transient DG in a catalytic amount which binds reversibly with carbonyl compounds via imine formation leading to a novel direct meta- and para-functionalisation methodology. Precisely, we seek to develop a protocol that removes the need for the use of stoichiometric directing groups to activate distal C–H bonds. The realization of the proposed objectives will push the boundaries of the state-of-the-art in the area of remote C–H bond functionalisation by providing atom and step economical access to molecules that are difficult to prepare via conventional multi-step routes.

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The information about "DISTALC-HFUN" are provided by the European Opendata Portal: CORDIS opendata.

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