DISCONNECTOME SIGNED
Brain connections, Stroke, Symptoms Predictions and Brain Repair
Total Cost €
0EC-Contrib. €
0Partnership
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0DISCONNECTOME project word cloud
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Project "DISCONNECTOME" data sheet
The following table provides information about the project.
| Coordinator |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Organization address contact info |
| Coordinator Country | France [FR] |
| Total cost | 1˙999˙201 € |
| EC max contribution | 1˙999˙201 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2018-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-09-01 to 2024-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS | FR (PARIS) | coordinator | 1˙999˙201.00 |
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Project objective
Every year a brain stroke will impair approximately 2 million Europeans. Notwithstanding recent progress, many of these individuals will have persistent cognitive deficits, impacting their personality, degrading their quality of life and preventing their return to work. Early identification of anatomical predictors of brain recovery may significantly reduce the burden of these deficits on patients, their families and wider society, while also leading to the discovery of new targets for treatments. I have pioneered the development of imaging techniques that allow for the exploration of the relationship between brain disconnection and neuropsychological syndromes. With these tools, I aim to demonstrate that the structural organisation of the human brain's connections is the common denominator supporting functional specialisation and, when damaged, neuropsychological disorders. Building on my expertise, I plan to (1) establish an atlas mapping the function of white matter for the entire human brain, (2) fractionate the stroke population according to disconnection profiles, (3) predict neuropsychological symptoms based on disconnection profiles, and (4) characterise and manipulate the fine biology involved in the disconnection recovery.In so doing, this project will introduce a paradigm shift in the relationship between brain structure, function and behavioural/cognitive disorders. I will deliver a comprehensive biological model of the neurocircuitry that supports neuropsychological syndromes, which will gather the modular organisation of primary idiotypic functions with the integrative organisation of highly associative levels of functions. In the long term, this project will allow me to determine if measures of brain ‘connectivity’ can be translated into advanced standard procedures that provide for a more personalised medicine, that focuses upon rehabilitation and improving the prediction of symptom recovery, while providing new targets for pharmacological treatment.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Stefano Ioannucci, Nathalie George, Patrick Friedrich, Leonardo Cerliani, Michel Thiebaut de Schotten White matter correlates of hemi-face dominance in happy and sad expression published pages: , ISSN: 1863-2653, DOI: 10.1007/s00429-020-02040-7 |
Brain Structure and Function | 2020-04-15 |
| 2019 |
Michel Thiebaut de Schotten, Paula L. Croxson, Rogier B. Mars Large-scale comparative neuroimaging: Where are we and what do we need? published pages: 188-202, ISSN: 0010-9452, DOI: 10.1016/j.cortex.2018.11.028 |
Cortex 118 | 2020-04-15 |
| 2020 |
Stephanie J Forkel, Michel Thiebaut de Schotten Towards metabolic disconnection – symptom mapping published pages: 718-721, ISSN: 0006-8950, DOI: 10.1093/brain/awaa060 |
Brain 143/3 | 2020-04-15 |
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The information about "DISCONNECTOME" are provided by the European Opendata Portal: CORDIS opendata.
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