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FUNTRICAN SIGNED

Functional analysis of thyroid hormone nuclear receptors TRs in human Intestinal Cancer stem cells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FUNTRICAN project word cloud

Explore the words cloud of the FUNTRICAN project. It provides you a very rough idea of what is the project "FUNTRICAN" about.

enforce    signature    women    prerequisite    thyroid    final    crc    underlying    cell    plasticity    pool    ratio    experiments    mapping    cultures    stemness    diagnosed    genes    men    3d    modification    notch    determinant    issue    colosphere    elusive    therapeutic    predict    worldwide    cancer    relapse    proteome    adaptability    tumor    hormones    avenues    surgery    pave    wnt    recurrence    relies    strategy    human    ex    decades    cancers    standard    intestinal    escape    spread    chemotherapy    csc    profound    cscs    reduce    disrupting    combining    preliminary    patients    cells    life    statistically    eradicate    scores    threatens    deep    resistance    therapies    medical    bioid    downstream    stress    demonstrated    tend    innovative    risk    techniques    associate    limit    vivo    expression    minoring    original    differentiation    constitute    tr    tracing    ths    unable    apex2    crcs    colorectal    despite    body    trs    stem    focal    beta    parts    sc    area    alpha    conventional    players    balance    documented    organoid    premature    mechanisms    radiation    scs   

Project "FUNTRICAN" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 116˙953 €
 EC max contribution 116˙953 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 116˙953.00

Map

 Project objective

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in both men and women worldwide. Although some CRCs are effectively treated through the standard strategy of surgery, radiation and/or chemotherapy, some patients have a recurrence of their cancer and a spread to other parts of the body that threatens life. Despite decades of research, we are unable to predict which cancers will be effectively treated and which are likely to spread. In support of the well-documented resistance of cancer stem cells (CSCs) to conventional therapies high stem cell (SC) signature scores statistically associate with a high risk of tumor relapse in patients. Targeting CSCs thus constitute a determinant medical issue and identify novel players of SC plasticity is a prerequisite to open novel therapeutic avenues. Using ex vivo organoid cultures, we recently demonstrated that thyroid hormones (THs) reduce the pool of intestinal SCs by triggering premature cell differentiation. Even if the underlying mechanisms remain elusive, our preliminary results tend to demonstrate that the TH-induced loss of stemness relies on a profound modification of the ratio between TRα1 and TRβ1 (TRs), with deep consequences on the expression of WNT and NOTCH downstream target genes. My proposal will pave the way for a unique focal area in the field of CSCs. Combining original approaches such as ex vivo 3D human colosphere and organoid cultures, in vivo CSC tracing experiments as well as innovative proteome mapping techniques (BioID and APEX2) I aim to address the potential interest of disrupting the THs/TRs balance in order to enforce CSC differentiation with the final aim to eradicate them by conventional therapies. Furthermore and more importantly, by minoring CSC plasticity, it will strongly reduce their adaptability to stress conditions and limit escape mechanisms.

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The information about "FUNTRICAN" are provided by the European Opendata Portal: CORDIS opendata.

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