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FUNTRICAN SIGNED

Functional analysis of thyroid hormone nuclear receptors TRs in human Intestinal Cancer stem cells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FUNTRICAN project word cloud

Explore the words cloud of the FUNTRICAN project. It provides you a very rough idea of what is the project "FUNTRICAN" about.

cscs    ratio    colorectal    combining    vivo    3d    cells    modification    women    bioid    spread    unable    signature    recurrence    downstream    standard    mapping    scs    avenues    beta    original    risk    enforce    intestinal    men    csc    relapse    cell    profound    hormones    premature    medical    cancers    relies    proteome    preliminary    tracing    predict    stress    deep    apex2    tr    worldwide    statistically    stemness    conventional    reduce    limit    body    demonstrated    cultures    human    issue    pool    disrupting    final    patients    determinant    cancer    surgery    escape    associate    sc    organoid    wnt    adaptability    differentiation    trs    therapeutic    tumor    underlying    crcs    ths    resistance    innovative    minoring    ex    plasticity    prerequisite    radiation    experiments    notch    area    threatens    elusive    focal    stem    players    therapies    chemotherapy    eradicate    strategy    genes    despite    alpha    techniques    constitute    colosphere    parts    diagnosed    life    balance    expression    thyroid    pave    crc    documented    decades    tend    mechanisms    scores   

Project "FUNTRICAN" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 116˙953 €
 EC max contribution 116˙953 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 116˙953.00

Map

 Project objective

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in both men and women worldwide. Although some CRCs are effectively treated through the standard strategy of surgery, radiation and/or chemotherapy, some patients have a recurrence of their cancer and a spread to other parts of the body that threatens life. Despite decades of research, we are unable to predict which cancers will be effectively treated and which are likely to spread. In support of the well-documented resistance of cancer stem cells (CSCs) to conventional therapies high stem cell (SC) signature scores statistically associate with a high risk of tumor relapse in patients. Targeting CSCs thus constitute a determinant medical issue and identify novel players of SC plasticity is a prerequisite to open novel therapeutic avenues. Using ex vivo organoid cultures, we recently demonstrated that thyroid hormones (THs) reduce the pool of intestinal SCs by triggering premature cell differentiation. Even if the underlying mechanisms remain elusive, our preliminary results tend to demonstrate that the TH-induced loss of stemness relies on a profound modification of the ratio between TRα1 and TRβ1 (TRs), with deep consequences on the expression of WNT and NOTCH downstream target genes. My proposal will pave the way for a unique focal area in the field of CSCs. Combining original approaches such as ex vivo 3D human colosphere and organoid cultures, in vivo CSC tracing experiments as well as innovative proteome mapping techniques (BioID and APEX2) I aim to address the potential interest of disrupting the THs/TRs balance in order to enforce CSC differentiation with the final aim to eradicate them by conventional therapies. Furthermore and more importantly, by minoring CSC plasticity, it will strongly reduce their adaptability to stress conditions and limit escape mechanisms.

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The information about "FUNTRICAN" are provided by the European Opendata Portal: CORDIS opendata.

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