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FUNTRICAN SIGNED

Functional analysis of thyroid hormone nuclear receptors TRs in human Intestinal Cancer stem cells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FUNTRICAN project word cloud

Explore the words cloud of the FUNTRICAN project. It provides you a very rough idea of what is the project "FUNTRICAN" about.

decades    therapeutic    thyroid    resistance    combining    stem    threatens    tend    players    adaptability    mechanisms    preliminary    despite    pool    cscs    genes    diagnosed    signature    final    human    ratio    therapies    expression    scs    ex    balance    relies    minoring    eradicate    statistically    organoid    surgery    risk    men    associate    patients    medical    body    plasticity    innovative    escape    colorectal    demonstrated    apex2    original    tr    mapping    elusive    crcs    sc    differentiation    notch    alpha    cultures    parts    proteome    documented    experiments    prerequisite    premature    determinant    downstream    conventional    stress    beta    disrupting    worldwide    tumor    colosphere    pave    radiation    deep    cell    tracing    recurrence    standard    ths    relapse    hormones    cancer    crc    modification    intestinal    underlying    scores    enforce    life    bioid    strategy    limit    avenues    reduce    3d    women    chemotherapy    constitute    techniques    wnt    unable    vivo    stemness    spread    trs    area    focal    profound    cells    issue    csc    cancers    predict   

Project "FUNTRICAN" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 116˙953 €
 EC max contribution 116˙953 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 116˙953.00

Map

 Project objective

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in both men and women worldwide. Although some CRCs are effectively treated through the standard strategy of surgery, radiation and/or chemotherapy, some patients have a recurrence of their cancer and a spread to other parts of the body that threatens life. Despite decades of research, we are unable to predict which cancers will be effectively treated and which are likely to spread. In support of the well-documented resistance of cancer stem cells (CSCs) to conventional therapies high stem cell (SC) signature scores statistically associate with a high risk of tumor relapse in patients. Targeting CSCs thus constitute a determinant medical issue and identify novel players of SC plasticity is a prerequisite to open novel therapeutic avenues. Using ex vivo organoid cultures, we recently demonstrated that thyroid hormones (THs) reduce the pool of intestinal SCs by triggering premature cell differentiation. Even if the underlying mechanisms remain elusive, our preliminary results tend to demonstrate that the TH-induced loss of stemness relies on a profound modification of the ratio between TRα1 and TRβ1 (TRs), with deep consequences on the expression of WNT and NOTCH downstream target genes. My proposal will pave the way for a unique focal area in the field of CSCs. Combining original approaches such as ex vivo 3D human colosphere and organoid cultures, in vivo CSC tracing experiments as well as innovative proteome mapping techniques (BioID and APEX2) I aim to address the potential interest of disrupting the THs/TRs balance in order to enforce CSC differentiation with the final aim to eradicate them by conventional therapies. Furthermore and more importantly, by minoring CSC plasticity, it will strongly reduce their adaptability to stress conditions and limit escape mechanisms.

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The information about "FUNTRICAN" are provided by the European Opendata Portal: CORDIS opendata.

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