#	Pagina
attuale pagina	/open-h2020/projects/223067/index.html

Opendata, web and dolomites

LC-FMRI SIGNED

Deciphering the effects of locus coeruleus activity on whole-brain dynamics and neurovascular coupling

Total Cost €

EC-Contrib. €

Partnership

Views

LC-FMRI project word cloud

Explore the words cloud of the LC-FMRI project. It provides you a very rough idea of what is the project "LC-FMRI" about.

calcium small vascular context behavior decipher mice experiments astrocytic optogenetic human contributions modulates anesthesia dynamics ultra function effect autonomous imaging clinical foundation performed stimulation circumvent imperative sensory coeruleus functional neurons cognitive neural connections disorders perform resonance groups confounding neurovascular brain gained lay broad acquire psychiatric locus endpoint lc health reconfiguration downstream regulates optical recordings network simultaneous vital comprehensively disease translation fmri functions neurodegenerative magnetic awake coupling

Project "LC-FMRI" data sheet

The following table provides information about the project.

Coordinator	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD Organization address address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD city: LISBOA postcode: 1400-038 website: http://fchampalimaud.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	147˙815 €
EC max contribution	147˙815 € (100%)
Programme	1. H2020-EU.4. (SPREADING EXCELLENCE AND WIDENING PARTICIPATION)
Code Call	H2020-WF-01-2018
Funding Scheme	MSCA-IF-EF-ST
Starting year	2019
Duration (year-month-day)	from 2019-09-01 to 2021-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD Organization address address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD city: LISBOA postcode: 1400-038 website: http://fchampalimaud.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	147˙815.00

Map

Project objective

Locus coeruleus (LC) regulates vital autonomous and cognitive functions and has recently gained interest as a clinical target in neurodegenerative and psychiatric disorders. Previous studies have investigated the effect of LC activity on small groups of neurons and on endpoint behavior. However, LC’s widespread connections and broad downstream effects make a systems-level approach imperative for comprehensively understanding LC function. In LC-FMRI, we will perform highly specific optogenetic LC stimulation in mice and assess whole-brain responses and functional network reconfiguration using ultra-high field functional magnetic resonance imaging (fMRI). To decipher neural, astrocytic and vascular contributions to LC-induced fMRI responses, we will acquire simultaneous optical calcium recordings during fMRI. Experiments will be performed in awake mice to circumvent confounding effects of anesthesia on LC function. Finally, we will investigate how LC stimulation affects whole-brain dynamics and neurovascular coupling in the context of sensory processing. Our project will lay the foundation for studying how LC modulates whole-brain dynamics in health and disease using fMRI, with high potential for translation to human applications.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LC-FMRI" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LC-FMRI" are provided by the European Opendata Portal: CORDIS opendata.