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SSINGERG SIGNED

Solid-phase synthesis of imprinted nanoparticles exhibiting glycan epitope recognition in glycoproteins

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SSINGERG project word cloud

Explore the words cloud of the SSINGERG project. It provides you a very rough idea of what is the project "SSINGERG" about.

entities    cope    size    either    outputs    filled    acetylgalactosamine    incubation    prepared    binding    imprinted    recognition    glycan    receptors    immobilized    nanomips    glycoproteome    polymer    nanoparticles    preparation    particles    competitive    manner    routes    monosaccharide    generate    throughput    plastic    solubility    gel    setting    synthesis    mixture    exhibiting    glycoprotein    reactor    glyproteins    ascertained    near    highest    data    patentable    immobilization    mixtures    derive    solid    protocol    specificity    subsequent    sorption    behaving    enrichment    containing    critical    subclasses    incorporated    onto    batch    standalone    column    silica    phases    affinity    acetylglucosamine    synthetic    supporting    found    combined    diseases    protocols    beads    glycoproteins    combinations    sol    instrumentation    myriad    temperature    reproducibility    mannose    isotherm    selectivity    consisting    capacity    limitations    performance    cell    polymerization    automated    nanoreceptors    acetlgalactosamine    criteriously    optimum    antibodies    nanomip    biology    screened    monosaccharides    epitope    play    glass    imprinting   

Project "SSINGERG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE DO PORTO 

Organization address
address: PRACA GOMES TEIXEIRA
city: PORTO
postcode: 4099 002
website: http://www.up.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 147˙815 €
 EC max contribution 147˙815 € (100%)
 Programme 1. H2020-EU.4. (SPREADING EXCELLENCE AND WIDENING PARTICIPATION)
 Code Call H2020-WF-01-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO PORTO PT (PORTO) coordinator 147˙815.00

Map

 Project objective

The present project aims at the preparation of synthetic nanoreceptors exhibiting glycan epitope recognition in glycoproteins, identified to play a critical role in cell biology and diseases. Such nanoreceptors, behaving like antibodies, may cope with the current limitations in the essential step of enrichment of specific glycan subclasses, within studies of the glycoproteome. The preparation of the receptors will proceed through solid-phase synthesis of imprinted polymer nanoparticles, with the potential to deliver entities with size, specificity and solubility characteristics comparable to antibodies. The solid-phase synthesis of NanoMIP will require the immobilization of important monosaccharides (N-acetylglucosamine, N-acetlgalactosamine, mannose), widely found in glycoproteins, onto supporting beads. Several synthetic routes will be studied for the immobilization onto silica or plastic beads . In a reactor, built as a controlled temperature glass column filled with the beads containing immobilized monosaccharide, criteriously selected polymerization or sol-gel mixtures will generate the nanoMIPs, with subsequent selection of the highest affinity particles. The optimum combinations of solid-phase/imprinting protocol will be screened from a myriad of nanoMIPs prepared in different conditions. The performance of the nanoMIPs will be ascertained by setting a competitive enrichment protocol consisting of the incubation with a mixture of N-acetylglucosamine-, N-acetylgalactosamine- and mannose-containing glyproteins and a non-glycoprotein. Sorption isotherm data will be used to derive important binding features such as capacity, binding affinity and selectivity. Patentable robust solid-phases and imprinting protocols, either in standalone or combined manner, are planned outputs of the project, which may, in the near future, be incorporated into existing automated solid-phase synthesis instrumentation, for increased throughput and batch reproducibility.

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The information about "SSINGERG" are provided by the European Opendata Portal: CORDIS opendata.

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