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SSINGERG SIGNED

Solid-phase synthesis of imprinted nanoparticles exhibiting glycan epitope recognition in glycoproteins

Total Cost €

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EC-Contrib. €

0

Partnership

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 SSINGERG project word cloud

Explore the words cloud of the SSINGERG project. It provides you a very rough idea of what is the project "SSINGERG" about.

antibodies    solubility    entities    near    onto    generate    imprinting    polymerization    sorption    cell    exhibiting    biology    acetylglucosamine    mixtures    sol    play    outputs    batch    incubation    criteriously    routes    glycoproteins    particles    isotherm    manner    immobilized    ascertained    preparation    reactor    competitive    myriad    standalone    nanoreceptors    optimum    combinations    binding    mixture    glycan    behaving    setting    data    incorporated    temperature    subsequent    monosaccharide    supporting    imprinted    capacity    polymer    diseases    enrichment    specificity    glass    protocol    screened    solid    either    immobilization    automated    epitope    column    synthetic    cope    glycoproteome    glyproteins    found    subclasses    reproducibility    nanomip    critical    gel    recognition    patentable    combined    instrumentation    filled    highest    containing    nanoparticles    limitations    glycoprotein    monosaccharides    acetlgalactosamine    size    performance    consisting    silica    throughput    phases    protocols    prepared    nanomips    acetylgalactosamine    synthesis    derive    mannose    plastic    beads    selectivity    affinity    receptors   

Project "SSINGERG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE DO PORTO 

Organization address
address: PRACA GOMES TEIXEIRA
city: PORTO
postcode: 4099 002
website: http://www.up.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 147˙815 €
 EC max contribution 147˙815 € (100%)
 Programme 1. H2020-EU.4. (SPREADING EXCELLENCE AND WIDENING PARTICIPATION)
 Code Call H2020-WF-01-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO PORTO PT (PORTO) coordinator 147˙815.00

Map

 Project objective

The present project aims at the preparation of synthetic nanoreceptors exhibiting glycan epitope recognition in glycoproteins, identified to play a critical role in cell biology and diseases. Such nanoreceptors, behaving like antibodies, may cope with the current limitations in the essential step of enrichment of specific glycan subclasses, within studies of the glycoproteome. The preparation of the receptors will proceed through solid-phase synthesis of imprinted polymer nanoparticles, with the potential to deliver entities with size, specificity and solubility characteristics comparable to antibodies. The solid-phase synthesis of NanoMIP will require the immobilization of important monosaccharides (N-acetylglucosamine, N-acetlgalactosamine, mannose), widely found in glycoproteins, onto supporting beads. Several synthetic routes will be studied for the immobilization onto silica or plastic beads . In a reactor, built as a controlled temperature glass column filled with the beads containing immobilized monosaccharide, criteriously selected polymerization or sol-gel mixtures will generate the nanoMIPs, with subsequent selection of the highest affinity particles. The optimum combinations of solid-phase/imprinting protocol will be screened from a myriad of nanoMIPs prepared in different conditions. The performance of the nanoMIPs will be ascertained by setting a competitive enrichment protocol consisting of the incubation with a mixture of N-acetylglucosamine-, N-acetylgalactosamine- and mannose-containing glyproteins and a non-glycoprotein. Sorption isotherm data will be used to derive important binding features such as capacity, binding affinity and selectivity. Patentable robust solid-phases and imprinting protocols, either in standalone or combined manner, are planned outputs of the project, which may, in the near future, be incorporated into existing automated solid-phase synthesis instrumentation, for increased throughput and batch reproducibility.

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The information about "SSINGERG" are provided by the European Opendata Portal: CORDIS opendata.

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