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MOVEMeNt SIGNED

Decoding alpha motor neurons diversity and selective vulnerability to disease

Total Cost €

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EC-Contrib. €

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Partnership

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 MOVEMeNt project word cloud

Explore the words cloud of the MOVEMeNt project. It provides you a very rough idea of what is the project "MOVEMeNt" about.

mice    therapeutic    movement    overreaching    identity    mouse    harvard    degenerates    aim2    candidates    cell    degenerating    host    shape    normally    dissecting    amn    functional    lateral    strategies    integrate    ff    underlying    remodeling    achievement    resistant    ffr    markers    roles    vivo    vulnerability    insult    analyze    therapy    sfr    fingerprints    diseases    transcriptional    background    atrophy    vulnerable    transcriptomic    critical    degenerate    roadmap    nuclei    classes    function    first    logics    return    generating    als    sbma    neuronal    pioneered    rate    population    neurons    fatigable    university    motor    purify    sclerosis    subtypes    skills    undertaking    differentially    cords    molecular    expression    bulbar    amyotrophic    candidate    selective    mns    pinpointing    genes    harmonically    suptype    muscular    mechanisms    denervation    amns    playing    retrograde    spinal    adult    successful    intoxication    facs    single    technologies    class    fast    clinically    neuromuscular    solid    compensation    broadly    sprouting    filling    selectively    reveal    isolate    neurotoxin    gap    labeling    terminal    alpha    substrate    disease   

Project "MOVEMeNt" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PADOVA 

Organization address
address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122
website: www.unipd.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) coordinator 183˙473.00

Map

 Project objective

Alpha motor neurons (aMN) are a clinically relevant neuronal population that selectively degenerates in neuromuscular diseases, including amyotrophic lateral sclerosis (ALS) and spinal bulbar muscular atrophy (SBMA). Distinct classes of aMNs (SFR, FFR and FF) degenerate at different rate in these diseases, with the fast fatigable (FF) MNs degenerating first. The molecular mechanisms underlying this selective vulnerability are only partially known. Understanding the molecular logics that shape the identity and function of aMN subtypes in vivo is directly relevant to the development of novel therapeutic strategies. Here I propose to harmonically integrate my solid background in dissecting the molecular fingerprints of distinct neuronal subtypes in adult mice by undertaking new technologies I pioneered at Harvard University, with new skills and knowledge I will build at the Host Institution, which will be critical for the successful achievement of my goal. The overreaching goal of MOVEMeNt is to identify the molecular substrate of disease vulnerability in aMNs. I will (Aim 1) isolate and FACS-purify aMN-nuclei from adult mouse spinal cords, based on the specific expression of aMN markers. Single cell transcriptomic analysis will reveal class-specific molecular fingerprints, including factors playing key roles in suptype-specific development, function, and disease vulnerability. I will also (Aim2) analyze the transcriptional changes of differentially vulnerable aMN classes upon retrograde labeling and functional denervation by neurotoxin intoxication. This work will return candidate genes directly controlling terminal sprouting and remodeling, critical steps that disease-resistant aMN subtypes normally undertake for neuronal loss compensation upon insult. More broadly, I aim to contribute in filling an important knowledge gap by generating the first transcriptomic roadmap of aMN subtypes, and pinpointing at new candidates for therapy development.

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The information about "MOVEMENT" are provided by the European Opendata Portal: CORDIS opendata.

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