Opendata, web and dolomites

MOVEMeNt SIGNED

Decoding alpha motor neurons diversity and selective vulnerability to disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MOVEMeNt project word cloud

Explore the words cloud of the MOVEMeNt project. It provides you a very rough idea of what is the project "MOVEMeNt" about.

adult    therapy    pioneered    therapeutic    successful    labeling    harvard    motor    degenerates    transcriptomic    fast    amn    host    diseases    amns    denervation    degenerate    amyotrophic    bulbar    purify    return    ffr    intoxication    fingerprints    degenerating    vivo    selectively    neurotoxin    movement    single    logics    broadly    pinpointing    roles    solid    mice    playing    facs    sprouting    cell    background    mechanisms    spinal    vulnerable    rate    first    atrophy    genes    alpha    suptype    harmonically    underlying    mns    sfr    class    integrate    neuromuscular    neuronal    university    roadmap    mouse    vulnerability    cords    strategies    als    analyze    achievement    muscular    neurons    ff    sbma    fatigable    compensation    subtypes    clinically    generating    retrograde    reveal    expression    transcriptional    critical    technologies    classes    lateral    remodeling    candidates    disease    terminal    skills    population    resistant    functional    insult    gap    isolate    selective    nuclei    normally    differentially    function    sclerosis    shape    candidate    identity    dissecting    overreaching    molecular    aim2    substrate    undertaking    markers    filling   

Project "MOVEMeNt" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PADOVA 

Organization address
address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122
website: www.unipd.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) coordinator 183˙473.00

Map

 Project objective

Alpha motor neurons (aMN) are a clinically relevant neuronal population that selectively degenerates in neuromuscular diseases, including amyotrophic lateral sclerosis (ALS) and spinal bulbar muscular atrophy (SBMA). Distinct classes of aMNs (SFR, FFR and FF) degenerate at different rate in these diseases, with the fast fatigable (FF) MNs degenerating first. The molecular mechanisms underlying this selective vulnerability are only partially known. Understanding the molecular logics that shape the identity and function of aMN subtypes in vivo is directly relevant to the development of novel therapeutic strategies. Here I propose to harmonically integrate my solid background in dissecting the molecular fingerprints of distinct neuronal subtypes in adult mice by undertaking new technologies I pioneered at Harvard University, with new skills and knowledge I will build at the Host Institution, which will be critical for the successful achievement of my goal. The overreaching goal of MOVEMeNt is to identify the molecular substrate of disease vulnerability in aMNs. I will (Aim 1) isolate and FACS-purify aMN-nuclei from adult mouse spinal cords, based on the specific expression of aMN markers. Single cell transcriptomic analysis will reveal class-specific molecular fingerprints, including factors playing key roles in suptype-specific development, function, and disease vulnerability. I will also (Aim2) analyze the transcriptional changes of differentially vulnerable aMN classes upon retrograde labeling and functional denervation by neurotoxin intoxication. This work will return candidate genes directly controlling terminal sprouting and remodeling, critical steps that disease-resistant aMN subtypes normally undertake for neuronal loss compensation upon insult. More broadly, I aim to contribute in filling an important knowledge gap by generating the first transcriptomic roadmap of aMN subtypes, and pinpointing at new candidates for therapy development.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MOVEMENT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MOVEMENT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Photonic Radar (2019)

Implementation of Long Reach Hybrid Photonic Radar System and convergence over FSO and PON Networks

Read More  

CORRELATION (2020)

Characterization and prediction of service-level traffic for future sliced mobile network

Read More  

ReSOLeS (2019)

New Reconfigurable Spectrum Optical Fibre Laser Sources

Read More