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REMODEL SIGNED

Research models in infection, cancer and regeneration: replacement and translation

Total Cost €

EC-Contrib. €

Partnership

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REMODEL project word cloud

Explore the words cloud of the REMODEL project. It provides you a very rough idea of what is the project "REMODEL" about.

whilst organoids replacement participation establishment infection diseases staff demonstrating framework validating personalized combines training attractive move replace mentoring societal transferable fit meet spotlight conferences accounting organoid manipulating frontline capacitate experimental expertise models innovative i3s infectious place schools time scientific stage profile animal precision translational vitro methodological remodel tissue competence fragmentation translationally skills capacity local network medicine overcome presenting era international collaborations ibmc cancer purposes model biomedical biomedicine pressure context bioengineering customization experiments regeneration periods relevance themes issue

Project "REMODEL" data sheet

The following table provides information about the project.

Coordinator	INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC Organization address address: RUA ALFREDO ALLEN 208 city: PORTO postcode: 4200 135 website: www.ibmc.up.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	799˙647 €
EC max contribution	799˙647 € (100%)
Programme	1. H2020-EU.4.b. (Twinning of research institutions)
Code Call	H2020-WIDESPREAD-2018-03
Funding Scheme	CSA
Starting year	2019
Duration (year-month-day)	from 2019-11-01 to 2022-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC Organization address address: RUA ALFREDO ALLEN 208 city: PORTO postcode: 4200 135 website: www.ibmc.up.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (PORTO)	coordinator	314˙771.00
2	UNIVERSITEIT UTRECHT UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	190˙250.00
3	JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG Organization address address: SANDERRING 2 city: WUERZBURG postcode: 97070 website: http://www.uni-wuerzburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (WUERZBURG)	participant	185˙251.00
4	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	109˙375.00

Map

Project objective

REMODEL combines the existing local expertise in bioengineering, cancer and infectious diseases with partners at the frontline in developing organoid systems, manipulating them to fit specific purposes and validating their use as models, in order to build capacity to work with innovative model systems that can replace animal experiments and increase translational relevance. In doing so, REMODEL addresses a key issue in today’s biomedical research: how non-animal model systems can be developed to meet the needs for translationally relevant research in the era of precision and personalized medicine, whilst at the same time accounting for societal pressure to replace animal experiments. REMODEL will capacitate the coordinating institution, IBMC-i3S, through the establishment of organoid advanced in vitro models and their customization for the main areas of research (infection, cancer and tissue regeneration). REMODEL will contribute to raising the research profile of the institution and scientific skills of its staff developed through training schools and short-term scientific training periods as well as transferable skills training and mentoring of Early Stage researchers, but also through staff participation in international conferences presenting work within the REMODEL themes / framework. Organoids as experimental models are at the frontline of methodological development in biomedicine, and demonstrating competence in working with such models will place i3S in the spotlight in an international research context, and make the institution an attractive partner for future collaborations beyond the REMODEL network. On the European level, REMODEL represents an important initiative to bring together key partners in the development of innovative models to overcome the present fragmentation of European organoid research and move towards applications in animal replacement.

Publications

List of publications.
year	authors and title	journal	last update
2017	Kaori L. Fonseca, Pedro N. S. Rodrigues, I. Anna S. Olsson, Margarida Saraiva Experimental study of tuberculosis: From animal models to complex cell systems and organoids published pages: e1006421, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006421	PLOS Pathogens 13/8	2020-04-17
2019	Daniela Barros, Paula Parreira, Joana Furtado, Frederico Ferreira-da-Silva, Eduardo Conde-Sousa, AndrÃ©s J. GarcÃa, M. Cristina L. Martins, Isabel Freitas Amaral, Ana Paula PÃªgo An affinity-based approach to engineer laminin-presenting cell instructive microenvironments published pages: 601-611, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.10.039	Biomaterials 192	2020-04-17
2018	Meritxell BalmaÃ±a, Stefan Mereiter, Francisca Diniz, TÃ¡lia FeijÃ£o, Cristina Barrias, Celso Reis Multicellular Human Gastric Cancer Spheroids Mimic the Glycosylation Phenotype of Gastric Carcinomas published pages: 2815, ISSN: 1420-3049, DOI: 10.3390/molecules23112815	Molecules 23/11	2020-04-17
2017	Joana Silva, Ana R. Bento, Daniela Barros, Tiago L. Laundos, Susana R. Sousa, Pedro Quelhas, MÃ³nica M. Sousa, Ana P. PÃªgo, Isabel F. Amaral Fibrin functionalization with synthetic adhesive ligands interacting with Î±6Î²1 integrin receptor enhance neurite outgrowth of embryonic stem cell-derived neural stem/progenitors published pages: 243-256, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.07.013	Acta Biomaterialia 59	2020-04-17

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The information about "REMODEL" are provided by the European Opendata Portal: CORDIS opendata.