Opendata, web and dolomites
DBScontrol SIGNED
Implementation and preclinical testing of a closed-loop control system for deep brain stimulation
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0DBScontrol project word cloud
Explore the words cloud of the DBScontrol project. It provides you a very rough idea of what is the project "DBScontrol" about.
models
algorithms
device
clinically
disease
dbsmodel
feasibility
patients
biophysically
time
pulse
human
therapeutic
benefits
circuits
battery
frequency
operate
suboptimal
efficacy
proof
emerged
confirm
recognised
reducing
humans
brain
25
neural
pd
first
closed
alternative
prototype
empirically
clinical
offers
deep
life
treatment
translation
symptoms
mechanisms
animal
amplitude
fixed
model
despite
adjusting
over
parent
trialled
limitations
overcome
demonstrated
validation
automatically
dbs
programming
parkinson
stimulation
configuration
suitable
implementing
solution
erc
stimulus
computational
loop
poor
remaining
experimental
Project "DBScontrol" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Organization address contact info |
| Coordinator Country | Ireland [IE] |
| Total cost | 0 € |
| EC max contribution | 150˙000 € (0%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-PoC |
| Funding Scheme | ERC-POC-LS |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-03-02 to 2021-09-01 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN | IE (DUBLIN) | coordinator | 150˙000.00 |
Map
Project objective
Over the past 25 years deep brain stimulation (DBS) has emerged as an effective treatment for the symptoms of Parkinson's disease (PD). Despite its success, the mechanisms of DBS are not yet fully understood. Moreover, patients experience side effects and poor control of symptoms associated with suboptimal programming of stimulus parameters. Current DBS systems operate in an 'open-loop' configuration with stimulus parameters (pulse amplitude, duration and frequency) empirically set and remaining fixed over time. Closed-loop DBS offers an alternative approach that has the potential to overcome current limitations and increase therapeutic efficacy, while reducing side-effects and increasing battery life, by automatically adjusting stimulation parameters as required. Although the potential benefits of closed-loop DBS are widely recognised, these systems have not yet been implemented clinically. Under the parent ERC project DBSmodel, we have developed biophysically detailed computational models of the neural circuits in the brain during DBS and are using these to develop and test novel algorithms for closed-loop DBS. Before these can be trialled in humans, however, feasibility must first to be demonstrated through implementation on a prototype device and pre-clinical testing in animal models. ERC proof of concept funding will enable us to do this by implementing and testing a novel closed-loop DBS system in an animal model of PD. The experimental validation will confirm the efficacy of a prototype solution suitable for translation to human studies.
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The information about "DBSCONTROL" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-07-16 10:57:51) correctly updated