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RNADOMAIN SIGNED
Computational genomics of long noncoding RNA domains across metazoans
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0RNADOMAIN project word cloud
Explore the words cloud of the RNADOMAIN project. It provides you a very rough idea of what is the project "RNADOMAIN" about.
separable
compartments
database
resource
domains
readily
involvement
machine
protein
computational
maps
complement
sequence
dna
nevertheless
from
19
experimental
estimates
regulation
throughput
statistical
fundamental
designed
encoded
shown
rna
contains
putative
interesting
lncrna
transposable
stored
junk
learning
databases
genomic
point
coding
accessible
genes
first
intimately
functional
efforts
queried
disease
foundational
lastly
mechanistic
predict
localisation
community
candidates
inert
proteins
functions
disseminated
biological
noncoding
genomes
algorithms
surprises
metazoan
insights
25
rnas
shed
unsolved
arduous
genome
full
light
experimentally
dark
subcellular
discoveries
road
encode
cancer
validate
function
lncrnas
primary
employed
updated
map
Project "RNADOMAIN" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAET BERN
Organization address contact info |
| Coordinator Country | Switzerland [CH] |
| Total cost | 203˙149 € |
| EC max contribution | 203˙149 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2019 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2021 |
| Duration (year-month-day) | from 2021-07-01 to 2023-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAET BERN | CH (BERN) | coordinator | 203˙149.00 |
Map
Project objective
From junk DNA to genomic dark matter, the road to understanding RNAs that do not encode for proteins has been full of surprises. Compared to 19,000 protein-coding genes, recent estimates point that our genome contains between 25,000 and 100,000 long noncoding RNA (lncRNA) genes. Far from being inert, some lncRNAs are involved in development and disease, particularly, cancer. It has also been shown that the function of a lncRNA can be associated with its localisation in subcellular compartments. Nevertheless, to experimentally characterize and validate interesting lncRNAs is an arduous task. Computational approaches based on machine learning could be designed to complement and scale-up such efforts. Based on recent experimental discoveries, it has been proposed that lncRNAs are separable into functional domains, and that these domains are intimately related to transposable elements and repeats. Nevertheless, how functions are encoded in primary RNA sequence is a fundamental unsolved problem. I propose to develop the first high-throughput computational approach to map lncRNA domains across metazoan genomes. Domains will be first identified according to statistical evidence supported by current biological insights. Putative domains will be queried against state-of-the-art databases on lncRNA function, localisation, and disease. Machine learning algorithms will then be employed to predict new functional domains, and new mechanistic insights will be offered for promising candidates. Lastly, the obtained maps will be stored and disseminated in a database, that will be regularly updated and readily accessible for the research community. This will be a foundational resource to finally shed light on the role of lncRNAs, their regulation and involvement in disease.
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The information about "RNADOMAIN" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-07-16 10:39:26) correctly updated