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ObeSIK3 SIGNED

Role of SIK3 in energy homeostasis

Total Cost €

0

EC-Contrib. €

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Partnership

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 ObeSIK3 project word cloud

Explore the words cloud of the ObeSIK3 project. It provides you a very rough idea of what is the project "ObeSIK3" about.

phenotype    edge    decades    last    molecular    13    phosphoproteomics    sensor    techniques    cns    homeostasis    seq    kinase    ex13    animal    characterization    pathophysiology    flox    combination    discover    neuron    search    therapy    funato    exon    obesity    defective    interrelationship    health    uncover    anti    cutting    obese    splicing    energy    metabolic    regulation    central    action    mutation    lab    models    nervous    inducible    burden    sik3    yanagisawa    relation    therapeutic    rna    functionally    suitability    influence    sleep    mice    disorders    gene    mutant    hence    balance    salt    understand    genetics    sum    line    virogenetic   

Project "ObeSIK3" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA    more Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	253˙227 €
EC max contribution	253˙227 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2019
Funding Scheme	MSCA-IF-GF
Starting year	2021
Duration (year-month-day)	from 2021-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA × UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a. Close	ES (SANTIAGO DE COMPOSTELA)	coordinator	253˙227.00
2	UNIVERSITY OF TSUKUBA × UNIVERSITY OF TSUKUBA Organization address address: TENNO DAI ,TSUKUBA SHI 1 1 1 city: TSUKUBA IBARAKI postcode: 305 8577 website: www.life.tsukuba.ac.jp/en/index.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a. Close	JP (TSUKUBA IBARAKI)	partner	0.00

Map

 Project objective

In the last decades, obesity has become a growing health burden hence the importance of understanding its pathophysiology and the need to search for new therapeutic targets. Yanagisawa/Funato Lab (Y/F Lab) has recently discover that a splicing mutation in the Salt-inducible kinase 3 (Sik3) gene is involved in determining sleep need , and as well in a likely defective energy homeostasis since mice mutant for exon 13 of the Sik3 gene present an obese phenotype. The main objective of my proposed action is to identify the role of SIK3 in the central nervous system (CNS) in the regulation of energy balance and study its suitability as a target to develop an anti-obesity therapy. To achieve this, I will use virogenetic approaches in Sik3-ex13 flox mice and a neuron-specific mutant mice line for exon 13 of Sik3 gene will be generated. The molecular characterization of the animal models will be conducted by using several cutting-edge techniques such as RNA-Seq and phosphoproteomics. The identified targets will be functionally analyzed using genetics approaches. In sum, by doing the proposed project I will expect to uncover the influence of a potential new sensor in metabolic homeostasis. Moreover, this work in combination with the one going already on in Y/F Lab in relation to sleep may allow to understand the interrelationship between sleep disorders and obesity.

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The information about "OBESIK3" are provided by the European Opendata Portal: CORDIS opendata.

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