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GermAge SIGNED

The aging germ cell – biological pathways, risk factors and mechanisms underlying an increasing medical and socio-economic problem

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

GermAge project word cloud

Explore the words cloud of the GermAge project. It provides you a very rough idea of what is the project "GermAge" about.

mutation health dramatically public basis synergetic stem cell urgent decline welfare female decay germage declining innovative load biological socio risks frozen societal reproductive quality germ infertility mechanisms mutations individualized diseases agenda demographic biomarkers mouse cohesins inheritance checkpoint devastating determinants mostly oocytes assembly severe insights grave carriers male societies parenthood steep cells fertility contribution proboems spindle aging spermatogonial gametogenesis medicine understand inherited population aneuploidie aneuploidy postponing dependent human spermatocytes diagnostics genomics severely structure economic prioritization techniques medical vitro proteins risk prognosis delayed age chromosome fertilization

Project "GermAge" data sheet

The following table provides information about the project.

Coordinator	TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.germage.eu
Total cost	5˙350˙598 €
EC max contribution	5˙350˙598 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2020-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITAET DRESDEN TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	coordinator	1˙330˙000.00
2	UNIVERSITY OF NEWCASTLE UPON TYNE UNIVERSITY OF NEWCASTLE UPON TYNE Organization address address: KINGS GATE city: NEWCASTLE UPON TYNE postcode: NE1 7RU website: http://www.ncl.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NEWCASTLE UPON TYNE)	participant	1˙472˙280.00
3	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	1˙284˙375.00
4	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	1˙263˙943.00

Map

Project objective

The main objective of GermAge is to understand the devastating decline in germ cell quality during aging, and thus to define the determinants, pathways and risk factors for age-dependent infertility, aneuploidy and inherited diseases. The aging population and the dramatically increasing age of parenthood are associated with grave medical problems, declining reproductive health, and severe consequences for the socio-economic well-being of our societies. These proboems will impact the demographic structure and societal welfare in the European population. Thus the urgent need to understand the biological basis and to identify risk factors and pathways of the steep age-dependent decline in female and male germ cell quality. GermAge will address mostly the aging female gametogenesis known to be most severely affected by aging, but also the important contribution of aging male germ cells to age-related fertility and inheritance problems. The decay of key chromosome proteins such as cohesins, the failure of quality control mechanisms such as the spindle assembly checkpoint, and the mutation load in aging spermatogonial stem cells are among the highly synergetic research topics of GermAge. Mouse and human germ cells will be analyzed by high-end and innovative techniques. The expected insights will eventually lead to much improved diagnostics in various reproductive medicine procedures such as quality control of germ cells frozen for delayed in vitro fertilization, development of new biomarkers for oocytes, risk assessment for inherited diseases including aneuploidie in carriers of specific mutations, and prognosis based on individualized genomics on age-related quality decline of oocytes and spermatocytes. We also expect that our findings will raise awareness of the risks associated with postponing parenthood, leading to a much-needed prioritization on the public health agenda.

Deliverables

List of deliverables.
Public web site	Websites, patent fillings, videos etc.	2020-01-24 08:58:19

Take a look to the deliverables list in detail: detailed list of GermAge deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Anna Kouznetsova, Tomoya S Kitajima, Hjalmar Brismar, Christer HÃ¶Ã¶g Postâ€metaphase correction of aberrant kinetochoreâ€microtubule attachments in mammalian eggs published pages: , ISSN: 1469-221X, DOI: 10.15252/embr.201947905	EMBO reports 20/8	2020-01-24
2018	Ana Agostinho, Anna Kouznetsova, Abrahan HernÃ¡ndez-HernÃ¡ndez, Kristoffer Bernhem, Hans Blom, Hjalmar Brismar, Christer HÃ¶Ã¶g Sexual dimorphism in the width of the mouse synaptonemal complex published pages: jcs212548, ISSN: 0021-9533, DOI: 10.1242/jcs.212548	Journal of Cell Science 131/5	2020-01-24
2018	Uddipta Biswas, Michelle Stevense, Rolf Jessberger SMC1Î± Substitutes for Many Meiotic Functions of SMC1Î² but Cannot Protect Telomeres from Damage published pages: 249-261.e4, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.12.020	Current Biology 28/2	2020-01-24
2016	Ana Agostinho, Otto Manneberg, Robin van Schendel, Abrahan HernÃ¡ndezâ€HernÃ¡ndez, Anna Kouznetsova, Hans Blom, Hjalmar Brismar, Christer HÃ¶Ã¶g High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation published pages: 901-913, ISSN: 1469-221X, DOI: 10.15252/embr.201642030	EMBO reports 17/6	2020-01-24
2017	Rolf Jessberger GermAge, The aging germ cell ? biological pathways, risk factors and mechanisms underlying anincreasing medical and socio-economic problem, HORIZON2020 published pages: 15-17, ISSN: 2398-7073, DOI: 10.21820/23987073.2017.10.15	Impact 2017/10	2020-01-24
2017	Mary Herbert, Attila Toth How Meiosis Creates the Single-Copy Genome published pages: 3-4, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2016.12.019	Developmental Cell 40/1	2020-01-24
2015	Mary Herbert, Dimitrios Kalleas, Daniel Cooney, Mahdi Lamb, Lisa Lister Meiosis and Maternal Aging: Insights from Aneuploid Oocytes and Trisomy Births published pages: a017970, ISSN: 1943-0264, DOI: 10.1101/cshperspect.a017970	Cold Spring Harbor Perspectives in Biology 7/4	2020-01-24
2017	Ahmed Rattani, Randy Ballesteros Mejia, Katherine Roberts, Maurici B. Roig, Jonathan Godwin, Michael Hopkins, Manuel Eguren, Luis Sanchez-Pulido, Elwy Okaz, Sugako Ogushi, Magda Wolna, Jean Metson, Alberto M. PendÃ¡s, Marcos Malumbres, BÃ©la NovÃ¡k, Mary Herbert, Kim Nasmyth APC/C Cdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity published pages: 1462-1476.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.04.023	Current Biology 27/10	2020-01-24
2016	Abrahan HernÃ¡ndez-HernÃ¡ndez, Ingrid Lilienthal, Nanaho Fukuda, Niels Galjart, Christer HÃ¶Ã¶g CTCF contributes in a critical way to spermatogenesis and male fertility published pages: , ISSN: 2045-2322, DOI: 10.1038/srep28355	Scientific Reports 6/1	2020-01-24

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The information about "GERMAGE" are provided by the European Opendata Portal: CORDIS opendata.