SYBORG SIGNED
combining SYnthetic Biology and chemistry to create novel CO2-fixing enzymes, ORGanelles and ORGanisms
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0EC-Contrib. €
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Project "SYBORG" data sheet
The following table provides information about the project.
| Coordinator |
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Project website | http://www.mpi-marburg.mpg.de/erb |
| Total cost | 1˙746˙038 € |
| EC max contribution | 1˙746˙038 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-05-01 to 2020-04-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV | DE (MUENCHEN) | coordinator | 1˙746˙038.00 |
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Project objective
'Carbon dioxide (CO2) is a potent greenhouse gas whose presence in the atmosphere is a critical factor for global warming. At the same time atmospheric CO2 is a cheap and readily available carbon source that can in principle be used for the synthesis of biomass/biofuels and value-added products. However, as synthetic chemistry lacks suitable catalysts to functionalize the CO2-molecule, there is an increasing need to exploit the CO2-fixing mechanisms offered by Nature for applications at the interface of chemistry and biology. This proposal is centered on reductive carboxylation, a completely novel principle of enzymatic CO2-fixation that we discovered only recently and that is one of the most efficient CO2-fixation reactions described in biology so far. First, we will focus on understanding the novel principle of reductive carboxylation, by studying its catalysis at molecular scale and single step resolution. This will allow us to derive the first detailed catalytic framework for highly efficient CO2-fixation and enable us to engineer novel carboxylation reactions and products. Second, we will establish a new in vitro platform for the assembly and optimization of artificial ('synthetic') CO2-fixation pathways that are based on reductive carboxylation and that have been calculated to be kinetically and bioenergetically favored compared with naturally existing CO2-fixation pathways. This platform closes a long-standing gap between the theory and practice of synthetic pathway design, and will be used to develop the first functional in vitro module for CO2-fixation, a 'synthetic organelle'. Finally, we will realize synthetic CO2-fixation in selected biological model systems. To that end, we will implement the optimized in vitro pathways in isolated chloroplasts, as well as alpha-proteobacterial hosts to create novel CO2-fixing organelles and organisms, breaking new grounds in understanding and engineering biological systems for efficient CO2-fixation.'
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Iria Bernhardsgrütter, Kristina Schell, Dominik M. Peter, Farshad Borjian, David Adrian Saez, Esteban Vöhringer-Martinez, Tobias J. Erb Awakening the Sleeping Carboxylase Function of Enzymes: Engineering the Natural CO 2 -Binding Potential of Reductases published pages: 9778-9782, ISSN: 0002-7863, DOI: 10.1021/jacs.9b03431 |
Journal of the American Chemical Society 141/25 | 2020-04-14 |
| 2019 |
Gabriele M. M. Stoffel, David Adrian Saez, Hasan DeMirci, Bastian Vögeli, Yashas Rao, Jan Zarzycki, Yasuo Yoshikuni, Soichi Wakatsuki, Esteban Vöhringer-Martinez, Tobias J. Erb Four amino acids define the CO 2 binding pocket of enoyl-CoA carboxylases/reductases published pages: 13964-13969, ISSN: 0027-8424, DOI: 10.1073/pnas.1901471116 |
Proceedings of the National Academy of Sciences 116/28 | 2020-04-14 |
| 2018 |
Simon Burgener, Thomas Schwander, Elvira Romero, Marco Fraaije, Tobias Erb Molecular Basis for Converting (2S)-Methylsuccinyl-CoA Dehydrogenase into an Oxidase published pages: 68, ISSN: 1420-3049, DOI: 10.3390/molecules23010068 |
Molecules 23/1 | 2020-04-14 |
| 2015 |
Dominik M. Peter, Lennart Schada von Borzyskowski, Patrick Kiefer, Philipp Christen, Julia A. Vorholt, Tobias J. Erb Screening and Engineering the Synthetic Potential of Carboxylating Reductases from Central Metabolism and Polyketide Biosynthesis published pages: 13457-13461, ISSN: 1433-7851, DOI: 10.1002/anie.201505282 |
Angewandte Chemie International Edition 54/45 | 2020-04-14 |
| 2018 |
Tobias J Erb, Jan Zarzycki A short history of RubisCO: the rise and fall (?) of Nature\'s predominant CO 2 fixing enzyme published pages: 100-107, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2017.07.017 |
Current Opinion in Biotechnology 49 | 2020-04-14 |
| 2018 |
Thomas Schwander, Richard McLean, Jan Zarzycki, Tobias J. Erb Structural basis for substrate specificity of methylsuccinyl-CoA dehydrogenase, an unusual member of the acyl-CoA dehydrogenase family published pages: 1702-1712, ISSN: 0021-9258, DOI: 10.1074/jbc.RA117.000764 |
Journal of Biological Chemistry 293/5 | 2020-04-14 |
| 2016 |
Thomas Schwander, Lennart Schada von Borzyskowski, Simon Burgener, Niña Socorro Cortina, Tobias J. Erb A synthetic pathway for the fixation of carbon dioxide in vitro published pages: 900-904, ISSN: 0036-8075, DOI: 10.1126/science.aah5237 |
Science 354/6314 | 2020-04-14 |
| 2016 |
Dominik Peter, Bastian Vögeli, Niña Cortina, Tobias Erb A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters published pages: 517, ISSN: 1420-3049, DOI: 10.3390/molecules21040517 |
Molecules 21/4 | 2020-04-14 |
| 2017 |
Johannes Döhlemann, Marcel Wagner, Carina Happel, Martina Carrillo, Patrick Sobetzko, Tobias J. Erb, Martin Thanbichler, Anke Becker A Family of Single Copy repABC -Type Shuttle Vectors Stably Maintained in the Alpha-Proteobacterium Sinorhizobium meliloti published pages: 968-984, ISSN: 2161-5063, DOI: 10.1021/acssynbio.6b00320 |
ACS Synthetic Biology 6/6 | 2020-04-14 |
| 2017 |
Raoul G Rosenthal, Bastian Vögeli, Tristan Wagner, Seigo Shima, Tobias J Erb A conserved threonine prevents self-intoxication of enoyl-thioester reductases published pages: 745-749, ISSN: 1552-4450, DOI: 10.1038/nchembio.2375 |
Nature Chemical Biology 13/7 | 2020-04-14 |
| 2016 |
Tobias J Erb, Jan Zarzycki Biochemical and synthetic biology approaches to improve photosynthetic CO2-fixation published pages: 72-79, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2016.06.026 |
Current Opinion in Chemical Biology 34 | 2020-04-14 |
| 2017 |
Tobias J Erb, Patrik R Jones, Arren Bar-Even Synthetic metabolism: metabolic engineering meets enzyme design published pages: 56-62, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2016.12.023 |
Current Opinion in Chemical Biology 37 | 2020-04-14 |
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