Explore the words cloud of the NEUROMITO project. It provides you a very rough idea of what is the project "NEUROMITO" about.
The following table provides information about the project.
Coordinator |
UNIVERSIDAD AUTONOMA DE BARCELONA
Organization address contact info |
Coordinator Country | Spain [ES] |
Project website | http://www.quintanalab.org/neuromito-elucidating-neuronal-susceptibility-to-mitochondrial-disease |
Total cost | 1˙500˙000 € |
EC max contribution | 1˙500˙000 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2014-STG |
Funding Scheme | ERC-STG |
Starting year | 2015 |
Duration (year-month-day) | from 2015-05-01 to 2020-04-30 |
Take a look of project's partnership.
# | ||||
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1 | UNIVERSIDAD AUTONOMA DE BARCELONA | ES (CERDANYOLA DEL VALLES) | coordinator | 1˙500˙000.00 |
Mitochondria generate most of the energy cells require to function. Deficits in the mitochondrial energy-generating machinery affect 1:5,000 children and cause progressive, debilitating, and usually fatal pathologies collectively known as primary mitochondrial disease. To date, there is no cure for mitochondrial disease and existing treatments are highly ineffective and mostly palliative. High-energy-requiring cells, such as neurons, are especially affected in mitochondrial disease. However, not all neuronal populations are equally affected. Furthermore, the molecular determinants of neuronal vulnerability to mitochondrial disease have not been adequately elucidated, representing a challenge for the development of efficient treatments for these pathologies. To improve on current knowledge on mitochondrial disease and to provide better therapeutic targets, this project focuses on developing ground-breaking mouse genetics and molecular biology tools that will allow the identification and dissection of the molecular determinants of neuronal vulnerability in mitochondrial disease with unprecedented definition. We will develop novel techniques to isolate both the mitochondrial and cytosolic translatome by using ribosomal tagging in vivo as well as to assess intact mitochondrial function with cell-type specificity and temporal resolution. These novel approaches will have a high impact in mitochondrial disease, with the overall aim of identifying novel therapeutic targets that will lead to effective treatments for mitochondrial disease. Furthermore, the high applicability of the tools generated will allow significant breakthroughs in the research of other pathologies with mitochondrial affectation such as diabetes or neurodegenerative processes.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Elisenda Sanz, Jonathan C. Bean, Daniel P. Carey, Albert Quintana, G. Stanley McKnight RiboTag: Ribosomal Tagging Strategy to Analyze Cell-Type-Specific mRNA Expression In Vivo published pages: e77, ISSN: 1934-8584, DOI: 10.1002/cpns.77 |
Current Protocols in Neuroscience 88/1 | 2020-01-29 |
2019 |
Irene Bolea, Alejandro Gella, Elisenda Sanz, Patricia Prada-Dacasa, Fabien Menardy, Angela M Bard, Pablo Machuca-Márquez, Abel Eraso-Pichot, Guillem Mòdol-Caballero, Xavier Navarro, Franck Kalume, Albert Quintana Defined neuronal populations drive fatal phenotype in a mouse model of Leigh Syndrome published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.47163 |
eLife 8 | 2020-01-29 |
2016 |
Pavel I. Zimin, Christian B. Woods, Albert Quintana, Jan-Marino Ramirez, Philip G. Morgan, Margaret M. Sedensky Glutamatergic Neurotransmission Links Sensitivity to Volatile Anesthetics with Mitochondrial Function published pages: 2194-2201, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.06.020 |
Current Biology 26/16 | 2020-01-29 |
2017 |
Byron Chen, Jessica Hui, Kelsey S. Montgomery, Alejandro Gella, Irene Bolea, Elisenda Sanz, Richard D. Palmiter, Albert Quintana Loss of Mitochondrial Ndufs4 in Striatal Medium Spiny Neurons Mediates Progressive Motor Impairment in a Mouse Model of Leigh Syndrome published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2017.00265 |
Frontiers in Molecular Neuroscience 10 | 2020-01-29 |
2017 |
Aundrea Rainwater, Elisenda Sanz, Richard D. Palmiter, Albert Quintana Striatal GPR88 Modulates Foraging Efficiency published pages: 7939-7947, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.2439-16.2017 |
The Journal of Neuroscience 37/33 | 2020-01-29 |
2016 |
Stephanie L Padilla, Jian Qiu, Marta E Soden, Elisenda Sanz, Casey C Nestor, Forrest D Barker, Albert Quintana, Larry S Zweifel, Oline K Rønnekleiv, Martin J Kelly, Richard D Palmiter Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state published pages: 734-741, ISSN: 1097-6256, DOI: 10.1038/nn.4274 |
Nature Neuroscience 19/5 | 2020-01-29 |
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The information about "NEUROMITO" are provided by the European Opendata Portal: CORDIS opendata.
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