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A CACTUS

Antibody-free method for Counting All Circulating TUmour cellS while maintaining them alive and intact

Total Cost €

0

EC-Contrib. €

0

Partnership

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 A CACTUS project word cloud

Explore the words cloud of the A CACTUS project. It provides you a very rough idea of what is the project "A CACTUS" about.

count    enter    critical    aerobic    diagnostic    pico    proof    glycolysis    stream    attractive    cells    lung    blood    circulating    dyes    obvious    oil    detected    showed    characterising    fluidic    counting    responsible    isolate    display    effect    fda    proposition    sites    business    emulsions    idea    investors    portfolio    breast    patient    sorting    enzymatic    ph    proper    strategy    provides    assays    detecting    surrounding    ip    micro    deaths    lactate    water    bladder    commercialisation    maintaining    cellsearch    liter    microenvironment    cytosol    ctc    progression    instead    influence    outcome    tumour    rate    metabolic    consisting    detects    warburg    intact    meant    cactus    colon    environmental    metastatic    prostate    treatment    induce    gastric    sensitive    90    alive    detection    plan    presented    mesenchymal    labelling    inexpensive    probing    volume    commercialising    ctcs    correctly    metastases    separating    feasibility    droplets    cancer    epithelial    approved    veridex    antibody    final   

Project "A CACTUS" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITA DEGLI STUDI DI UDINE 

Organization address
address: VIA PALLADIO 8
city: UDINE
postcode: 33100
website: www.uniud.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Total cost 149˙875 €
 EC max contribution 149˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2016-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI UDINE IT (UDINE) coordinator 149˙875.00

Map

 Project objective

The problem: Cancer metastases are responsible for 90% of cancer-associated deaths. Circulating tumour cells (CTCs) that enter the blood stream on their way to potential metastatic sites are of obvious interest to evaluate correctly patient treatment and therefore influence outcome. CTCs have been identified in bladder, gastric, prostate, lung, breast and colon cancer. The only FDA approved CTCs detection system is Veridex’ CellSearch, which detects only epithelial cancer cells using antibody labelling. Recent evidence showed that non-epithelial cancer cells, which are not detected by CellSearch, are of critical importance in cancer progression.

The idea: Our CTC detection method is based, instead of on antibody labelling, on metabolic features of cancer cells, thus providing potential for detecting both epithelial and mesenchymal cancer cells. Cancer cells induce environmental changes; e.g. in aerobic conditions most cancer cells display a high rate of glycolysis with lactate production in the cytosol, known as the Warburg effect. By separating cells into micro-droplets of pico-liter volume using micro-fluidic water-in-oil emulsions and by characterising the microenvironment surrounding them, CTCs are detected by probing for environmental changes using pH sensitive dyes or enzymatic lactate assays. Our inexpensive diagnostic method provides a way to count and isolate CTCs without any labelling while maintaining cells alive and intact for further studies.

The project: “A CACTUS” is meant to assess the feasibility of commercialising the developed method for counting and sorting CTCs and develop a proper commercialisation strategy. The final goal of this project is to develop a proposition package consisting of technical proof of concept, the business proposition and strategy and an IP portfolio and strategy. This information will be presented in an attractive business plan that will be proposed to potential investors.

 Publications

year authors and title journal last update
List of publications.
2016 Fabio Del Ben, Matteo Turetta, Giorgia Celetti, Aigars Piruska, Michela Bulfoni, Daniela Cesselli, Wilhelm T. S. Huck, Giacinto Scoles
A Method for Detecting Circulating Tumor Cells Based on the Measurement of Single-Cell Metabolism in Droplet-Based Microfluidics
published pages: 8581-8584, ISSN: 1433-7851, DOI: 10.1002/anie.201602328 		Angewandte Chemie International Edition 55/30 2019-07-23

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