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TOLLerant SIGNED

Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach.

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

TOLLerant project word cloud

Explore the words cloud of the TOLLerant project. It provides you a very rough idea of what is the project "TOLLerant" about.

treatment adjuvants entrepreneurial pharmacological motivate mindset biophysics treat chemistry relying therapeutic info 2014 senior modern competences broad cultural pathologies chemical cultivate sepsis employability biology agonists pharmacology stage disorders training committed cns create scientists components antagonists impressively chronic mainly edge infectious inflammation young cutting disciplinary inflammatory international activation bm1003 acute cd14 md autoimmune synergies agents team gain based lacking trl4 company compounds interact therapeutics innovative immunity private animal expertise selectively mechanisms diseases modulators academic lack skills recognition synthetic allergy esrs start toxic tlr4 companies 2011 action asthma efficient anti models natural entrepreneurship scientific spectrum inter vaccine day generation molecular cancer esr tollerant interactions innate inflammations consolidated combination signaling nanoparticles group biochemistry allergies

Project "TOLLerant" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA Organization address address: PIAZZA DELL'ATENEO NUOVO 1 city: MILANO postcode: 20126 website: www.unimib.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.tollerant.eu
Total cost	3˙122˙539 €
EC max contribution	3˙122˙539 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA Organization address address: PIAZZA DELL'ATENEO NUOVO 1 city: MILANO postcode: 20126 website: www.unimib.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	coordinator	516˙122.00
2	UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Organization address address: CORSO UMBERTO I, 40 city: NAPOLI postcode: 80138 website: www.unina.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (NAPOLI)	participant	516˙122.00
3	KEMIJSKI INSTITUT KEMIJSKI INSTITUT Organization address address: HAJDRIHOVA 19 city: LJUBLJANA postcode: 1000 website: http://www.ki.si contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SI (LJUBLJANA)	participant	469˙995.00
4	VIB VIB Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE - GENT)	participant	250˙560.00
5	UNIVERSITAET BIELEFELD UNIVERSITAET BIELEFELD Organization address address: UNIVERSITAETSSTRASSE 25 city: BIELEFELD postcode: 33615 website: www.uni-bielefeld.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BIELEFELD)	participant	249˙216.00
6	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	247˙872.00
7	ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS Organization address address: PARQUE TECNOLOGICO EDIFICIO 801 A city: DERIO VIZCAYA postcode: 48160 website: www.cicbiogune.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (DERIO VIZCAYA)	participant	247˙872.00
8	ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE Organization address address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C city: SAN SEBASTIAN postcode: 20009 website: www.cicbiomagune.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SAN SEBASTIAN)	participant	247˙872.00
9	DIOMUNE SL DIOMUNE SL Organization address address: CL FELIX BOIX 9 4 C city: MADRID postcode: 28036 website: www.diomune.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	247˙872.00
10	LOFARMA S.P.A. LOFARMA S.P.A. Organization address address: VIALE CASSALA, 40 city: MILAN postcode: 20143 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILAN)	participant	129˙030.00

Map

Project objective

Based on an international team derived from the COST action BM1003 (www.cost-bm1003.info, 2011-2014) and thus relying on consolidated group interactions and synergies and on a unique combination of chemistry, biology, biophysics, biochemistry and pharmacology expertise, the TOLLerant project aims to gain information on molecular aspects of TLR4 activation and signaling by using synthetic and natural compounds and nanoparticles that interact selectively with some components (mainly MD-2 and CD14) of the TRL4 recognition system. TLR4 is an emerging molecular target related to an impressively broad spectrum of modern day disorders still lacking specific pharmacological treatment. These include autoimmune disorders, chronic inflammations, allergies, asthma, infectious and CNS diseases and cancer. The short-term scientific objective is to develop novel, non-toxic, synthetic and natural TLR4 modulators (agonists or antagonists) and to assess their therapeutic potential on animal models of TLR4-related acute and chronic pathologies that still lack efficient pharmacological treatment. The long-term scientific objective is to develop a new generation of innovative, TLR4-based therapeutics, to be used as vaccine adjuvants, anti-sepsis agents, and anti-inflammatory agents to treat chronic inflammations (allergy, asthma). The training programme will provide Early Stage Researchers (ESR) with broad competences, experience and skills in the cutting-edge, inter-disciplinary research in the field of chemical biology related to the molecular mechanisms of innate immunity and inflammation. During the training, the young researchers will be supported by senior scientists to cultivate their scientific, entrepreneurial and inter-cultural mindset. The non-academic sector will be committed to provide ESRs with entrepreneurship and company management skills, in order to enhance their employability by the private sector or even to motivate them to create own start-up companies.

Deliverables

List of deliverables.
Agenda	Documents, reports	2019-07-22 08:10:45
TOLLerant website	Websites, patent fillings, videos etc.	2019-05-22 20:37:28
Annual agenda of outreach activities	Documents, reports	2019-07-22 08:10:53
Progress, periodic, midterm and final reports	Documents, reports	2019-07-22 08:10:46
Minutes of training events	Documents, reports	2019-07-22 08:10:45
TOLLerant linkedIn group	Websites, patent fillings, videos etc.	2019-05-22 20:37:28
Consortium quarterly newsletter	Documents, reports	2019-07-22 08:10:51
Training reports	Documents, reports	2019-07-22 08:10:48
Protocols for molecular modelling	Demonstrators, pilots, prototypes	2019-05-22 20:37:28
Dissemination plan	Documents, reports	2019-05-22 20:37:29

Take a look to the deliverables list in detail: detailed list of TOLLerant deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Florent Cochet, Francesco Peri The Role of Carbohydrates in the Lipopolysaccharide (LPS)/Toll-Like Receptor 4 (TLR4) Signalling published pages: 2318, ISSN: 1422-0067, DOI: 10.3390/ijms18112318	International Journal of Molecular Sciences 18/11	2019-06-05
2017	Flaviana Diâ€…Lorenzo, Angelo Palmigiano, Katarzyna A. Duda, Mateusz Pallach, Nicolas Busset, Luisa Sturiale, Eric Giraud, Domenico Garozzo, Antonio Molinaro, Alba Silipo Structure of the Lipopolysaccharide from the Bradyrhizobium sp. ORS285 rfaL Mutant Strain published pages: 541-553, ISSN: 2191-1363, DOI: 10.1002/open.201700074	ChemistryOpen 6/4	2019-06-05
2018	Clara Barrau, Flaviana Di Lorenzo, Rodolfo Menes, Rosa Lanzetta, Antonio Molinaro, Alba Silipo The Structure of the Lipid A from the Halophilic Bacterium Spiribacter salinus M19-40T published pages: 124, ISSN: 1660-3397, DOI: 10.3390/md16040124	Marine Drugs 16/4	2019-06-05
2017	Flaviana Di Lorenzo, Angelo Palmigiano, Ida Paciello, Mateusz Pallach, Domenico Garozzo, Maria-Lina Bernardini, Violetta La Cono, Michail M. Yakimov, Antonio Molinaro, Alba Silipo The Deep-Sea Polyextremophile Halobacteroides lacunaris TB21 Rough-Type LPS: Structure and Inhibitory Activity towards Toxic LPS published pages: 201, ISSN: 1660-3397, DOI: 10.3390/md15070201	Marine Drugs 15/12	2019-06-05
2018	Fabio A. Facchini, Lenny Zaffaroni, Alberto Minotti, Silvia Rapisarda, Valentina Calabrese, Matilde Forcella, Paola Fusi, Cristina Airoldi, Carlotta Ciaramelli, Jean-Marc Billod, Andra B. Schromm, Harald Braun, Charys Palmer, Rudi Beyaert, Fabio Lapenta, Roman Jerala, Grisha Pirianov, Sonsoles Martin-Santamaria, Francesco Peri Structureâ€“Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists published pages: , ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b01803	Journal of Medicinal Chemistry	2019-06-05
2018	Flaviana Di Lorenzo, Angelo Palmigiano, Sami Albitar-Nehme, Mateusz Pallach, Maxim Kokoulin, Nadezhda Komandrova, Lyudmila Romanenko, Maria Lina Bernardini, Domenico Garozzo, Antonio Molinaro, Alba Silipo Lipid A Structure and Immunoinhibitory Effect of the Marine Bacterium Cobetia pacifica KMM 3879 T published pages: 2707-2716, ISSN: 1434-193X, DOI: 10.1002/ejoc.201800279	European Journal of Organic Chemistry 2018/20-21	2019-06-05
2018	Fabio A. Facchini, Helena Coelho, Stefania E. Sestito, Sandra Delgado, Alberto Minotti, David Andreu, JesÃºs JimÃ©nez-Barbero, Francesco Peri Co-administration of Antimicrobial Peptides Enhances Toll-like Receptorâ€…4 Antagonist Activity of a Synthetic Glycolipid published pages: 280-287, ISSN: 1860-7179, DOI: 10.1002/cmdc.201700694	ChemMedChem 13/3	2019-06-05
2018	Lenny Zaffaroni, Francesco Peri Recent advances on Toll-like receptor 4Â modulation: new therapeutic perspectives published pages: , ISSN: 1756-8919, DOI: 10.4155/fmc-2017-0172	Future Medicinal Chemistry	2019-06-05
2019	Giordano Traini, Ane Ruiz-de-Angulo, Juan Bautista Blanco-Canosa, Kepa Zamacola BascarÃ¡n, Antonio Molinaro, Alba Silipo, David Escors, Juan C. Mareque-Rivas Cancer Immunotherapy of TLR4 Agonist-Antigen Constructs Enhanced with Pathogen-Mimicking Magnetite Nanoparticles and Checkpoint Blockade of PD-L1 published pages: 1803993, ISSN: 1613-6810, DOI: 10.1002/smll.201803993	Small 15/4	2019-06-03
2017	Matilde de las Rivas, Erandi Lira-Navarrete, Earnest James Paul Daniel, Ismael CompaÃ±Ã³n, Helena Coelho, Ana Diniz, JesÃºs JimÃ©nez-Barbero, JesÃºs M. Peregrina, Henrik Clausen, Francisco Corzana, Filipa Marcelo, Gonzalo JimÃ©nez-OsÃ©s, Thomas A. Gerken, Ramon Hurtado-Guerrero The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02006-0	Nature Communications 8/1	2019-05-22
2019	Giordano Traini, Ane Ruiz-de-Angulo, Juan Bautista Blanco-Canosa, Kepa Zamacola BascarÃ¡n, Antonio Molinaro, Alba Silipo, David Escors, Juan C. Mareque-Rivas Cancer Immunotherapy of TLR4 Agonist-Antigen Constructs Enhanced with Pathogen-Mimicking Magnetite Nanoparticles and Checkpoint Blockade of PD-L1 published pages: 1803993, ISSN: 1613-6810, DOI: 10.1002/smll.201803993	Small 15/4	2019-05-22
2018	Luigi Lembo-Fazio, Jean-Marc Billod, Flaviana Di Lorenzo, Ida Paciello, Mateusz Pallach, Sara Vaz-Francisco, Aurora Holgado, Rudi Beyaert, Manuel Fresno, Atsushi Shimoyama, Rosa Lanzetta, Koichi Fukase, Djamel Gully, Eric Giraud, Sonsoles MartÃn-SantamarÃa, Maria-Lina Bernardini, Alba Silipo Bradyrhizobium Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01888	Frontiers in Immunology 9	2019-05-22
2018	Fabio Lapenta, Jana AupiÄ, Å½iga StrmÅ¡ek, Roman Jerala Coiled coil protein origami: from modular design principles towards biotechnological applications published pages: 3530-3542, ISSN: 0306-0012, DOI: 10.1039/c7cs00822h	Chemical Society Reviews 47/10	2019-05-22
2017	Ajasja LjubetiÄ, Fabio Lapenta, Helena GradiÅ¡ar, Igor Drobnak, Jana AupiÄ, Å½iga StrmÅ¡ek, DuÅ¡ko LainÅ¡Äek, Iva Hafner-BratkoviÄ, Andreja Majerle, NuÅ¡a Krivec, Mojca BenÄina, TomaÅ¾ Pisanski, Tanja Ä†irkoviÄ‡ VeliÄkoviÄ‡, Adam Round, JosÃ© MarÃa Carazo, Roberto Melero, Roman Jerala Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo published pages: , ISSN: 1087-0156, DOI: 10.1038/nbt.3994	Nature Biotechnology	2019-05-22
2018	Mateusz Pallach, Flaviana Di Lorenzo, Fabio Alessandro Facchini, Djamel Gully, Eric Giraud, Francesco Peri, Katarzyna A. Duda, Antonio Molinaro, Alba Silipo Structure and inflammatory activity of the LPS isolated from Acetobacter pasteurianus CIP103108 published pages: 1027-1035, ISSN: 0141-8130, DOI: 10.1016/j.ijbiomac.2018.08.035	International Journal of Biological Macromolecules 119	2019-05-22
2019	Florent Cochet, Fabio A. Facchini, Lenny Zaffaroni, Jean-Marc Billod, Helena Coelho, Aurora Holgado, Harald Braun, Rudi Beyaert, Roman Jerala, Jesus Jimenez-Barbero, Sonsoles Martin-Santamaria, Francesco Peri Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37421-w	Scientific Reports 9/1	2019-05-22
2016	Beatriz Salvador, Alicia Arranz, Sara Francisco, Laura CÃ³rdoba, Carmen PunzÃ³n, Miguel Ãngel Llamas, Manuel Fresno Modulation of endothelial function by Toll like receptors published pages: 46-56, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2016.03.038	Pharmacological Research 108	2019-06-05
2016	Jean-Marc Billod, Alessandra Lacetera, Joan GuzmÃ¡n-Caldentey, Sonsoles MartÃn-SantamarÃa Computational Approaches to Toll-Like Receptor 4 Modulation published pages: 994, ISSN: 1420-3049, DOI: 10.3390/molecules21080994	Molecules 21/8	2019-06-05

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The information about "TOLLERANT" are provided by the European Opendata Portal: CORDIS opendata.

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