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eCHO Systems

Enhancing CHO by Mammalian Systems Biotechnology (eCHO systems)

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

eCHO Systems project word cloud

Explore the words cloud of the eCHO Systems project. It provides you a very rough idea of what is the project "eCHO Systems" about.

flexibility esr industrial graduates dates training hamster biopharmaceutical sequencing billion consideration productivity cadre chassises machinery incorporation courses omics significantly data universities cytometry breadth entrepreneurship education performance mathematical cellular acquisition poised interdisciplinary ovary synthetic opportunity itn optimisation benefit host modeling transform cell media conventional genome little quality computational 1980 biological outputs line graduate skills intense molecular market biology 15 tools producers participate blend models fortunately platform primarily engineering technologies lines echo platforms complementary biotechnology cho biopharmaceuticals business cells opened lower chinese optimization network efficiency

Project "eCHO Systems" data sheet

The following table provides information about the project.

Coordinator	DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://www.echo-systems.eu
Total cost	4˙044˙794 €
EC max contribution	4˙044˙793 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	coordinator	1˙160˙327.00
2	ACIB GMBH ACIB GMBH Organization address address: KRENNGASSE 37/2 city: GRAZ postcode: 8010 website: www.acib.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (GRAZ)	participant	1˙017˙018.00
3	UNIVERSITY OF KENT UNIVERSITY OF KENT Organization address address: THE REGISTRY CANTERBURY city: CANTERBURY, KENT postcode: CT2 7NZ website: www.kent.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CANTERBURY, KENT)	participant	819˙863.00
4	DUBLIN CITY UNIVERSITY DUBLIN CITY UNIVERSITY Organization address address: Glasnevin city: DUBLIN postcode: 9 website: www.dcu.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	797˙023.00
5	UCB PHARMA SA UCB PHARMA SA Organization address address: ALLEE DE LA RECHERCHE 60 city: BRUXELLES postcode: 1070 website: www.ucb.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	250˙560.00
6	RENTSCHLER BIOTECHNOLOGIE GMBH RENTSCHLER BIOTECHNOLOGIE GMBH Organization address address: ERWIN RENTSCHLER STRASSE 21 city: LAUPHEIM postcode: 88471 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LAUPHEIM)	participant	0.00
7	BIONEER A/S BIONEER A/S Organization address address: KOGLE ALLE 2 city: HOERSHOLM postcode: 2970 website: www.bioneer.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HOERSHOLM)	partner	0.00
8	BOEHRINGER INGELHEIM PHARMA GMBH &CO KG BOEHRINGER INGELHEIM PHARMA GMBH &CO KG Organization address address: BINGER STRASSE 173 city: INGELHEIM postcode: 55218 website: www.boehringer-ingelheim.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (INGELHEIM)	partner	0.00
9	Chorus GmbH Chorus GmbH Organization address address: UNTERGRAFENDORF 17 city: BOHEIMKIRCHEN postcode: 3071 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (BOHEIMKIRCHEN)	partner	0.00
10	CMC BIOLOGICS AS CMC BIOLOGICS AS Organization address address: Vandtaarnsvej 83 B city: SOBORG postcode: 2860 website: www.cmc-biologics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (SOBORG)	partner	0.00
11	Eli Lilly and Company Limited Eli Lilly and Company Limited Organization address address: Lilly House, Priestley Road city: Basingstoke postcode: RG24 9NL website: www.lilly.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Basingstoke)	partner	0.00
12	EVERCYTE GMBH EVERCYTE GMBH Organization address address: MUTHGASSE 18 city: WIEN postcode: 1190 website: www.evercyte.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	partner	0.00
13	FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED Organization address address: BELASIS AVENUE city: BILLINGHAM postcode: TS23 1LH website: www.fujifilmdiosynth.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BILLINGHAM)	partner	0.00
14	ICOSAGEN AS ICOSAGEN AS Organization address address: NOORUSE 9 city: TARTU postcode: 50411 website: www.icosagen.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TARTU)	partner	0.00
15	Janssen Biologics Janssen Biologics Organization address address: Einsteinweg 101 city: Leiden postcode: 2300AG website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Leiden)	partner	0.00
16	Symphogen A/S Symphogen A/S Organization address address: Elektrovej Byg. 375 city: Lyngby postcode: 2800 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (Lyngby)	partner	0.00
17	UNIVERSITAET FUER BODENKULTUR WIEN UNIVERSITAET FUER BODENKULTUR WIEN Organization address address: GREGOR MENDEL STRASSE 33 city: WIEN postcode: 1180 website: www.boku.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	partner	0.00

Map

Project objective

Chinese hamster (CHO) ovary cells are the production host for a 50 billion €/yr biopharmaceuticals market. Current CHO production platforms dates to 1980 and are based primarily on media and process optimisation with little consideration to the optimization of the cellular machinery. Fortunately, with the recent sequencing of the CHO genome, an opportunity has opened to significantly advance the CHO platform. The benefit will be advanced production flexibility and a lower production cost.

This ITN graduate training programme - eCHO Systems - will blend conventional molecular, cellular, and synthetic biology with genome scale systems biology training in ‘omics data acquisition, biological network modeling, and genome engineering in three interdisciplinary topics:

1) Acquisition of large scale ‘omics data sets and their incorporation into genome-scale mathematical models 2) Development of genome engineering tools, enabling synthetic biology 3) Application of systems and synthetic biology and genome engineering to improve performance of CHO producers

The training projects are supported by 15 industrial participants, which will participate in the research and test the results. ESR training will include intense courses focused on computational systems biology, cell biology, business and entrepreneurship. The three universities bring unique complementary skills in systems and synthetic biology, ‘omics technologies, cytometry, and molecular cell biology which will provide depth and breadth to this training. The eCHO Systems will produce four major outputs: General knowledge to improve the productivity, quality, and efficiency of CHO platform cell lines, new systems models for CHO cells, new CHO cell line chassises generated through synthetic biology approaches, high quality education at the graduate level, and a cadre of interdisciplinary graduates poised to transform biopharmaceutical biotechnology.

Deliverables

List of deliverables.
Integration of proteomic and post-translational data	Documents, reports	2019-09-06 08:37:52
Omics-datasets distributed	Documents, reports	2019-09-06 08:37:52
Publications	Documents, reports	2019-09-06 08:37:52
High throughput screens for gene function and engineered CHO chassis designed for improved recombinant protein yields	Documents, reports	2019-09-06 08:37:52
Transcriptional and genomic cross-effects	Documents, reports	2019-09-06 08:37:52
Training complete	Other	2019-09-06 08:37:52
Effects of lncRNAs	Documents, reports	2019-09-06 08:37:52
Final Report	Documents, reports	2019-09-06 08:37:52
Enhancing translational rates and protein synthesis	Documents, reports	2019-09-06 08:37:52
Mid Term review meeting	Documents, reports	2019-09-06 08:37:52
Appointment of SAB	Other	2019-09-06 08:37:51

Take a look to the deliverables list in detail: detailed list of eCHO Systems deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Heena Dhiman, Matthias P. Gerstl, David Ruckerbauer, Michael Hanscho, Heinz Himmelbauer, Colin Clarke, Niall Barron, JÃ¼rgen Zanghellini, Nicole Borth Genetic and epigenetic variation across genes involved in energy metabolism and mitochondria of Chinese Hamster Ovary cell lines published pages: 1800681, ISSN: 1860-6768, DOI: 10.1002/biot.201800681	Biotechnology Journal	2019-09-06
2017	Henning Gram Hansen, NuÅ¡a PristovÅ¡ek, Helene Faustrup Kildegaard, Gyun Min Lee Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions published pages: 64-76, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2016.11.008	Biotechnology Advances 35/1	2019-09-06
2018	Linas TamoÅ¡aitis, Christopher Mark Smales Meta-Analysis of Publicly Available Chinese Hamster Ovary (CHO) Cell Transcriptomic Datasets for Identifying Engineering Targets to Enhance Recombinant Protein Yields published pages: 1800066, ISSN: 1860-6768, DOI: 10.1002/biot.201800066	Biotechnology Journal	2019-09-06
2018	Prashant Kaushik, Michael Henry, Martin Clynes, Paula Meleady The Expression Pattern of the Phosphoproteome Is Significantly Changed During the Growth Phases of Recombinant CHO Cell Culture published pages: 1700221, ISSN: 1860-6768, DOI: 10.1002/biot.201700221	Biotechnology Journal 13/10	2019-09-06
2018	Nina Bydlinski, Daniel Maresch, Valerie Schmieder, Gerald Klanert, Richard Strasser, Nicole Borth The contributions of individual galactosyltransferases to protein specific N-glycan processing in Chinese Hamster Ovary cells published pages: 101-110, ISSN: 0168-1656, DOI: 10.1016/j.jbiotec.2018.07.015	Journal of Biotechnology 282	2019-09-06
2019	Cyrielle Calmels, AndrÃ©a McCann, Laetitia Malphettes, Mikael RÃ¸rdam Andersen Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process published pages: 9-19, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2018.09.009	Metabolic Engineering 51	2019-09-06
2018	Davide Vito, C Mark Smales Engineering of the cellular translational machinery and non-coding RNAs to enhance CHO cell growth, recombinant product yields and quality published pages: 199-208, ISSN: 2211-3398, DOI: 10.1016/j.coche.2018.11.002	Current Opinion in Chemical Engineering 22	2019-09-06
2017	Michael Henry, Martin Power, Prashant Kaushik, Orla Coleman, Martin Clynes, Paula Meleady Differential Phosphoproteomic Analysis of Recombinant Chinese Hamster Ovary Cells Following Temperature Shift published pages: 2339-2358, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.6b00868	Journal of Proteome Research 16/7	2019-09-06
2019	Thomas Amann, Anders Holmgaard Hansen, Stefan Kol, Henning Gram Hansen, Johnny Arnsdorf, Saranya Nallapareddy, BjÃ¸rn Voldborg, Gyun Min Lee, Mikael RÃ¸rdam Andersen, Helene Faustrup Kildegaard Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles published pages: 143-152, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2018.11.014	Metabolic Engineering 52	2019-09-06
2019	Inmaculada Hernandez, Heena Dhiman, Gerald Klanert, Vaibhav Jadhav, Norbert Auer, Michael Hanscho, Martina Baumann, Anna Esteve-Codina, Marc Dabad, Jessica GÃ³mez, Tyler Alioto, Angelika Merkel, Emanuele Raineri, Simon Heath, Daniel Rico, Nicole Borth Epigenetic regulation of gene expression in Chinese Hamster Ovary cells in response to the changing environment of a batch culture published pages: 677-692, ISSN: 0006-3592, DOI: 10.1002/bit.26891	Biotechnology and Bioengineering 116/3	2019-09-06
2017	Paul S. Kelly, Colin Clarke, Alan Costello, Craig Monger, Justine Meiller, Heena Dhiman, Nicole Borth, Michael J. Betenbaugh, Martin Clynes, Niall Barron Ultra-deep next generation mitochondrial genome sequencing reveals widespread heteroplasmy in Chinese hamster ovary cells published pages: , ISSN: 1096-7176, DOI: 10.1016/j.ymben.2017.02.001	Metabolic Engineering	2019-09-06
2017	Amandine Bastide, Diego Peretti, John R.P. Knight, Stefano Grosso, Ruth V. Spriggs, Xavier Pichon, Thomas Sbarrato, Anne Roobol, Jo Roobol, Davide Vito, Martin Bushell, Tobias von der Haar, C. Mark Smales, Giovanna R. Mallucci, Anne E. Willis RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3 published pages: , ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.01.047	Current Biology	2019-09-06
2018	Thomas Amann, Anders Holmgaard Hansen, Stefan Kol, Gyun Min Lee, Mikael RÃ¸rdam Andersen, Helene Faustrup Kildegaard CRISPR/Cas9-multiplexed editing of Chinese hamster ovary B4Gal-T1, 2, 3 and 4 tailors N-glycan profiles of therapeutics and secreted host cell proteins published pages: 1800111, ISSN: 1860-6768, DOI: 10.1002/biot.201800111	Biotechnology Journal	2019-09-06
2018	Sara Pereira, Helene Faustrup Kildegaard, Mikael RÃ¸rdam Andersen Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients published pages: 1700499, ISSN: 1860-6768, DOI: 10.1002/biot.201700499	Biotechnology Journal 13/3	2019-09-06
2018	Valerie Schmieder, Nina Bydlinski, Richard Strasser, Martina Baumann, Helene Faustrup Kildegaard, Vaibhav Jadhav, Nicole Borth Enhanced Genome Editing Tools For Multi-Gene Deletion Knock-Out Approaches Using Paired CRISPR sgRNAs in CHO Cells published pages: 1700211, ISSN: 1860-6768, DOI: 10.1002/biot.201700211	Biotechnology Journal 13/3	2019-09-06
2018	NuÅ¡a PristovÅ¡ek, Henning Gram Hansen, Daria Sergeeva, Nicole Borth, Gyun Min Lee, Mikael RÃ¸rdam Andersen, Helene Faustrup Kildegaard Using Titer and Titer Normalized to Confluence Are Complementary Strategies for Obtaining Chinese Hamster Ovary Cell Lines with High Volumetric Productivity of Etanercept published pages: 1700216, ISSN: 1860-6768, DOI: 10.1002/biot.201700216	Biotechnology Journal 13/3	2019-09-06
2018	Oliver Rupp, Madolyn L. MacDonald, Shangzhong Li, Heena Dhiman, Shawn Polson, Sven Griep, Kelley Heffner, Inmaculada Hernandez, Karina Brinkrolf, Vaibhav Jadhav, Mojtaba Samoudi, Haiping Hao, Brewster Kingham, Alexander Goesmann, Michael J. Betenbaugh, Nathan E. Lewis, Nicole Borth, Kelvin H. Lee A reference genome of the Chinese hamster based on a hybrid assembly strategy published pages: , ISSN: 0006-3592, DOI: 10.1002/bit.26722	Biotechnology and Bioengineering	2019-09-06
2018	Ricardo ValdÃ©s-Bango Curell, Niall Barron Exploring the Potential Application of Short Non-Coding RNA-Based Genetic Circuits in Chinese Hamster Ovary Cells published pages: 1700220, ISSN: 1860-6768, DOI: 10.1002/biot.201700220	Biotechnology Journal	2019-09-06
2018	Davide Vito, Christopher Mark Smales The Long Non-Coding RNA Transcriptome Landscape in CHO Cells Under Batch and Fed-Batch Conditions published pages: 1800122, ISSN: 1860-6768, DOI: 10.1002/biot.201800122	Biotechnology Journal	2019-09-06
2018	Ankita Singh, Helene F. Kildegaard, Mikael R. Andersen An Online Compendium of CHO RNA-Seq Data Allows Identification of CHO Cell Line-specific Transcriptomic Signatures published pages: 1800070, ISSN: 1860-6768, DOI: 10.1002/biot.201800070	Biotechnology Journal	2019-09-06
2018	Nicolas Marx, Clemens GrÃ¼nwald-Gruber, Nina Bydlinski, Heena Dhiman, Ly Ngoc Nguyen, Gerald Klanert, Nicole Borth CRISPR-Based Targeted Epigenetic Editing Enables Gene Expression Modulation of the Silenced Beta-Galactoside Alpha-2,6-Sialyltransferase 1 in CHO Cells published pages: 1700217, ISSN: 1860-6768, DOI: 10.1002/biot.201700217	Biotechnology Journal	2019-09-06

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The information about "ECHO SYSTEMS" are provided by the European Opendata Portal: CORDIS opendata.