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IMMUNOSHAPE

Development of Selective Carbohydrate Immunomodulators Targeting C-type Lectin Receptors on Antigen Presenting Cells

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

IMMUNOSHAPE project word cloud

Explore the words cloud of the IMMUNOSHAPE project. It provides you a very rough idea of what is the project "IMMUNOSHAPE" about.

tumour screening chemistry active immunology structural microarray glycan biomedical combining selective immunotherapy device synthesis allergy medicinal training combination multisectorial esrs glycobiology practical talent immunoshape diseases cancer industrial solid carbohydrate 15 scientific highthroughput perspectives multivalent automated scientists structures academic young instrumentation sectors educate generation glycoscience autoimmune groups nanomedicine immunotherapeutics career final expertise multidisciplinary environment treatment fabrication innovation

Project "IMMUNOSHAPE" data sheet

The following table provides information about the project.

Coordinator	ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE Organization address address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C city: SAN SEBASTIAN postcode: 20009 website: www.cicbiomagune.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.immunoshape.eu/
Total cost	3˙811˙581 €
EC max contribution	3˙811˙581 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE Organization address address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C city: SAN SEBASTIAN postcode: 20009 website: www.cicbiomagune.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SAN SEBASTIAN)	coordinator	495˙745.00
2	THE UNIVERSITY OF MANCHESTER THE UNIVERSITY OF MANCHESTER Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL website: www.manchester.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	participant	273˙287.00
3	GLYCODIAG GLYCODIAG Organization address address: 520 RUE DU CHANTELOUP city: CHEVILLY postcode: 45520 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (CHEVILLY)	participant	262˙875.00
4	UNIVERSITE GRENOBLE ALPES UNIVERSITE GRENOBLE ALPES Organization address address: 621, AVENUE CENTRALE city: SAINT MARTIN D'HERES postcode: 38401 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SAINT MARTIN D'HERES)	participant	262˙875.00
5	UNIVERSITA DEGLI STUDI DI MILANO UNIVERSITA DEGLI STUDI DI MILANO Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 website: www.unimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	258˙061.00
6	DC4U DC4U Organization address address: DE CORRIDOR 21E city: BREUKELEN postcode: 3621 ZA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (BREUKELEN)	participant	255˙374.00
7	STICHTING VUMC STICHTING VUMC Organization address address: DE BOELELAAN 1117 city: AMSTERDAM postcode: 1081 HV website: www.vumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	255˙374.00
8	UNIVERSITEIT LEIDEN UNIVERSITEIT LEIDEN Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2311 EZ website: www.universiteitleiden.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	255˙374.00
9	DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Organization address address: IM NEUENHEIMER FELD 280 city: HEIDELBERG postcode: 69120 website: www.dkfz.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	249˙216.00
10	GLYCOUNIVERSE GMBH & CO. KOMMANDITGESELLSCHAFT AUF AKTIEN GLYCOUNIVERSE GMBH & CO. KOMMANDITGESELLSCHAFT AUF AKTIEN Organization address address: AM MUHLENBERG 11 city: POTSDAM postcode: 14476 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (POTSDAM)	participant	249˙216.00
11	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	249˙216.00
12	STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER Organization address address: BUNTEWEG 2 city: HANNOVER postcode: 30559 website: www.tiho-hannover.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HANNOVER)	participant	249˙216.00
13	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	247˙872.00
14	MIDATECH PHARMA ESPANA SL MIDATECH PHARMA ESPANA SL Organization address address: PARQUE TECNOLOGICO DE BIZKAIA EDIFICIO 800 2A PLANTA city: DERIO postcode: 48160 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (DERIO)	participant	247˙872.00
15	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	0.00
16	UNIVERSITE JOSEPH FOURIER GRENOBLE 1 UNIVERSITE JOSEPH FOURIER GRENOBLE 1 Organization address address: Avenue Centrale, Domaine Universitaire 621 city: GRENOBLE postcode: 38041 website: www.ujf-grenoble.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (GRENOBLE)	participant	0.00
17	GLAXOSMITHKLINE VACCINES SRL GLAXOSMITHKLINE VACCINES SRL Organization address address: VIA FIORENTINA 1 city: SIENA postcode: 53100 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SIENA)	partner	0.00

Map

Project objective

IMMUNOSHAPE aims at training a new generation of scientists that will be capable of combining state of the art synthesis and screening technology to develop new lead structures for highly selective glycan based multivalent immunotherapeutics for the treatment of cancer, autoimmune diseases and allergy. To this end, we have set up a training program in a unique academic-industrial environment that will educate young researchers in scientific and practical biomedical glycoscience with the final aim to produce new talent and innovation in the field and improve their career perspectives in both academic and non-academic sectors. The unique combination of 10 academic groups with expertise in automated solid-phase carbohydrate synthesis, microarray based highthroughput screening technology, tumour immunology, structural glycobiology, multivalent systems and medicinal chemistry along with 4 industrial partners active in nanomedicine, immunotherapy, medicinal device development and the fabrication of scientific instrumentation will provide a multidisciplinary and multisectorial training to 15 ESRs in biomedical glycoscience and its industrial applications.

Deliverables

List of deliverables.
Website online	Websites, patent fillings, videos etc.	2019-09-06 08:37:36
Murine and human CLRs	Documents, reports	2019-09-06 08:37:36
Neoglycoproteins	Documents, reports	2019-09-06 08:37:36
Glycan antigen library	Documents, reports	2019-09-06 08:37:36
Glycan binding of CLRs	Documents, reports	2019-09-06 08:37:36
Cell surface binding	Documents, reports	2019-09-06 08:37:36
Glycodendrimers	Documents, reports	2019-09-06 08:37:36

Take a look to the deliverables list in detail: detailed list of IMMUNOSHAPE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Andreas Geissner, Anika Reinhardt, Christoph Rademacher, Timo Johannssen, JoÃ£o Monteiro, Bernd Lepenies, Michel ThÃ©paut, Franck Fieschi, Jana MrÃ¡zkovÃ¡, Michaela Wimmerova, Frank Schuhmacher, Sebastian GÃ¶tze, Dan GrÃ¼nstein, Xiaoqiang Guo, Heung Sik Hahm, Jeyakumar Kandasamy, Daniele Leonori, Christopher E. Martin, Sharavathi G. Parameswarappa, Sandip Pasari, Mark K. Schlegel, Hidenori Tanaka, Microbe-focused glycan array screening platform published pages: 1958-1967, ISSN: 0027-8424, DOI: 10.1073/pnas.1800853116	Proceedings of the National Academy of Sciences 116/6	2019-10-08
2018	Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto RodrÃguez, Yvette van Kooyk, Sandra J. van Vliet Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2018.00039	Frontiers in Oncology 8	2019-09-06
2018	Alonso Pardo-Vargas, Martina Delbianco, Peter H Seeberger Automated glycan assembly as an enabling technology published pages: 48-55, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2018.04.007	Current Opinion in Chemical Biology 46	2019-09-06
2017	Joao T. Monteiro and Bernd Lepenies Multivalent Lectin-Glycan Interactions in the Immune System published pages: 325-344, ISSN: , DOI:	Multivalency: Concepts, Research and Applications	2019-09-06
2018	Laura Medve, Silvia Achilli, Sonia Serna, Fabio Zuccotto, Norbert Varga, Michel ThÃ©paut, Monica Civera, Corinne VivÃ¨s, Franck Fieschi, Niels Reichardt, Anna Bernardi On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin published pages: 14448-14460, ISSN: 0947-6539, DOI: 10.1002/chem.201802577	Chemistry - A European Journal 24/54	2019-09-06
2017	Anthony Troegeler, Ingrid Mercier, CÃ©line Cougoule, Danilo Pietretti, AndrÃ© Colom, Carine Duval, Thien-Phong Vu Manh, Florence Capilla, Renaud Poincloux, Karine Pingris, JÃ©rÃ´me Nigou, JÃ¶rg Rademann, Marc Dalod, Frank A. W. Verreck, Talal Al Saati, Geanncarlo Lugo-Villarino, Bernd Lepenies, Denis Hudrisier, Olivier Neyrolles C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells published pages: E540-E549, ISSN: 0027-8424, DOI: 10.1073/pnas.1613254114	Proceedings of the National Academy of Sciences 114/4	2019-09-06
2018	Joanna Grabowska, Miguel A. Lopez-Venegas, Alsya J. Affandi, Joke M. M. den Haan CD169+ Macrophages Capture and Dendritic Cells Instruct: The Interplay of the Gatekeeper and the General of the Immune System published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02472	Frontiers in Immunology 9	2019-09-06
2018	Laura Medve, Silvia Achilli, Sonia Serna, Fabio Zuccotto, Norbert Varga, Michel ThÃ©paut, Monica Civera, Corinne VivÃ¨s, Franck Fieschi, Niels Reichardt, Anna Bernardi On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin published pages: 14448-14460, ISSN: 0947-6539, DOI: 10.1002/chem.201802577	Chemistry - A European Journal 24/54	2019-09-06
2018	Joyce LÃ¼bbers, Ernesto RodrÃguez, Yvette van Kooyk Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02807	Frontiers in Immunology 9	2019-09-06
2016	JosÃ© J. Reina, Antonio Di Maio, Javier Ramos-Soriano, Rute C. Figueiredo, Javier Rojo Rapid and efficient synthesis of Î±(1â€“2)mannobiosides published pages: 2873-2882, ISSN: 1477-0520, DOI: 10.1039/C6OB00083E	Org. Biomol. Chem. 14/10	2019-09-06
2017	Ana Gimeno, Niels-Christian Reichardt, F. Javier CaÃ±ada, Lukas Perkams, Carlo Unverzagt, JesÃºs JimÃ©nez-Barbero, Ana ArdÃ¡ NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features published pages: 1104-1112, ISSN: 1554-8929, DOI: 10.1021/acschembio.6b01116	ACS Chemical Biology 12/4	2019-09-06
2017	Y. Y. Michelle Yang, Xiao Hong Li, Katarzyna Brzezicka, Niels-Christian Reichardt, R. Alan Wilson, Angela van Diepen, Cornelis H. Hokke Specific anti-glycan antibodies are sustained during and after parasite clearance in Schistosoma japonicum-infected rhesus macaques published pages: e0005339, ISSN: 1935-2735, DOI: 10.1371/journal.pntd.0005339	PLOS Neglected Tropical Diseases 11/2	2019-09-06
2016	Katarzyna Brzezicka, Uwe Vogel, Sonia Serna, Timo Johannssen, Bernd Lepenies, Niels-Christian Reichardt Influence of Core Î²-1,2-Xylosylation on Glycoprotein Recognition by Murine C-type Lectin Receptors and Its Impact on Dendritic Cell Targeting published pages: 2347-2356, ISSN: 1554-8929, DOI: 10.1021/acschembio.6b00265	ACS Chemical Biology 11/8	2019-09-06
2016	Angela Berzi, Stefania Ordanini, Ben Joosten, Daria Trabattoni, Alessandra Cambi, Anna Bernardi, Mario Clerici Pseudo-Mannosylated DC-SIGN Ligands as Immunomodulants published pages: 35373, ISSN: 2045-2322, DOI: 10.1038/srep35373	Scientific Reports 6	2019-09-06
2017	JoÃ£o Monteiro, Bernd Lepenies Myeloid C-Type Lectin Receptors in Viral Recognition and Antiviral Immunity published pages: 59, ISSN: 1999-4915, DOI: 10.3390/v9030059	Viruses 9/3	2019-09-06
2017	Luca Unione, Maria AlcalÃ¡, BegoÃ±a Echeverria, Sonia Serna, Ana ArdÃ¡, Antonio Franconetti, F. Javier CaÃ±ada, Tammo Diercks, Niels Reichardt, JesÃºs JimÃ©nez-Barbero Fluoroacetamide Moieties as NMR Spectroscopy Probes for the Molecular Recognition of GlcNAc-Containing Sugars: Modulation of the CH-Ï€ Stacking Interactions by Different Fluorination Patterns published pages: 3957-3965, ISSN: 0947-6539, DOI: 10.1002/chem.201605573	Chemistry - A European Journal 23/16	2019-09-06
2017	Ana Gimeno, Niels-Christian Reichardt, F. Javier CaÃ±ada, Lukas Perkams, Carlo Unverzagt, JesÃºs JimÃ©nez-Barbero, Ana ArdÃ¡ NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features published pages: 1104-1112, ISSN: 1554-8929, DOI: 10.1021/acschembio.6b01116	ACS Chemical Biology 12/4	2019-09-06
2016	Niels-Christian Reichardt, Manuel MartÃn-Lomas, Soledad PenadÃ©s Opportunities for glyconanomaterials in personalized medicine published pages: 13430-13439, ISSN: 1359-7345, DOI: 10.1039/C6CC04445J	Chem. Commun. 52/92	2019-09-06
2018	BegoÃ±a Echeverria, Sonia Serna, Silvia Achilli, Corinne VivÃ¨s, Julie Pham, Michel ThÃ©paut, Cornelis H. Hokke, Franck Fieschi, Niels-Christian Reichardt Chemoenzymatic Synthesis of N-glycan Positional Isomers and Evidence for Branch Selective Binding by Monoclonal Antibodies and Human C-type Lectin Receptors published pages: , ISSN: 1554-8929, DOI: 10.1021/acschembio.8b00431	ACS Chemical Biology	2019-09-06
2018	Sabine Mayer, Rebecca Moeller, JoÃ£o T. Monteiro, Kerstin Ellrott, Christine Josenhans, Bernd Lepenies C-Type Lectin Receptor (CLR)â€“Fc Fusion Proteins As Tools to Screen for Novel CLR/Bacteria Interactions: An Exemplary Study on Preselected Campylobacter jejuni Isolates published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00213	Frontiers in Immunology 9	2019-09-06
2018	Chethan D. Shanthamurthy, Prashant Jain, Sharon Yehuda, JoÃ£o T. Monteiro, Shani Leviatan Ben-Arye, Balamurugan Subramani, Bernd Lepenies, Vered Padler-Karavani, Raghavendra Kikkeri ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-24333-y	Scientific Reports 8/1	2019-09-06

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