TUSUPO SIGNED
Tubular Supramolecular Polymers: A new class of therapeutic polymers
Total Cost €
0EC-Contrib. €
0Partnership
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Project "TUSUPO" data sheet
The following table provides information about the project.
| Coordinator |
THE UNIVERSITY OF WARWICK
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 1˙692˙376 € |
| EC max contribution | 1˙692˙376 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-07-01 to 2020-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE UNIVERSITY OF WARWICK | UK (COVENTRY) | coordinator | 1˙692˙376.00 |
Map
Project objective
This research programme will establish a new class of materials and develop them into functional devices for biomedical applications. We will design tubular supramolecular polymers, supramolecular polymer brushes (SPBs), based on the self-assembly of cyclic peptide – polymer conjugates. The synergy between the cyclic peptide, which directs the formation of the SPBs and the polymer conjugate, which provides functionality, will open the route to a wealth of new functional structures. We will build on our initial work and expand our research to generate new synthetic routes for the ligation of polymers to peptides, develop new protocols for the characterisation of the materials, and establish the mechanism of supramolecular polymerisation. This research programme will open new horizons in the fundamental understanding and production of supramolecular polymers. In particular, beyond the generation of new materials, the functionality of these systems may allow the development of supramolecular living polymers, a long-standing goal in polymer chemistry that is still elusive. The functionality and versatility of the SPBs obtained in this work open the route to a wealth of applications, and we will focus on one specific target: the fabrication of drug delivery vectors. We will exploit the unique combination of features presented by this new class of polymer therapeutics, such as multiple attachment points for one or more drug(s) / targeting ligands / markers, the ability to self-disassemble into smaller and easy-to-excrete components, and an elongated shape that enables diffusion and interaction with cells more efficiently than traditional globular delivery systems. We will study the pharmacology properties of the SPBs, including their stability, toxicity, mode of cell penetration and ability to deliver a single or a combination of bioactive agent(s) (in the case of concerted mechanisms).
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Johannes C. Brendel, Joaquin Sanchis, Sylvain Catrouillet, Ewa Czuba, Moore Z. Chen, Benjamin M. Long, Cameron Nowell, Angus Johnston, Katrina A. Jolliffe, Sébastien Perrier Secondary Self-Assembly of Supramolecular Nanotubes into Tubisomes and Their Activity on Cells published pages: 16678-16682, ISSN: 1433-7851, DOI: 10.1002/anie.201808543 |
Angewandte Chemie International Edition 57/51 | 2020-04-01 |
| 2018 |
Huda Shaikh, Julia Y. Rho, Laura J. Macdougall, Pratik Gurnani, Andrew M. Lunn, Jie Yang, Steve Huband, Edward D. H. Mansfield, Raoul Peltier, Sebastien Perrier Hydrogel and Organogel Formation by Hierarchical Self-Assembly of Cyclic Peptides Nanotubes published pages: 19066-19074, ISSN: 0947-6539, DOI: 10.1002/chem.201804576 |
Chemistry - A European Journal 24/71 | 2020-04-01 |
| 2019 |
Qiao Song, Jie Yang, Stephen C. L. Hall, Pratik Gurnani, Sébastien Perrier Pyridyl Disulfide Reaction Chemistry: An Efficient Strategy toward Redox-Responsive Cyclic Peptide–Polymer Conjugates published pages: 1347-1352, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.9b00538 |
ACS Macro Letters 8/10 | 2020-04-01 |
| 2019 |
Matthias Hartlieb, Sylvain Catrouillet, Agnès Kuroki, Carlos Sanchez-Cano, Raoul Peltier, Sébastien Perrier Stimuli-responsive membrane activity of cyclic-peptide–polymer conjugates published pages: 5476-5483, ISSN: 2041-6520, DOI: 10.1039/c9sc00756c |
Chemical Science 10/21 | 2020-04-01 |
| 2019 |
Julia Y. Rho, Henry Cox, Edward D. H. Mansfield, Sean H. Ellacott, Raoul Peltier, Johannes C. Brendel, Matthias Hartlieb, Thomas A. Waigh, Sébastien Perrier Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12586-8 |
Nature Communications 10/1 | 2020-04-01 |
| 2016 |
Sylvain Catrouillet, Johannes C. Brendel, Sophie Larnaudie, Tammie Barlow, Katrina A. Jolliffe, Sébastien Perrier Tunable Length of Cyclic Peptide–Polymer Conjugate Self-Assemblies in Water published pages: 1119-1123, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.6b00586 |
ACS Macro Letters 5/10 | 2020-04-01 |
| 2017 |
Sophie C. Larnaudie, Johannes C. Brendel, Katrina A. Jolliffe, Sébastien Perrier pH-Responsive, Amphiphilic Core–Shell Supramolecular Polymer Brushes from Cyclic Peptide–Polymer Conjugates published pages: 1347-1351, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00728 |
ACS Macro Letters 6/12 | 2020-04-01 |
| 2018 |
Edward D. H. Mansfield, Matthias Hartlieb, Sylvain Catrouillet, Julia Y. Rho, Sophie C. Larnaudie, Sarah E. Rogers, Joaquin Sanchis, Johannes C. Brendel, Sébastien Perrier Systematic study of the structural parameters affecting the self-assembly of cyclic peptide–poly(ethylene glycol) conjugates published pages: 6320-6326, ISSN: 1744-683X, DOI: 10.1039/C8SM01133H |
Soft Matter 14/30 | 2020-04-01 |
| 2018 |
Sophie C. Larnaudie, Joaquin Sanchis, Tri-Hung Nguyen, Raoul Peltier, Sylvain Catrouillet, Johannes C. Brendel, Christopher J.H. Porter, Katrina A. Jolliffe, Sébastien Perrier Cyclic peptide-poly(HPMA) nanotubes as drug delivery vectors: In vitro assessment, pharmacokinetics and biodistribution published pages: 570-582, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.03.047 |
Biomaterials 178 | 2020-04-01 |
| 2017 |
Sophie C. Larnaudie, Johannes C. Brendel, Isolda Romero-Canelón, Carlos Sanchez-Cano, Sylvain Catrouillet, Joaquin Sanchis, James P. C. Coverdale, Ji-Inn Song, Abraha Habtemariam, Peter J. Sadler, Katrina A. Jolliffe, Sébastien Perrier Cyclic Peptide–Polymer Nanotubes as Efficient and Highly Potent Drug Delivery Systems for Organometallic Anticancer Complexes published pages: 239-247, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b01491 |
Biomacromolecules 19/1 | 2020-04-01 |
| 2018 |
Jason G. Binfield, Johannes C. Brendel, Neil R. Cameron, Ahmed M. Eissa, Sébastien Perrier Imaging Proton Transport in Giant Vesicles through Cyclic Peptide-Polymer Conjugate Nanotube Transmembrane Ion Channels published pages: 1700831, ISSN: 1022-1336, DOI: 10.1002/marc.201700831 |
Macromolecular Rapid Communications | 2020-04-01 |
| 2016 |
Moraes, J.; Peltier, R.; Gody, G.; Blum, M.; Recalcati, S.; Klok, H.-H.; Perrier, S. Influence of block versus random monomer distribution on the cellular uptake of hydrophilic copolymers published pages: , ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.6b00652 |
ACS Macro Lett | 2020-04-01 |
| 2017 |
Julia Y. Rho, Johannes C. Brendel, Liam R. MacFarlane, Edward D. H. Mansfield, Raoul Peltier, Sarah Rogers, Matthias Hartlieb, Sébastien Perrier Probing the Dynamic Nature of Self-Assembling Cyclic Peptide-Polymer Nanotubes in Solution and in Mammalian Cells published pages: 1704569, ISSN: 1616-301X, DOI: 10.1002/adfm.201704569 |
Advanced Functional Materials | 2020-04-01 |
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