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Pharmcophore-DOS

Pharmacophore guided diversity-oriented synthesis and its application in discovering inhibitors of protein-protein interactions between RAD51 and BRCA2

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Pharmcophore-DOS project word cloud

Explore the words cloud of the Pharmcophore-DOS project. It provides you a very rough idea of what is the project "Pharmcophore-DOS" about.

professional chemistry rad51 skills cooperation interaction resistance mobility researcher radiotherapy lasting cells guided inhibitors reverse protein action cytotoxic benefitted chemotherapy inside discovery acquire cancer ppi pharmacophore technologies rational spark modulators dos plans host area maturity career discovering scientific medicinal brca2 countries treatment

Project "Pharmcophore-DOS" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www-spring.ch.cam.ac.uk/research/research.shtml
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2017-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	195˙454.00

Map

Project objective

The proposed research aims at discovering inhibitors of protein-protein interaction (PPI) between RAD51 and BRCA2 as a promising treatment of cancer, in particular to reverse the resistance of cancer cells to radiotherapy and cytotoxic chemotherapy. The pharmacophore guided DOS approach developed in this project has the potential to be a general method for rational discovery of PPI modulators. The researcher will acquire novel technologies and develop new skills in both scientific and management aspects, which are important in his professional maturity and career plans; while the host can also be benefitted from his experience in medicinal chemistry. This action will promote the mobility inside the European Research Area and spark lasting cooperation among different European countries.

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The information about "PHARMCOPHORE-DOS" are provided by the European Opendata Portal: CORDIS opendata.