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CONFINES

Controlling Cell Fate through Smart Nanoheaters

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CONFINES project word cloud

Explore the words cloud of the CONFINES project. It provides you a very rough idea of what is the project "CONFINES" about.

fate    time    nanobiotechnology    signalling    complete    multidisciplinarytraining    mode    canonical    activator    activate    technological    invertebratehydra    downstream    death    smart    cell    shape    exposure    forefront    induce    tool    diverse    polarity    basic    nanoheater    central    nanovector    tailor    nanoparticles    synthesis    ligands    complement    proliferation    synthetic    govern    owing    combining    wnt    heat    point    conceived    hyperthermia    holds    uniquenanovector    operate    magnetic    selective    stem    fascinating    view    receiving    nanomaterial    demand    thermal    proof    chemico    bioengineered    physical    dual    cells    promises    nanownt    vivo    characterization    vulgaris    space    translational    achieving    cellular    human    aquatic    fashion    confines    inactive    validate    cultures    medicine    functionalisation    skills    mechanisms    ablation    biology    molecular    vitro    mediated    expertise    intriguing    breakthrough    orchestrates    contexts    nanovectorable   

Project "CONFINES" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE ZARAGOZA 

Organization address
address: CALLE PEDRO CERBUNA 12
city: ZARAGOZA
postcode: 50009
website: www.unizar.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://bionanosurf.unizar.es/projects/confines-h2020-msca-if-2014/
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-09   to  2018-09-09

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE ZARAGOZA ES (ZARAGOZA) coordinator 170˙121.00

Map

 Project objective

Achieving the control of cellular processes is one of the most intriguing challenges in cell biology and medicine. Forefront approaches based on bioengineered nanoparticles might have the potential to target specific cell pathways, thus controlling downstream cell activities in a space and time selective fashion. The present project aims to develop and to validate a smart nanovectorable to activate a specific cell signalling and, on demand, to induce heat mediated cell death of nanovector targeted cells. As proof of concept, CONFINES is conceived to target the Wnt canonical pathway, one of the most studied and fascinating cell signalling, which orchestrates central mechanisms that govern cell proliferation, polarity and stem cell fate. To achieve the proposed objectives, a controlled synthetic approach will tailor Wnt ligands on magnetic nanoparticles, combining targeting and magnetic properties in a uniquenanovector. Owing to its chemico-physical features, NanoWnt will enable complete control of the cell signalling, and it will operate in vitro (human cell cultures) and in vivo (the aquatic invertebrateHydra vulgaris), in a dual mode: i) as an activator of the canonical Wnt pathway in those contexts where it is inactive ii) or upon exposure to a magnetic field, as a nanoheater, enabling specific cell ablation by hyperthermia. From a technological point of view, the project will advance basic knowledge on thermal ablation (via magnetic hyperthermia) and holds promises for translational medicine, providing a breakthrough tool to shape cell fate of nanovector receiving cells. Furthermore, combining diverse expertise, CONFINES will offer the applicant advanced and multidisciplinarytraining in the field of nanomaterial synthesis, characterization and functionalisation as well as in hyperthermia technology, which will complement his current skills based on nanobiotechnology and cellular/molecular biology.

 Publications

year authors and title journal last update
List of publications.
2017 Rafael Martín-Rapun, Laura De Matteis, Alfredo Ambrosone, Sonia Garcia-Embid, Lucia Gutierrez, Jesus M. de la Fuente
Targeted Nanoparticles for the Treatment of Alzheimer\'s Disease
published pages: 1927-1952, ISSN: 1381-6128, DOI: 10.2174/1381612822666161226151011
Current Pharmaceutical Design 23/13 2019-06-13

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The information about "CONFINES" are provided by the European Opendata Portal: CORDIS opendata.

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