Opendata, web and dolomites

CONFINES

Controlling Cell Fate through Smart Nanoheaters

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CONFINES project word cloud

Explore the words cloud of the CONFINES project. It provides you a very rough idea of what is the project "CONFINES" about.

nanownt    vivo    view    cells    confines    vitro    magnetic    functionalisation    receiving    tool    contexts    achieving    skills    nanoheater    nanomaterial    heat    combining    holds    human    bioengineered    mode    forefront    thermal    nanoparticles    proliferation    orchestrates    conceived    ligands    expertise    exposure    dual    point    nanobiotechnology    hyperthermia    ablation    uniquenanovector    death    technological    polarity    translational    central    complement    diverse    activator    downstream    demand    fascinating    molecular    govern    invertebratehydra    promises    fate    time    mechanisms    synthesis    shape    aquatic    wnt    stem    vulgaris    cultures    chemico    complete    nanovectorable    intriguing    inactive    synthetic    canonical    basic    smart    space    validate    activate    fashion    physical    induce    mediated    multidisciplinarytraining    selective    owing    proof    operate    nanovector    cellular    breakthrough    signalling    medicine    cell    tailor    characterization    biology   

Project "CONFINES" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE ZARAGOZA 

Organization address
address: CALLE PEDRO CERBUNA 12
city: ZARAGOZA
postcode: 50009
website: www.unizar.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://bionanosurf.unizar.es/projects/confines-h2020-msca-if-2014/
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-09   to  2018-09-09

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE ZARAGOZA ES (ZARAGOZA) coordinator 170˙121.00

Map

 Project objective

Achieving the control of cellular processes is one of the most intriguing challenges in cell biology and medicine. Forefront approaches based on bioengineered nanoparticles might have the potential to target specific cell pathways, thus controlling downstream cell activities in a space and time selective fashion. The present project aims to develop and to validate a smart nanovectorable to activate a specific cell signalling and, on demand, to induce heat mediated cell death of nanovector targeted cells. As proof of concept, CONFINES is conceived to target the Wnt canonical pathway, one of the most studied and fascinating cell signalling, which orchestrates central mechanisms that govern cell proliferation, polarity and stem cell fate. To achieve the proposed objectives, a controlled synthetic approach will tailor Wnt ligands on magnetic nanoparticles, combining targeting and magnetic properties in a uniquenanovector. Owing to its chemico-physical features, NanoWnt will enable complete control of the cell signalling, and it will operate in vitro (human cell cultures) and in vivo (the aquatic invertebrateHydra vulgaris), in a dual mode: i) as an activator of the canonical Wnt pathway in those contexts where it is inactive ii) or upon exposure to a magnetic field, as a nanoheater, enabling specific cell ablation by hyperthermia. From a technological point of view, the project will advance basic knowledge on thermal ablation (via magnetic hyperthermia) and holds promises for translational medicine, providing a breakthrough tool to shape cell fate of nanovector receiving cells. Furthermore, combining diverse expertise, CONFINES will offer the applicant advanced and multidisciplinarytraining in the field of nanomaterial synthesis, characterization and functionalisation as well as in hyperthermia technology, which will complement his current skills based on nanobiotechnology and cellular/molecular biology.

 Publications

year authors and title journal last update
List of publications.
2017 Rafael Martín-Rapun, Laura De Matteis, Alfredo Ambrosone, Sonia Garcia-Embid, Lucia Gutierrez, Jesus M. de la Fuente
Targeted Nanoparticles for the Treatment of Alzheimer\'s Disease
published pages: 1927-1952, ISSN: 1381-6128, DOI: 10.2174/1381612822666161226151011
Current Pharmaceutical Design 23/13 2019-06-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CONFINES" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CONFINES" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More  

ICL CHROM (2020)

DNA interstrand crosslink repair and chromatin remodelling

Read More  

GENI (2019)

Gender, emotions and national identities: a new perspective on the abortion debates in Italy (1971-1981).

Read More