SexDiff
Sex differences in expression in the shared genome
Total Cost €
0EC-Contrib. €
0Partnership
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Project "SexDiff" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITY COLLEGE LONDON
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Project website | http://www.drbeckydean.com |
| Total cost | 183˙454 € |
| EC max contribution | 183˙454 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-03-01 to 2019-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITY COLLEGE LONDON | UK (LONDON) | coordinator | 183˙454.00 |
Map
Project objective
Males and females in many animals are strikingly different in behaviour, physiology, shape and form. In humans, rates of ageing and disease incidence vary markedly between the sexes. Moreover, sex differences in response to medical therapies and treatments have recently become an area of major biomedical concern. Because there are very few sex-limited genes, sex differences are largely a product of contrasting gene expression patterns between males and females4. Despite their ubiquity and clear biomedical importance, the evolutionary causes of sex differences in gene expression remain essentially unknown and pose a fundamental problem for biologists: How do sex differences evolve given that the sexes largely share the same genome?
My research addresses this fundamental question using two approaches: (1) a data-driven, large-scale phylogenetic approach, and (2) an experimental manipulation of chromosome dose in Drosophila melanogaster. The results from this project will create comprehensive understanding of sex-specific gene regulation and evolution. This broad research has important implications for medical, developmental and evolutionary studies of sex differences and addresses a key aim, as identified by the European Commission, for research excellence in Horizon 2020.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Rebecca Dean, Camille Hammer, Vanessa Higham, Damian K. Dowling Masculinization of gene expression is associated with male quality in Drosophila melanogaster published pages: 2736-2748, ISSN: 0014-3820, DOI: 10.1111/evo.13618 |
Evolution 72/12 | 2019-11-06 |
| 2017 |
Rebecca Dean, Alison E. Wright, Susan E. Marsh-Rollo, Bridget M. Nugent, Suzanne H. Alonzo, Judith E. Mank Sperm competition shapes gene expression and sequence evolution in the ocellated wrasse published pages: 505-518, ISSN: 0962-1083, DOI: 10.1111/mec.13919 |
Molecular Ecology 26/2 | 2019-11-06 |
| 2016 |
Rebecca Dean, Judith E. Mank Tissue Specificity and Sex-Specific Regulatory Variation Permit the Evolution of Sex-Biased Gene Expression published pages: E74-E84, ISSN: 0003-0147, DOI: 10.1086/687526 |
The American Naturalist 188/3 | 2019-11-06 |
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