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RADIOGENFF SIGNED

RADIOGENOMICS: Finding Genetic Functional Variants Through Fine Mapping

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

RADIOGENFF project word cloud

Explore the words cloud of the RADIOGENFF project. It provides you a very rough idea of what is the project "RADIOGENFF" about.

genetically association groups harmonised gain mediate skills researcher patients collaborating molecular variants functional mechanisms risk phenotypes radiation gained snp limited datasets candidates decreased team centre genetic causal power oncoarray radiogenomics massive mapping genome patho completion participating cancer loci frequency bioinformatic narrow validate analysed 5 gwas unintended prostate performed independent epidemiological severely normal constitute fine stream proctitis host radiotherapy damage list local incoming nocturia curative epidemiology additional responsible candidate radiotoxicity meta toxicity urinary carry benefit tissues physiology personalized date genetics

Project "RADIOGENFF" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-04-01 to 2018-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	183˙454.00

Map

Project objective

“Radiogenomics” is the study of the genetics of toxicity following radiotherapy. Unintended damage to normal tissues can severely affect up to 5% of patients for years after completion of curative cancer radiotherapy. To date three Genome Wide Association Studies on radiation toxicity in prostate cancer patients have been performed. These studies have identified genetic loci associated with development of radiation-induced toxicity phenotypes in local tissues. To increase the very limited power of each independent study, the three groups are collaborating on a meta-analysis of harmonised toxicity phenotypes (nocturia, urinary frequency, decreased stream and proctitis) and have identified several promising new loci. The proposed activity at the Centre for Cancer Genetic Epidemiology will be fine-scale mapping of these loci identified with the aim of identifying the genetic variants directly responsible for these toxicity phenotypes. The objectives of the proposed research are: 1. For the Researcher to learn advanced genetic epidemiological and fine-mapping skills by participating in team-based analysis of incoming massive, “OncoArray” datasets – which will be analysed at the host institution; 2. Identify and validate additional novel genetic radiation toxicity loci through analysis of specific radiotoxicity SNP-sets on the “Oncoarray” and through additional GWAS meta-analysis; 3. Apply high-level skills, gained in objective 1, to the fine scale mapping of radiation toxicity loci with the aim of to identifying the top genetic causal candidate variants for radiation toxicity; 4. Carry out bioinformatic functional analysis of the top causal candidates to both narrow the candidate list further, and gain understanding of the molecular patho-physiology and genetic mechanisms that mediate the development of radiation-induced toxicity. Knowledge of these will constitute a further step in identifying genetically at-risk groups likely to benefit from personalized radiotherapy.

Publications

List of publications.
year	authors and title	journal	last update
2017	Christopher I. Amos, Joe Dennis, Zhaoming Wang, Jinyoung Byun, Fredrick R. Schumacher, Simon A. Gayther, Graham Casey, David J. Hunter, Thomas A. Sellers, Stephen B. Gruber, Alison M. Dunning, Kyriaki Michailidou, Laura Fachal, Kimberly Doheny, Amanda B. Spurdle, Yafang Li, Xiangjun Xiao, Jane Romm, Elizabeth Pugh, Gerhard A. Coetzee, Dennis J. Hazelett, Stig E. Bojesen, Charlisse Caga-Anan, Christopher A. Haiman, Ahsan Kamal, Craig Luccarini, Daniel Tessier, Daniel Vincent, FranÃ§ois Bacot, David J. Van Den Berg, Stefanie Nelson, Stephen Demetriades, David E. Goldgar, Fergus J. Couch, Judith L. Forman, Graham G. Giles, David V. Conti, Heike BickebÃ¶ller, Angela Risch, Melanie Waldenberger, Irene BrÃ¼ske-Hohlfeld, Belynda D. Hicks, Hua Ling, Lesley McGuffog, Andrew Lee, Karoline Kuchenbaecker, Penny Soucy, Judith Manz, Julie M. Cunningham, Katja Butterbach, Zsofia Kote-Jarai, Peter Kraft, Liesel FitzGerald, Sara LindstrÃ¶m, Marcia Adams, James D. McKay, Catherine M. Phelan, Sara Benlloch, Linda E. Kelemen, Paul Brennan, Marjorie Riggan, Tracy A. O\'Mara, Hongbing Shen, Yongyong Shi, Deborah J. Thompson, Marc T. Goodman, Sune F. Nielsen, Andrew Berchuck, Sylvie Laboissiere, Stephanie L. Schmit, Tameka Shelford, Christopher K. Edlund, Jack A. Taylor, John K. Field, Sue K. Park, Kenneth Offit, Mads Thomassen, Rita Schmutzler, Laura Ottini, Rayjean J. Hung, Jonathan Marchini, Ali Amin Al Olama, Ulrike Peters, Rosalind A. Eeles, Michael F. Seldin, Elizabeth Gillanders, Daniela Seminara, Antonis C. Antoniou, Paul D.P. Pharoah, Georgia Chenevix-Trench, Stephen J. Chanock, Jacques Simard, Douglas F. Easton The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers published pages: 126-135, ISSN: 1055-9965, DOI: 10.1158/1055-9965.EPI-16-0106	Cancer Epidemiology Biomarkers & Prevention 26/1	2019-06-13
2017	Kyriaki Michailidou, Sara LindstrÃ¶m, Joe Dennis, Jonathan Beesley, Shirley Hui, Siddhartha Kar, Audrey LemaÃ§on, Penny Soucy, Dylan Glubb, Asha Rostamianfar, Manjeet K. Bolla, Qin Wang, Jonathan Tyrer, Ed Dicks, Andrew Lee, Zhaoming Wang, Jamie Allen, Renske Keeman, Ursula Eilber, Juliet D. French, Xiao Qing Chen, Laura Fachal, Karen McCue, Amy E. McCart Reed, Maya Ghoussaini, Jason S. Carroll, Xia Jiang, Hilary Finucane, Marcia Adams, Muriel A. Adank, Habibul Ahsan, Kristiina AittomÃ¤ki, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Kristan J. Aronson, Banu Arun, Paul L. Auer, FranÃ§ois Bacot, Myrto Barrdahl, Caroline Baynes, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Leslie Bernstein, Carl Blomqvist, Natalia V. Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Anne-Lise BÃ¸rresen-Dale, Judith S. Brand, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Louise Brinton, Per Broberg, Ian W. Brock, Annegien Broeks, Angela Brooks-Wilson, Sara Y. Brucker, Thomas BrÃ¼ning, Barbara Burwinkel, Katja Butterbach, Qiuyin Cai, Hui Cai, Trinidad CaldÃ©s, Federico Canzian, Angel Carracedo, Brian D. Carter, Jose E. Castelao, Tsun L. Chan, Ting-Yuan David Cheng, Kee Seng Chia, Ji-Yeob Choi, Hans Christiansen, Christine L. Clarke, Margriet CollÃ©e, Don M. Conroy, Emilie Cordina-Duverger, Sten Cornelissen, David G. Cox, Angela Cox, Simon S. Cross, Julie M. Cunningham, Kamila Czene, Mary B. Daly, Peter Devilee, Kimberly F. Doheny, Thilo DÃ¶rk, Isabel dos-Santos-Silva, Martine Dumont, Lorraine Durcan, Miriam Dwek, Diana M. Eccles, Arif B. Ekici, A. Heather Eliassen, Carolina Ellberg, Mingajeva Elvira, Christoph Engel, Mikael Eriksson, Peter A. Fasching, Jonine Figueroa, Dieter Flesch-Janys, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Valerie Gaborieau, Marike Gabrielson, Manuela Gago-Dominguez, Yu-Tang Gao, Susan M. Gapstur, JosÃ© A. GarcÃa-SÃ¡enz, Mia M. Gaudet, Vassilios Georgoulias, Graham G. Giles, Gord Glendon, Mark S. Goldberg, David E. Goldgar, Anna GonzÃ¡lez-Neira, Grethe I. Grenaker AlnÃ¦s, Mervi Grip, Jacek Gronwald, Anne Grundy, Pascal GuÃ©nel, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas HÃ¥kansson, Ute Hamann, Nathalie Hamel, Susan Hankinson, Patricia Harrington, Steven N. Hart, Jaana M. Hartikainen, Mikael Hartman, Alexander Hein, Jane Heyworth, Belynda Hicks, Peter Hillemanns, Dona N. Ho, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Ming-Feng Hou, Chia-Ni Hsiung, Guanmengqian Huang, Keith Humphreys, Junko Ishiguro, Hidemi Ito, Motoki Iwasaki, Hiroji Iwata, Anna Jakubowska, Wolfgang Janni, Esther M. John, Nichola Johnson, Kristine Jones, Michael Jones, Arja Jukkola-Vuorinen, Rudolf Kaaks, Maria Kabisch, Katarzyna Kaczmarek, Daehee Kang, Yoshio Kasuga, Michael J. Kerin, Sofia Khan, Elza Khusnutdinova, Johanna I. Kiiski, Sung-Won Kim, Julia A. Knight, Veli-Matti Kosma, Vessela N. Kristensen, Ute KrÃ¼ger, Ava Kwong, Diether Lambrechts, Loic Le Marchand, Eunjung Lee, Min Hyuk Lee, Jong Won Lee, Chuen Neng Lee, Flavio Lejbkowicz, Jingmei Li, Jenna Lilyquist, Annika Lindblom, Jolanta Lissowska, Wing-Yee Lo, Sibylle Loibl, Jirong Long, Artitaya Lophatananon, Jan Lubinski, Craig Luccarini, Michael P. Lux, Edmond S. K. Ma, Robert J. MacInnis, Tom Maishman, Enes Makalic, Kathleen E. Malone, Ivana Maleva Kostovska, Arto Mannermaa, Siranoush Manoukian, JoAnn E. Manson, Sara Margolin, Shivaani Mariapun, Maria Elena Martinez, Keitaro Matsuo, Dimitrios Mavroudis, James McKay, Catriona McLean, Hanne Meijers-Heijboer, Alfons Meindl, Primitiva MenÃ©ndez, Usha Menon, Jeffery Meyer, Hui Miao, Nicola Miller, Nur Aishah Mohd Taib, Kenneth Muir, Anna Marie Mulligan, Claire Mulot, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, Sune F. Nielsen, Dong-Young Noh, BÃ¸rge G. Nordestgaard, Aaron Norman, Olufunmilayo I. Olopade, Janet E. Olson, HÃ¥kan Olsson, Curtis Olswold, Nick Orr, V. Shane Pankratz, Sue K. Park, Tjoung-Won Park-Simon, Rachel Lloyd, Jose I. A. Perez, Paol Association analysis identifies 65 new breast cancer risk loci published pages: 92-94, ISSN: 0028-0836, DOI: 10.1038/nature24284	Nature 551/7678	2019-06-13

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