Opendata, web and dolomites

IMSTREV

Immune modulation by lymph node stromal cell-derived extracellular vesicles

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 IMSTREV project word cloud

Explore the words cloud of the IMSTREV project. It provides you a very rough idea of what is the project "IMSTREV" about.

proof    reticular    thymus    peripheral    tested    immune    decipher    laid    tregs    differences    microbiota    pln    microenvironment    autoimmune    ln    emphasis    maintenance    treg    capacity    suggest    critical    intestinal    ve    homeostasis    inducing    lns    crispr    rna    generation    modulate    skin    display    treat    stromal    commensal    secreted    immortalized    formally    cells    attributed    commensals    mechanisms    candidate    discriminate    mass    mediate    fibroblastic    mesenteric    data    mucosa    tolerance    molecules    cellular    imprinted    pathogens    subcellular    molecular    accordingly    tools    dynamic    preliminary    soluble    special    shown    inflammatory    anticipates    interactions    chronic    therapeutic    frcs    gut    na    edited    communication    genome    evs    mln    details    functional    intercellular    modulatory    cas9    diseases    gaining    nodes    regulatory    differentiation    spectrometry    draining    iuml    periphery    primarily    vaccine    lymph    vesicles    newly    extracellular    site    seq   

Project "IMSTREV" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH 

Organization address
address: INHOFFENSTRASSE 7
city: BRAUNSCHWEIG
postcode: 38124
website: www.helmholtz-hzi.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.helmholtz-hzi.de/exim
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH DE (BRAUNSCHWEIG) coordinator 171˙460.00

Map

 Project objective

Regulatory T cells (Tregs) are essential for maintenance of immune homeostasis and peripheral tolerance. The unique challenge to discriminate between pathogens and commensals requires the dynamic adaptation of Tregs to the microenvironment, particularly in the intestinal mucosa. Accordingly, although Tregs are primarily generated in the thymus, they can be also generated in the periphery, and gut-draining mesenteric lymph nodes (mLN) were shown to display a higher Treg-inducing capacity compared to skin-draining peripheral LNs (pLN). Our previous data suggest that these site-specific functional differences of LNs can be attributed to fibroblastic reticular stromal cells (FRCs), and the high Treg-inducing capacity of mLN can be imprinted in LN stromal cells by commensal microbiota. To decipher the molecular details of these site-specific immune-modulatory differences we generated immortalized FRCs, and preliminary data suggest that soluble factors secreted by mLN-derived FRCs mediate the high Treg-inducing capacity of mLN. The present proposal aims to identify molecules secreted from mLN-FRCs that modulate the differentiation of naïve T cells into Tregs. Special emphasis will be laid on the novel field of intercellular communication by extracellular vesicles (EVs), and both RNA-Seq and mass spectrometry approaches will be applied to identify the critical factors on a molecular level. To formally proof the functional importance of the newly identified candidate molecules, immortalized FRCs will be genome-edited using CRISPR-Cas9 technology and tested for their Treg-inducing capacity. Gaining insight into the cellular-subcellular interactions and major molecular mechanisms of peripheral tolerance and Treg generation anticipates promising tools for future vaccine development and therapeutic applications to treat chronic inflammatory and autoimmune diseases.

 Publications

year authors and title journal last update
List of publications.
2017 Maria Pasztoi, Joern Pezoldt, Michael Beckstette, Christoph Lipps, Dagmar Wirth, Manfred Rohde, Krisztina Paloczi, Edit Iren Buzas, Jochen Huehn
Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3 + regulatory T cells
published pages: , ISSN: 0014-2980, DOI: 10.1002/eji.201746960
European Journal of Immunology 2019-07-23

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IMSTREV" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IMSTREV" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CHES (2020)

Resilience of Coastal Human-Environment Systems

Read More  

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More  

MarshFlux (2020)

The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshes

Read More