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embryonic rosettes

Investigating embryonic development at the time of implantation using embryos and ES cells

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

embryonic rosettes project word cloud

Explore the words cloud of the embryonic rosettes project. It provides you a very rough idea of what is the project "embryonic rosettes" about.

proteins es rosettes preimplantation hidden embryonic rosette extensively embryo structure previously implantation model human explants altogether pluripotent point autonomous influence flanking epiblast tissues patterns experiments developmental characterise recapitulated gastrulation expand excellent matrix cultured mouse cells manipulate normal extraembryonic extracellular vitro uterus time revealed view stages

Project "embryonic rosettes" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://zernickagoetzlab.pdn.cam.ac.uk/research.html
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-02-01 to 2018-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	183˙454.00

Map

Project objective

The mouse embryo is an excellent model for human development. Its preimplantation stages of development in vitro have been extensively studied. Now similar approaches can be applied to implantation stages, previously hidden from view in the uterus. It was recently revealed that formation of a rosette structure by pluripotent epiblast cells can be recapitulated by ES cells cultured in extracellular matrix proteins. I will determine the extent to which such rosettes can undertake autonomous development or if they require flanking extraembryonic tissues. I will characterise the patterns of the normal development of these tissues from the point of implantation to the time of gastrulation. I will determine the extent to which explants of extraembryonic tissues can influence the development of rosettes of epiblast cells. Altogether, these experiments will expand our knowledge of embryonic development and how to manipulate the developmental potential of pluripotent cells.

Publications

List of publications.
year	authors and title	journal	last update
2016	Mubeen Goolam, Antonio Scialdone, SarahÂ J.L. Graham, IainÂ C. Macaulay, Agnieszka Jedrusik, Anna Hupalowska, Thierry Voet, JohnÂ C. Marioni, Magdalena Zernicka-Goetz Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos published pages: 61-74, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.01.047	Cell 165/1	2019-06-14

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