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MIPZ SIGNED

Functional characterization of the cell division inhibitor MipZ

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MIPZ project word cloud

Explore the words cloud of the MIPZ project. It provides you a very rough idea of what is the project "MIPZ" about.

disassembly    mass    polar    mediated    gradients    parb    previously    manner    immobilized    cycle    assembly    simplistic    plasmon    dimers    techniques    dynamic    function    isolated    spontaneous    polymerization    microscopy    characterizing    biological    dna    gradient    mutants    centromere    resonance    atp    hydrogen    thereby    positioning    dimerize    inhibit    poles    releasing    near    hydrolysis    centre    monomers    inhibits    surface    antagonizing    triggers    thermophoresis    minimum    concentration    rebuild    dissociate    protein    biochemistry    hybrid    midcell    gain    fluorescence    spatiotemporal    questions    form    recaptured    microscale    cell    diffusible    combination    loop    biophysical    synthetic    cytokinesis    caulobacter    generation    defects    stimulates    interaction    ftsz    limiting    spectrometry    conserved    normal    forming    atpase    mipz    exchange    offspring    division    interact    crescentus    divisome    correct    chromosomal    plane    unknown    bipolar    dimer    dependent    complexes    deuterium    binding    localization    bound   

Project "MIPZ" data sheet

The following table provides information about the project.

Coordinator
PHILIPPS UNIVERSITAET MARBURG 

Organization address
address: BIEGENSTRASSE 10
city: MARBURG
postcode: 35037
website: www.uni-marburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.thanbichlerlab.org/research.html
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-08-03   to  2018-04-09

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PHILIPPS UNIVERSITAET MARBURG DE (MARBURG) coordinator 159˙460.00

Map

 Project objective

Correct positioning of the division plane is essential for the generation of normal offspring. In Caulobacter crescentus, the spatiotemporal control of cell division is mediated by MipZ, a conserved P-loop ATPase forming bipolar gradients with a concentration minimum at the cell centre. Antagonizing the polymerization of the essential divisome component FtsZ, MipZ inhibits divisome assembly near the poles, thereby limiting cytokinesis to midcell. Gradient formation involves a dynamic localization cycle, in which freely diffusible MipZ monomers interact with polar complexes of the centromere-binding protein ParB and then dimerize in an ATP-dependent manner. Dimers dissociate from ParB and are immobilized within the cell through non-specific interaction with chromosomal DNA. Spontaneous ATP hydrolysis triggers disassembly of the complex, releasing MipZ monomers that are recaptured by ParB. How ParB stimulates dimer formation and how DNA-bound dimers inhibit FtsZ assembly is still unknown. We will address these questions by characterizing previously isolated MipZ mutants with FtsZ/ParB interaction defects, using a combination of fluorescence microscopy, two-hybrid analysis, biochemistry, and biophysical techniques such as surface plasmon resonance, microscale thermophoresis or hydrogen-deuterium-exchange mass spectrometry. We will also use synthetic biological and modelling approaches to rebuild the system in a simplistic form to thus gain in-depth knowledge of the function of the different elements.

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The information about "MIPZ" are provided by the European Opendata Portal: CORDIS opendata.

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