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SELECT-A-PROTEIN

Mixed brushes of stimuli-responsive polymers for the selective adsorption of proteins

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SELECT-A-PROTEIN project word cloud

Explore the words cloud of the SELECT-A-PROTEIN project. It provides you a very rough idea of what is the project "SELECT-A-PROTEIN" about.

adsorbed first time drug interactions dissociation surfaces variations materials spectrometry procedure scientific prepare biotechnological material science biomedical tof interfaces temporally mass biosensors strategies medium selective heart sims adsorption molecular polymer rests strength brushes ionic influence strategy protein ph ion adsorb flight weight adjusting manner smart selectively advanced cellular tuned dna mixed proteins surrounding mixture biomolecules implants benefit catheters designing degree model conformation sensitive distinguish created secondary

Project "SELECT-A-PROTEIN" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE CATHOLIQUE DE LOUVAIN Organization address address: PLACE DE L UNIVERSITE 1 city: LOUVAIN LA NEUVE postcode: 1348 website: www.uclouvain.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Project website	https://uclouvain.be/en/research-institutes/imcn/bsma/anna-bratek-skicki-s-marie-curie-fellowship-project.html
Total cost	172˙800 €
EC max contribution	172˙800 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2017-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE CATHOLIQUE DE LOUVAIN UNIVERSITE CATHOLIQUE DE LOUVAIN Organization address address: PLACE DE L UNIVERSITE 1 city: LOUVAIN LA NEUVE postcode: 1348 website: www.uclouvain.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LOUVAIN LA NEUVE)	coordinator	172˙800.00

Map

Project objective

Advanced materials are at the heart of many scientific fields, particularly in the biomedical and biotechnological areas. Many devices (e.g., biosensors, implants, catheters, and systems for drug delivery) would benefit from an effective control over molecular and cellular interactions at material surfaces. Main challenges in this field include the control of biomolecules (e.g., proteins, DNA) adsorption on different surfaces. Designing surfaces that allow proteins to be adsorbed in a controlled manner is particularly important and challenging. Many strategies were recently developed to spatially or temporally control protein adsorption. In this project, a novel strategy for selective protein adsorption from a mixture of proteins will be developed. This strategy will be based on the use of mixed polymer brushes sensitive to ionic strength and pH of the surrounding medium. The project rests on the following steps: i. The design of mixed polymer brushes whose properties will be tuned by adjusting pH and ionic strength of the medium. The influence of polymer properties (molecular weight, and degree of dissociation and conformation through pH and ionic strength variations) on protein adsorption will be studied. ii. The development of a procedure, based on time-of-flight secondary ion mass spectrometry (ToF-SIMS), to distinguish different proteins adsorbed together on model interfaces. iii. The use of this ToF-SIMS-based procedure to investigate the potential of the created mixed brushes to selectively adsorb one protein, at first from a mixture of two or three proteins, and then from a more complex medium. The results obtained in this work will be significant for material science and biomedical applications through the development of a robust procedure to prepare “smart” surfaces with novel properties to control protein adsorption.

Publications

List of publications.
year	authors and title	journal	last update
2017	A. vander Straeten, A. Bratek-Skicki, L. Germain, C. D\'Haese, P. Eloy, C.-A. Fustin, C. Dupont-Gillain Proteinâ€“polyelectrolyte complexes to improve the biological activity of proteins in layer-by-layer assemblies published pages: 17186-17192, ISSN: 2040-3364, DOI: 10.1039/c7nr04345g	Nanoscale 9/44	2019-06-18

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