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Multidyn

Patented advanced low-cost multiwell cell-culture system for in-vitro physiologically relevant biomarker screening

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Multidyn project word cloud

Explore the words cloud of the Multidyn project. It provides you a very rough idea of what is the project "Multidyn" about.

culture screening tested assays model equipped market valuable power gain critical organs adipose cells laws nevertheless diabetes laboratories influence pathobiology multidyn invaluable discovery 24 cultures imaging vascular cellular clinical environment suitable tissues scaffdex pharmacology properly biomarkers ivtech disease hypothesis faster multiwell screen trl decision content performing liver realize endothelium cheaper stem plate decisions allometric tools enhanced techniques investigation predictive utility celltool clear understand biomarker cell chambers patented complexity vitro flow made respondent standard scaling scaffolds human away scientific physiologically industrialize 3d complying protocols intends physiology internal connection drug differentiated primary

Project "Multidyn" data sheet

The following table provides information about the project.

Coordinator	IVTECH SRL Organization address address: via di Bagnaia city: Massarosa postcode: 55054 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.ivtech.it
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SMEINST-1-2014
Funding Scheme	SME-1
Starting year	2015
Duration (year-month-day)	from 2015-02-01 to 2015-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IVTECH SRL IVTECH SRL Organization address address: via di Bagnaia city: Massarosa postcode: 55054 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Massarosa)	coordinator	50˙000.00
2	CELLTOOL GMBH CELLTOOL GMBH Organization address address: Am Neuland 1 city: BERNRIED postcode: 82347 website: www.celltool.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERNRIED)	participant	0.00
3	SCAFFDEX OY SCAFFDEX OY Organization address address: KALKUNKATU 21 B city: TAMPERE postcode: 33330 website: www.scaffdex.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (TAMPERE)	participant	0.00

Map

Project objective

Biomarkers in discovery are valuable tools to understand the pathobiology of a disease and the pharmacology of a target under investigation. In-vitro screen would be invaluable in identifying working hypothesis early in drug development process. Information provided by properly selected biomarkers can greatly influence a go/no go decision. The challenge is to identify relevant biomarkers early enough to implement them for such critical decisions. In developing in-vitro assays to identify biomarkers with potential clinical application and utility, a clear understanding and determination of what that biomarker will assess must be defined. More reliable biomarker screening protocols based on allometric scaling laws are needed to be implemented in order to gain results more respondent to human physiology. The predictive power of High Content Screening techniques can be enhanced by working with primary cells or differentiated stem cells and in 3-D culture. Nevertheless, in-vitro cell cultures are still far away from the complexity of human tissues or organs. IVTech intends to industrialize and test Multidyn, a patented advanced low-cost cell culture system made up by a 24-chambers plate complying with the multiwell standard, capable of any internal connection and flow within the cells, able to realize cheaper faster in-vitro physiologically relevant cellular systems. Multidyn will be tested for early diabetes biomarker discovery by using a developed model of liver, vascular endothelium and adipose tissues, and when equipped with the highly performing 3D scaffolds provided by the partner Scaffdex and with suitable High Content Imaging systems provided by the partner Celltool and selected scientific laboratories. IVTech’ Multidyn is at TRL 6. Phase 1 project will assess the activities needed to demonstrate the product in operational environment with potential end-users, establish a large scale production and test the market.

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The information about "MULTIDYN" are provided by the European Opendata Portal: CORDIS opendata.