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MULTICONNECT SIGNED

Imaging Brain Circuits to Decode Brain Computations: Multimodal Multiscale Imaging of Cortical Microcircuits to Model Predictive Coding in Human Vision

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MULTICONNECT project word cloud

Explore the words cloud of the MULTICONNECT project. It provides you a very rough idea of what is the project "MULTICONNECT" about.

hypothesis significantly motion reference neocortex largely visual ultra image predictive cognition multiple investigates compute provides strengths whereas resonance mt magnetic microcircuitry variations imaging completion core biological unknown microcircuits 7t understand spatial central diffusion computational light uhf leads v5 neocortical human cortical function performed repeating computations apparent scales connections prominent architecture successful networks connectomic basis v1 multiscale functional microscale perception workpackages structural became connectivity generative exist data theory structure grounded models canonical circuits wp mesoscale mri coding move microscopy microcircuit combined circuit back brain

Project "MULTICONNECT" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2020-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	coordinator	1˙500˙000.00

Map

Project objective

The human brain is one of the largest and most complex biological networks known to exist. The architecture of its circuits, and therefore the computational basis of human cognition, remains largely unknown. The central aim of this proposal is to image human cortical connectivity at multiple spatial scales in order to understand human cortical computations. Whereas canonical cortical microcircuits are an established theory of the repeating structure of the neocortex’s circuits, predictive coding provides a prominent proposal of what these circuits compute. This leads to the core hypothesis of this proposal: the variations in predictive coding computations performed by human cortical microcircuits in different visual areas are grounded in variations in their microcircuit connectivity. As a central case-study, this proposal investigates human visual apparent motion perception in V1/2/3 and V5/MT. The proposed research program is organized in two workpackages (WP I and II). WP I has the aim of imaging the multiscale connections of human neocortical microcircuits. The projects in WP I focus on structure and move from the mesoscale down to the microscale. WP II has the aim of modelling how microcircuits support predictive coding computations. The projects in WP II focus on function and move from the microscale back up to the mesoscale. Structural and functional assessment of microcircuitry in the human brain only recently became possible with the development of magnetic resonance imaging (MRI) at ultra-high field-strengths (UHF) of 7T and above. UHF diffusion MRI, combined with light microscopy, is used to image circuit structure in WP I. UHF functional MRI is used for computational modelling of computations in WP II. Successful completion of the planned research will significantly advance our understanding of the computations in cortical microcircuits, deliver important new human connectomic reference data, and improve generative models of human cortical processing.

Publications

List of publications.
year	authors and title	journal	last update
2019	F.J. Fritz, S. Sengupta, R.L. Harms, D.H. Tse, B.A. Poser, A. Roebroeck Ultra-high resolution and multi-shell diffusion MRI of intact ex vivo human brains using kT-dSTEAM at 9.4T published pages: 116087, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2019.116087	NeuroImage 202	2020-02-05
2018	Robbert L. Harms, Alard Roebroeck Robust and Fast Markov Chain Monte Carlo Sampling of Diffusion MRI Microstructure Models published pages: , ISSN: 1662-5196, DOI: 10.3389/fninf.2018.00097	Frontiers in Neuroinformatics 12	2020-02-05
2017	Martin Havlicek, Dimo Ivanov, Alard Roebroeck, Kamil UludaÄŸ Determining Excitatory and Inhibitory Neuronal Activity from Multimodal fMRI Data Using a Generative Hemodynamic Model published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2017.00616	Frontiers in Neuroscience 11	2019-05-29
2016	Silvia De Santis, Derek K. Jones, Alard Roebroeck Including diffusion time dependence in the extra-axonal space improves in vivo estimates of axonal diameter and density in human white matter published pages: 91-103, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2016.01.047	NeuroImage 130	2019-05-29
2017	Martin Havlicek, Alard Roebroeck, Karl J. Friston, Anna Gardumi, Dimo Ivanov, Kamil Uludag On the importance of modeling fMRI transients when estimating effective connectivity: A dynamic causal modeling study using ASL data published pages: 217-233, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.03.017	NeuroImage 155	2019-05-29
2018	Roebroeck, Alard; Galuske, Ralf; Herrler, Andreas; Schueth, Anna; Hildebrand, Sven Scalable cytoarchitectonic characterization of large intact human neocortex samples published pages: , ISSN: , DOI: 10.1101/274985	1	2019-05-29
2016	Silvia De Santis, Yaniv Assaf, Ben Jeurissen, Derek K Jones, Alard Roebroeck T1 relaxometry of crossing fibres in the human brain published pages: 133-142, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2016.07.037	NeuroImage 141	2019-05-29
2016	Birgit R. Plantinga, Alard Roebroeck, Valentin G. Kemper, KÃ¢mil UludaÄŸ, Maartje Melse, JÃ¼rgen Mai, Mark L. Kuijf, Andreas Herrler, Ali Jahanshahi, Bart M. ter Haar Romeny, Yasin Temel Ultra-High Field MRI Post Mortem Structural Connectivity of the Human Subthalamic Nucleus, Substantia Nigra, and Globus Pallidus published pages: , ISSN: 1662-5129, DOI: 10.3389/fnana.2016.00066	Frontiers in Neuroanatomy 10	2019-05-29
2017	R.L. Harms, F.J. Fritz, A. Tobisch, R. Goebel, A. Roebroeck Robust and fast nonlinear optimization of diffusion MRI microstructure models published pages: 82-96, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.04.064	NeuroImage 155	2019-05-29
2016	Shubharthi Sengupta, Alard Roebroeck, Valentin G. Kemper, Benedikt A. Poser, Jan Zimmermann, Rainer Goebel, Gregor Adriany A Specialized Multi-Transmit Head Coil for High Resolution fMRI of the Human Visual Cortex at 7T published pages: e0165418, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0165418	PLOS ONE 11/12	2019-05-29
2016	Matteo Bastiani, Ana-Maria Oros-Peusquens, Arne Seehaus, Daniel Brenner, Klaus MÃ¶llenhoff, Avdo Celik, JÃ¶rg Felder, HansjÃ¼rgen Bratzke, Nadim J. Shah, Ralf Galuske, Rainer Goebel, Alard Roebroeck Automatic Segmentation of Human Cortical Layer-Complexes and Architectural Areas Using Ex vivo Diffusion MRI and Its Validation published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2016.00487	Frontiers in Neuroscience 10	2019-05-29

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The information about "MULTICONNECT" are provided by the European Opendata Portal: CORDIS opendata.