Explore the words cloud of the CAPTURE-CTC project. It provides you a very rough idea of what is the project "CAPTURE-CTC" about.
The following table provides information about the project.
Coordinator |
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Organization address contact info |
Coordinator Country | Germany [DE] |
Total cost | 149˙750 € |
EC max contribution | 149˙750 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2014-PoC |
Funding Scheme | ERC-POC |
Starting year | 2015 |
Duration (year-month-day) | from 2015-06-01 to 2016-11-30 |
Take a look of project's partnership.
# | ||||
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1 | UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF | DE (HAMBURG) | coordinator | 149˙750.00 |
The main cause of death in cancer patients is not the primary tumor but rather metastasis, which is initiated by the spread of circulating tumor cells (CTCs) in the blood. Therefore, CTCs will become a valuable diagnostic tool, once a reliable, cost-effective method is established. Research in the ongoing ERC Advanced Investigator Grant DISSECT (PI: Klaus Pantel) has revealed clear limitations of existing platforms for the detection of CTCs. The enrichment and identification of CTCs out of a blood sample is still a major challenge, mainly because the ratio between CTCs and blood cells is approximately 1:109. The proposed CAPTURE-CTC project is based on this knowledge and aimed to develop and validate a novel improved platform for CTC detection: Pumping a suspension of blood cells through a microfluidic chip, only labeled CTCs get immobilized on a micro-pattern due to strong biotin-streptavidin interaction. Single cell analysis can be performed after the cells are quantified, optically localized and extracted from the pattern with a micro-capillary. This platform will be validated on cancer patients. The detection of CTCs is a very active field, targeted by several SMEs with approaches in different stages of development and/or clinical application. However, the only FDA-cleared assay for CTC detection is the “CellSearch CTC Test” which will be the benchmark in regard to performance, validity of results and cost per test. The CellSearch system has technical limitations (e.g., EpCAM-negative CTCs are not captured and it is a closed system that allows no easy access to the captured CTCs for subsequent molecular characterization analyses). Our proposed CAPTURE-CTC system will constitute a novel platform that will overcome these important limitations and establish an easy-to-use blood test allows further downstream analyses of CTCs as a “liquid biopsy” relevant to personalized cancer medicine.
year | authors and title | journal | last update |
---|---|---|---|
2015 |
Falko Brinkmann, Michael Hirtz, Anna Haller, Tobias M. Gorges, Michael J. Vellekoop, Sabine Riethdorf, Volkmar Müller, Klaus Pantel, Harald Fuchs A Versatile Microarray Platform for Capturing Rare Cells published pages: 15342, ISSN: 2045-2322, DOI: 10.1038/srep15342 |
Scientific Reports 5 | 2019-07-25 |
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