Opendata, web and dolomites
BioAqua SIGNED
Water as cosubstrate for biocatalytic redox reactions
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0BioAqua project word cloud
Explore the words cloud of the BioAqua project. It provides you a very rough idea of what is the project "BioAqua" about.
blocks
hence
light
extremely
redox
preparative
oxidation
glucose
catalysts
wasted
efficient
valuable
edible
visible
entirely
kinetic
water
energy
photocatalysis
sacrificial
paradigm
bridge
once
bioaqua
first
chemical
breaking
cosubstrates
envision
area
electrons
ground
activating
thermodynamic
chemistry
liberated
cosubstrate
reactions
economic
cleaner
catalysed
thereby
organic
completely
building
donor
class
transformations
donors
source
inertness
time
industrial
biocatalytic
schemes
mentioned
ethical
environmental
enzymes
instead
synthesis
utilizing
reaction
made
external
purpose
alcohols
electron
utilises
gap
biocatalysis
bio
oxidoreductases
catalysis
difficult
abundant
food
Project "BioAqua" data sheet
The following table provides information about the project.
| Coordinator |
TECHNISCHE UNIVERSITEIT DELFT
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 1˙998˙020 € |
| EC max contribution | 1˙998˙020 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-07-01 to 2020-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | TECHNISCHE UNIVERSITEIT DELFT | NL (DELFT) | coordinator | 1˙998˙020.00 |
Map
Project objective
The research proposed in BioAqua aims at breaking new ground in the area of catalysis by enabling water-driven biocatalytic redox reactions.
Oxidoreductases are a class of enzymes with a very high potential for preparative organic synthesis, which is why they are increasingly used also on industrial scale. The current state-of-the-art, however, utilises valuable high-energy cosubstrates (such as glucose and alcohols) to promote oxidoreductases. Thereby valuable (and edible) building blocks are wasted as sacrificial electron donors which will have significant ethical (food for chemistry), economic and environmental consequences once redox biocatalysis is applied at scale. I envision utilizing water as sacrificial electron donor. Hence, a simple and abundant cosubstrate will be used instead of the valuable cosubstrates mentioned above. This will be a completely new approach in (bio)catalysis. However, activating water for this purpose water is extremely difficult due to its kinetic and thermodynamic inertness. To solve this problem, I propose using visible light as external energy source and advanced chemical catalysts to facilitate water oxidation. The electrons liberated in this process will be made available (for the first time) to promote oxidoreductases-catalysed transformations.
BioAqua represents an entirely new paradigm in catalysis as I will bridge the gap between photocatalysis and biocatalysis enabling cleaner and more efficient reaction schemes.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Milja Pesic, Sébastien Jean-Paul Willot, Elena Fernández-Fueyo, Florian Tieves, Miguel Alcalde, Frank Hollmann Multienzymatic in situ hydrogen peroxide generation cascade for peroxygenase-catalysed oxyfunctionalisation reactions published pages: 101-104, ISSN: 0939-5075, DOI: 10.1515/znc-2018-0137 |
Zeitschrift für Naturforschung C 74/3-4 | 2020-02-18 |
| 2020 |
Hee-Jeong Cha, Se-Yeun Hwang, Da-Som Lee, Ravi Kumar Akula, Yong-Uk Kwon, Moritz Voß, Eva Schuiten, Uwe Bornscheuer, Frank Hollmann, Deok-Kun Oh, Jin-Byung Park Whole-Cell Photoenzymatic Cascades to Synthesize Long Chain Aliphatic Amines and Esters from Renewable Fatty Acids published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201915108 |
Angewandte Chemie International Edition | 2020-02-18 |
| 2019 |
Florian Tieves, Fabio Tonin, Elena Fernández-Fueyo, John M. Robbins, Bettina Bommarius, Andreas S. Bommarius, Miguel Alcalde, Frank Hollmann Energising the E-factor: The E+-factor published pages: 1311-1314, ISSN: 0040-4020, DOI: 10.1016/j.tet.2019.01.065 |
Tetrahedron 75/10 | 2020-02-18 |
| 2019 |
Florian Tieves, Sébastien Jean-Paul Willot, Morten Martinus Cornelis Harald van Schie, Marine Charlène Renée Rauch, Sabry Hamdy Hamed Younes, Wuyuan Zhang, JiaJia Dong, Patricia Gomez de Santos, John Mick Robbins, Bettina Bommarius, Miguel Alcalde, Andreas Sebastian Bommarius, Frank Hollmann Formate Oxidase (FOx) from Aspergillus oryzae : One Catalyst Enables Diverse H 2 O 2 -Dependent Biocatalytic Oxidation Reactions published pages: 7873-7877, ISSN: 1433-7851, DOI: 10.1002/anie.201902380 |
Angewandte Chemie International Edition 58/23 | 2020-02-18 |
| 2018 |
Frank Hollmann, Selin Kara, Diederik J. Opperman, Yonghua Wang Biocatalytic synthesis of lactones and lactams published pages: 3601-3610, ISSN: 1861-4728, DOI: 10.1002/asia.201801180 |
Chemistry - An Asian Journal 13/23 | 2020-02-18 |
| 2018 |
Georg T. Höfler, Elena Fernández-Fueyo, Milja Pesic, Sabry H. Younes, Eun-Gyu Choi, Yong H. Kim, Vlada B. Urlacher, Isabel W. C. E. Arends, Frank Hollmann A Photoenzymatic NADH Regeneration System published pages: 2344-2347, ISSN: 1439-4227, DOI: 10.1002/cbic.201800530 |
ChemBioChem 19/22 | 2020-02-18 |
| 2019 |
Jie Zhang, Fabio Tonin, Wuyuan Zhang, Peter-Leon Hagedoorn, Lloyd Mallée, Frank Hollmann ‘Clean’ hydrolase reactions using commercial washing powder published pages: 24039-24042, ISSN: 2046-2069, DOI: 10.1039/c9ra05828a |
RSC Advances 9/42 | 2020-02-18 |
| 2019 |
Jenő Gacs, Wuyuan Zhang, Tanja Knaus, Francesco G. Mutti, Isabel W.C.E. Arends, Frank Hollmann A Photo-Enzymatic Cascade to Transform Racemic Alcohols into Enantiomerically Pure Amines published pages: 305, ISSN: 2073-4344, DOI: 10.3390/catal9040305 |
Catalysts 9/4 | 2020-02-18 |
| 2015 |
Pablo DomÃnguez de MarÃa, Frank Hollmann On the (Un)greenness of Biocatalysis: Some Challenging Figures and Some Promising Options published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2015.01257 |
Frontiers in Microbiology 6 | 2020-02-18 |
| 2019 |
Sabry H. H. Younes, Florian Tieves, Dongming Lan, Yonghua Wang, Philipp Süss, Henrike Brundiek, Ron Wever, Frank Hollmann Chemoenzymatic Halocyclization of γ,δâ€Unsaturated Carboxylic Acids and Alcohols published pages: 97-101, ISSN: 1864-5631, DOI: 10.1002/cssc.201902240 |
ChemSusChem 13/1 | 2020-02-18 |
| 2020 |
Georg T. Höfler, Andrada But, Sabry H. H. Younes, Ron Wever, Caroline E. Paul, Isabel W. C. E. Arends, Frank Hollmann Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale published pages: , ISSN: 2168-0485, DOI: 10.1021/acssuschemeng.9b07494 |
ACS Sustainable Chemistry & Engineering | 2020-02-18 |
| 2019 |
Yunjian Ma, Yongru Li, Shahid Ali, Peilin Li, Wuyuan Zhang, Marine C. R. Rauch, Sébastien J.â€P. Willot, Doris Ribitsch, Young Hae Choi, Miguel Alcalde, Frank Hollmann, Yonghua Wang Natural Deep Eutectic Solvents as Performance Additives for Peroxygenase Catalysis published pages: , ISSN: 1867-3880, DOI: 10.1002/cctc.201901842 |
ChemCatChem | 2020-02-18 |
| 2019 |
Willot, Tieves, Girhard, Urlacher, Hollmann, de Gonzalo P450BM3-Catalyzed Oxidations Employing Dual Functional Small Molecules published pages: 567, ISSN: 2073-4344, DOI: 10.3390/catal9070567 |
Catalysts 9/7 | 2020-02-18 |
| 2020 |
M.C.R. Rauch, M.M.E. Huijbers, M. Pabst, C.E. Paul, M. Pešić, I.W.C.E. Arends, F. Hollmann Photochemical regeneration of flavoenzymes – An Old Yellow Enzyme case-study published pages: 140303, ISSN: 1570-9639, DOI: 10.1016/j.bbapap.2019.140303 |
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1868/1 | 2020-02-18 |
| 2019 |
Yunjian Ma, Peilin Li, Yongru Li, Sébastien J.â€P. Willot, Wuyuan Zhang, Doris Ribitsch, Young Hae Choi, Robert Verpoorte, Tianyu Zhang, Frank Hollmann, Yonghua Wang Natural Deep Eutectic Solvents as Multifunctional Media for the Valorization of Agricultural Wastes published pages: 1310-1315, ISSN: 1864-5631, DOI: 10.1002/cssc.201900043 |
ChemSusChem 12/7 | 2020-02-18 |
| 2019 |
Wuyuan Zhang, Elena Fernandez Fueyo, Frank Hollmann, Laura Leemans Martin, Milja Pesic, Rainer Wardenga, Matthias Höhne, Sandy Schmidt Combining Photo-Organo Redox- and Enzyme Catalysis Facilitates Asymmetric C-H Bond Functionalization published pages: 80-84, ISSN: 1434-193X, DOI: 10.1002/ejoc.201801692 |
European Journal of Organic Chemistry 2019/1 | 2020-02-18 |
| 2019 |
B. O. Burek, S. Bormann, F. Hollmann, J. Z. Bloh, D. Holtmann Hydrogen peroxide driven biocatalysis published pages: 3232-3249, ISSN: 1463-9262, DOI: 10.1039/c9gc00633h |
Green Chemistry 21/12 | 2020-02-18 |
| 2020 |
Yongru Li, Yunjian Ma, Peilin Li, Xizhen Zhang, Doris Ribitsch, Miguel Alcalde, Frank Hollmann, Yonghua Wang Enantioselective Sulfoxidation of Thioanisole by Cascading a Choline Oxidase and a Peroxygenase in the Presence of Natural Deep Eutectic Solvents published pages: 254-257, ISSN: 2192-6506, DOI: 10.1002/cplu.201900751 |
ChemPlusChem 85/1 | 2020-02-18 |
| 2019 |
Musa M. Musa, Frank Hollmann, Francesco G. Mutti Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods published pages: 5487-5503, ISSN: 2044-4753, DOI: 10.1039/c9cy01539f |
Catalysis Science & Technology 9/20 | 2020-02-18 |
| 2019 |
Laia Josa-Culleré, Antti Lahdenperä, Aubert Ribaucourt, Georg Höfler, Serena Gargiulo, Yuan-Yang Liu, Jian-He Xu, Jennifer Cassidy, Francesca Paradisi, Diederik Opperman, Frank Hollmann, Caroline Paul Synthetic Biomimetic Coenzymes and Alcohol Dehydrogenases for Asymmetric Catalysis published pages: 207, ISSN: 2073-4344, DOI: 10.3390/catal9030207 |
Catalysts 9/3 | 2020-02-18 |
| 2017 |
Milja Pesic, Elena Fernández-Fueyo, Frank Hollmann Characterization of the Old Yellow Enzyme Homolog from Bacillus subtilis (YqjM) published pages: 3866-3871, ISSN: 2365-6549, DOI: 10.1002/slct.201700724 |
ChemistrySelect 2/13 | 2019-06-06 |
| 2018 |
Wuyuan Zhang, Frank Hollmann Nonconventional regeneration of redox enzymes – a practical approach for organic synthesis? published pages: 7281-7289, ISSN: 1359-7345, DOI: 10.1039/C8CC02219D |
Chemical Communications 54/53 | 2019-06-06 |
| 2016 |
Dirk Holtmann, Frank Hollmann The Oxygen Dilemma: A Severe Challenge for the Application of Monooxygenases? published pages: 1391-1398, ISSN: 1439-4227, DOI: 10.1002/cbic.201600176 |
ChemBioChem 17/15 | 2019-06-06 |
| 2017 |
Wuyuan Zhang, Bastien O. Burek, Elena Fernández-Fueyo, Miguel Alcalde, Jonathan Z. Bloh, Frank Hollmann Selective Activation of C−H Bonds in a Cascade Process Combining Photochemistry and Biocatalysis published pages: 15451-15455, ISSN: 1433-7851, DOI: 10.1002/anie.201708668 |
Angewandte Chemie International Edition 56/48 | 2019-06-06 |
| 2018 |
JiaJia Dong, Elena Fernández-Fueyo, Frank Hollmann, Caroline E. Paul, Milja Pesic, Sandy Schmidt, Yonghua Wang, Sabry Younes, Wuyuan Zhang Biocatalytic Oxidation Reactions: A Chemist\'s Perspective published pages: 9238-9261, ISSN: 1433-7851, DOI: 10.1002/anie.201800343 |
Angewandte Chemie International Edition 57/30 | 2019-06-06 |
| 2016 |
Elena Fernández-Fueyo, Yan Ni, Alvaro Gomez Baraibar, Miguel Alcalde, Lukas M. van Langen, Frank Hollmann Towards preparative peroxygenase-catalyzed oxyfunctionalization reactions in organic media published pages: 347-352, ISSN: 1381-1177, DOI: 10.1016/j.molcatb.2016.09.013 |
Journal of Molecular Catalysis B: Enzymatic 134 | 2019-06-06 |
| 2017 |
Wuyuan Zhang, Jenő Gacs, Isabel W. C. E. Arends, Frank Hollmann Selective Photooxidation Reactions using Water-Soluble Anthraquinone Photocatalysts published pages: 3821-3826, ISSN: 1867-3880, DOI: 10.1002/cctc.201700779 |
ChemCatChem 9/20 | 2019-06-06 |
| 2017 |
Yonghua Wang, Dongming Lan, Rabia Durrani, Frank Hollmann Peroxygenases en route to becoming dream catalysts. What are the opportunities and challenges? published pages: 1-9, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2016.10.007 |
Current Opinion in Chemical Biology 37 | 2019-06-06 |
| 2017 |
M. Rauch, S. Schmidt, I. W. C. E. Arends, K. Oppelt, S. Kara, F. Hollmann Photobiocatalytic alcohol oxidation using LED light sources published pages: 376-379, ISSN: 1463-9262, DOI: 10.1039/C6GC02008A |
Green Chem. 19/2 | 2019-06-06 |
| 2017 |
Wuyuan Zhang, Anna Bariotaki, Ioulia Smonou, Frank Hollmann Visible-light-driven photooxidation of alcohols using surface-doped graphitic carbon nitride published pages: 2096-2100, ISSN: 1463-9262, DOI: 10.1039/c7gc00539c |
Green Chemistry 19/9 | 2019-06-06 |
| 2015 |
Yan Ni, Frank Hollmann Artificial Photosynthesis: Hybrid Systems published pages: , ISSN: , DOI: 10.1007/10_2015_5010 |
Advances in Biochemical Engineering/Biotechnology | 2019-06-06 |
| 2017 |
Sabry Younes, Yan Ni, Sandy Schmidt, Wolfgang Kroutil, Frank Hollmann Alcohol dehydrogenases catalyze the reduction of thioesters published pages: , ISSN: 1867-3880, DOI: 10.1002/cctc.201700165 |
ChemCatChem | 2019-06-06 |
| 2018 |
Wuyuan Zhang, Elena Fernández-Fueyo, Yan Ni, Morten van Schie, Jenö Gacs, Rokus Renirie, Ron Wever, Francesco G. Mutti, Dörte Rother, Miguel Alcalde, Frank Hollmann Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalizations published pages: 55-62, ISSN: 2520-1158, DOI: 10.1038/s41929-017-0001-5 |
Nature Catalysis 1/1 | 2019-06-06 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BIOAQUA" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "BIOAQUA" are provided by the European Opendata Portal: CORDIS opendata.