#	Pagina
attuale pagina	/open-h2020/projects/198063/index.html

Opendata, web and dolomites

LocalAdaptation SIGNED

Detecting Local Adaptation with Climate-Informed Spatial Genetic Models

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

LocalAdaptation project word cloud

Explore the words cloud of the LocalAdaptation project. It provides you a very rough idea of what is the project "LocalAdaptation" about.

populations hard genomes time hypotheses environment geographically resource detecting distinguish investigation population anatomically detected signals null integrating modern isolate individuals signature drivers species formally noisy applicable diversity space ancient signatures expansions cisgem leave localised sequencing paleoclimate datasets model speciation shape framework informed movements neutral tools fitness strength lines spatial accurate humans background generate quantifying fidelity genetic demography sizes explicit climate decreasing reconstructions influence reconstruct turn paleovegetation patterns organisms models thanks data genomic local whereby genotyping exhibit demographic quantify will additional

Project "LocalAdaptation" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙999˙839 €
EC max contribution	1˙999˙839 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	1˙999˙839.00

Map

Project objective

Local adaptation, whereby individuals of a population exhibit higher fitness in their local environment compared to that experienced by other populations, has the potential to shape the distribution of genetic diversity and influence speciation. However, detecting and quantifying the extent of local adaptation is challenging, since neutral demographic processes can leave signatures which are hard to distinguish from those of local selection. In this project, I propose to quantify the extent of local adaptation in Anatomically Modern Humans by using climate-informed spatial genetic models (CISGeM) to reconstruct past population sizes, local movements, and range expansions, and thus provide a null model against which the signature of geographically-localised selection can be detected. In CISGeM, demography is affected by local resource availability, which in turn is defined by paleoclimate and paleovegetation reconstructions. By using these additional lines of evidence, it is possible to generate accurate demographic reconstructions for any number of populations, as well as integrating information from both modern and ancient genomes. Such spatially-explicit reconstructions are key for defining the expected neutral patterns due to complex demography, and thus allow us to isolate the signals of selection from this noisy background with high fidelity. The availability of paleoclimate reconstructions also enables formally testing hypotheses about the drivers of selection, integrating the changes in the strength of selection through space and time. While this project will be focused on Anatomically Modern Humans, the framework that I will develop will be applicable to the investigation of local adaptation from genomic data in any species. Such tools are very timely, given the ever-increasing availability of large genetic datasets thanks to the decreasing cost of genotyping and sequencing in both model and non-model organisms.

Publications

List of publications.
year	authors and title	journal	last update
2017	Liisa Loog, Mark G. Thomas, Ross Barnett, Richard Allen, Naomi Sykes, Ptolemaios D. Paxinos, OphÃ©lie Lebrasseur, Keith Dobney, Joris Peters, Andrea Manica, Greger Larson, Anders Eriksson Inferring Allele Frequency Trajectories from Ancient DNA Indicates That Selection on a Chicken Gene Coincided with Changes in Medieval Husbandry Practices published pages: 1981-1990, ISSN: 0737-4038, DOI: 10.1093/molbev/msx142	Molecular Biology and Evolution 34/8	2020-04-06
2017	Martin Sikora, Andaine Seguin-Orlando, Vitor C. Sousa, Anders Albrechtsen, Thorfinn Korneliussen, Amy Ko, Simon Rasmussen, Isabelle Dupanloup, Philip R. Nigst, Marjolein D. Bosch, Gabriel Renaud, Morten E. Allentoft, Ashot Margaryan, Sergey V. Vasilyev, Elizaveta V. Veselovskaya, Svetlana B. Borutskaya, Thibaut Deviese, Dan Comeskey, Tom Higham, Andrea Manica, Robert Foley, David J. Meltzer, Rasmus Nielsen, Laurent Excoffier, Marta Mirazon Lahr, Ludovic Orlando, Eske Willerslev Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers published pages: 659-662, ISSN: 0036-8075, DOI: 10.1126/science.aao1807	Science 358/6363	2020-04-06
2017	Michela Leonardi, Guido Barbujani, Andrea Manica An earlier revolution: genetic and genomic analyses reveal pre-existing cultural differences leading to Neolithization published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-03717-6	Scientific Reports 7/1	2020-04-06
2018	C. L. Scheib, Hongjie Li, Tariq Desai, Vivian Link, Christopher Kendall, Genevieve Dewar, Peter William Griffith, Alexander MÃ¶rseburg, John R. Johnson, Amiee Potter, Susan L. Kerr, Phillip Endicott, John Lindo, Marc Haber, Yali Xue, Chris Tyler-Smith, Manjinder S. Sandhu, Joseph G. Lorenz, Tori D. Randall, Zuzana Faltyskova, Luca Pagani, Petr Danecek, Tamsin C. Oâ€™Connell, Patricia Martz, Alan S. Boraas, Brian F. Byrd, Alan Leventhal, Rosemary Cambra, Ronald Williamson, Louis Lesage, Brian Holguin, Ernestine Ygnacio-De Soto, JohnTommy Rosas, Mait Metspalu, Jay T. Stock, Andrea Manica, Aylwyn Scally, Daniel Wegmann, Ripan S. Malhi, Toomas Kivisild Ancient human parallel lineages within North America contributed to a coastal expansion published pages: 1024-1027, ISSN: 0036-8075, DOI: 10.1126/science.aar6851	Science 360/6392	2020-04-06
2017	Gloria GonzÃ¡lez-Fortes, Eppie R. Jones, Emma Lightfoot, Clive Bonsall, Catalin Lazar, Aurora Grandal-dâ€™Anglade, MarÃa Dolores Garralda, Labib Drak, Veronika Siska, Angela Simalcsik, Adina BoroneanÅ£, Juan RamÃ³n Vidal RomanÃ, Marcos Vaqueiro RodrÃguez, Pablo Arias, Ron Pinhasi, Andrea Manica, Michael Hofreiter Paleogenomic Evidence for Multi-generational Mixing between Neolithic Farmers and Mesolithic Hunter-Gatherers in the Lower Danube Basin published pages: 1801-1810.e10, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.05.023	Current Biology 27/12	2020-04-06
2017	Liisa Loog, Marta MirazÃ³n Lahr, Mirna Kovacevic, Andrea Manica, Anders Eriksson, Mark G. Thomas Estimating mobility using sparse data: Application to human genetic variation published pages: 12213-12218, ISSN: 0027-8424, DOI: 10.1073/pnas.1703642114	Proceedings of the National Academy of Sciences 114/46	2020-04-06
2018	Kevin G. Daly, Pierpaolo Maisano Delser, Victoria E. Mullin, Amelie Scheu, Valeria Mattiangeli, Matthew D. Teasdale, Andrew J. Hare, Joachim Burger, Marta Pereira Verdugo, Matthew J. Collins, Ron Kehati, Cevdet Merih Erek, Guy Bar-Oz, FranÃ§ois Pompanon, Tristan Cumer, Canan Ã‡akÄ±rlar, Azadeh Fatemeh Mohaseb, Delphine Decruyenaere, Hossein Davoudi, Ã–zlem Ã‡evik, Gary Rollefson, Jean-Denis Vigne, Roya Khazaeli, Homa Fathi, Sanaz Beizaee Doost, Roghayeh Rahimi Sorkhani, Ali Akbar Vahdati, Eberhard W. Sauer, Hossein Azizi Kharanaghi, Sepideh Maziar, Boris Gasparian, Ron Pinhasi, Louise Martin, David Orton, Benjamin S. Arbuckle, Norbert Benecke, Andrea Manica, Liora Kolska Horwitz, Marjan Mashkour, Daniel G. Bradley Ancient goat genomes reveal mosaic domestication in the Fertile Crescent published pages: 85-88, ISSN: 0036-8075, DOI: 10.1126/science.aas9411	Science 361/6397	2020-04-06
2018	Michela Leonardi, Francesco Boschin, Konstantinos Giampoudakis, Robert M. Beyer, Mario Krapp, Robin Bendrey, Robert Sommer, Paolo Boscato, Andrea Manica, David Nogues-Bravo, Ludovic Orlando Late Quaternary horses in Eurasia in the face of climate and vegetation change published pages: eaar5589, ISSN: 2375-2548, DOI: 10.1126/sciadv.aar5589	Science Advances 4/7	2020-04-06
2018	Eleanor M.L. Scerri, Mark G. Thomas, Andrea Manica, Philipp Gunz, Jay T. Stock, Chris Stringer, Matt Grove, Huw S. Groucutt, Axel Timmermann, G. Philip Rightmire, Francesco dâ€™Errico, Christian A. Tryon, Nick A. Drake, Alison S. Brooks, Robin W. Dennell, Richard Durbin, Brenna M. Henn, Julia Lee-Thorp, Peter deMenocal, Michael D. Petraglia, Jessica C. Thompson, Aylwyn Scally, LounÃ¨s Chikhi Did Our Species Evolve in Subdivided Populations across Africa, and Why Does It Matter? published pages: 582-594, ISSN: 0169-5347, DOI: 10.1016/j.tree.2018.05.005	Trends in Ecology & Evolution 33/8	2020-04-06
2016	Anna-Sapfo Malaspinas, Michael C. Westaway, Craig Muller, Vitor C. Sousa, Oscar Lao, Isabel Alves, Anders BergstrÃ¶m, Georgios Athanasiadis, Jade Y. Cheng, Jacob E. Crawford, Tim H. Heupink, Enrico Macholdt, Stephan Peischl, Simon Rasmussen, Stephan Schiffels, Sankar Subramanian, Joanne L. Wright, Anders Albrechtsen, Chiara Barbieri, Isabelle Dupanloup, Anders Eriksson, Ashot Margaryan, Ida Moltke, Irina Pugach, Thorfinn S. Korneliussen, Ivan P. Levkivskyi, J. VÃctor Moreno-Mayar, Shengyu Ni, Fernando Racimo, Martin Sikora, Yali Xue, Farhang A. Aghakhanian, Nicolas Brucato, SÃ¸ren Brunak, Paula F. Campos, Warren Clark, Sturla EllingvÃ¥g, Gudjugudju Fourmile, Pascale Gerbault, Darren Injie, George Koki, Matthew Leavesley, Betty Logan, Aubrey Lynch, Elizabeth A. Matisoo-Smith, Peter J. McAllister, Alexander J. Mentzer, Mait Metspalu, Andrea B. Migliano, Les Murgha, Maude E. Phipps, William Pomat, Doc Reynolds, Francois-Xavier Ricaut, Peter Siba, Mark G. Thomas, Thomas Wales, Colleen Maâ€™run Wall, Stephen J. Oppenheimer, Chris Tyler-Smith, Richard Durbin, Joe Dortch, Andrea Manica, Mikkel H. Schierup, Robert A. Foley, Marta MirazÃ³n Lahr, Claire Bowern, Jeffrey D. Wall, Thomas Mailund, Mark Stoneking, Rasmus Nielsen, Manjinder S. Sandhu, Laurent Excoffier, David M. Lambert, Eske Willerslev A genomic history of Aboriginal Australia published pages: 207-214, ISSN: 0028-0836, DOI: 10.1038/nature18299	Nature 538/7624	2020-04-06
2016	Luca Pagani, Daniel John Lawson, Evelyn Jagoda, Alexander MÃ¶rseburg, Anders Eriksson, Mario Mitt, Florian Clemente, Georgi Hudjashov, Michael DeGiorgio, Lauri Saag, Jeffrey D. Wall, Alexia Cardona, Reedik MÃ¤gi, Melissa A. Wilson Sayres, Sarah Kaewert, Charlotte Inchley, Christiana L. Scheib, Mari JÃ¤rve, Monika Karmin, Guy S. Jacobs, Tiago Antao, Florin Mircea Iliescu, Alena Kushniarevich, Qasim Ayub, Chris Tyler-Smith, Yali Xue, Bayazit Yunusbayev, Kristiina Tambets, Chandana Basu Mallick, Lehti Saag, Elvira Pocheshkhova, George Andriadze, Craig Muller, Michael C. Westaway, David M. Lambert, Grigor Zoraqi, Shahlo Turdikulova, Dilbar Dalimova, Zhaxylyk Sabitov, Gazi Nurun Nahar Sultana, Joseph Lachance, Sarah Tishkoff, Kuvat Momynaliev, Jainagul Isakova, Larisa D. Damba, Marina Gubina, Pagbajabyn Nymadawa, Irina Evseeva, Lubov Atramentova, Olga Utevska, FranÃ§ois-Xavier Ricaut, Nicolas Brucato, Herawati Sudoyo, Thierry Letellier, Murray P. Cox, Nikolay A. Barashkov, Vedrana Å karo, Lejla MulahasanovicÂ´, Dragan Primorac, Hovhannes Sahakyan, Maru Mormina, Christina A. Eichstaedt, Daria V. Lichman, Syafiq Abdullah, Gyaneshwer Chaubey, Joseph T. S. Wee, Evelin Mihailov, Alexandra Karunas, Sergei Litvinov, Rita Khusainova, Natalya Ekomasova, Vita Akhmetova, Irina Khidiyatova, Damir MarjanoviÄ‡, Levon Yepiskoposyan, Doron M. Behar, Elena Balanovska, Andres Metspalu, Miroslava Derenko, Boris Malyarchuk, Mikhail Voevoda, Sardana A. Fedorova, Ludmila P. Osipova, Marta MirazÃ³n Lahr, Pascale Gerbault, Matthew Leavesley, Andrea Bamberg Migliano, Michael Petraglia, Oleg Balanovsky, Elza K. Khusnutdinova, Ene Metspalu, Mark G. Thomas, Andrea Manica, Rasmus Nielsen, Richard Villems, Eske Willerslev, Toomas Kivisild, Mait Metspalu Genomic analyses inform on migration events during the peopling of Eurasia published pages: 238-242, ISSN: 0028-0836, DOI: 10.1038/nature19792	Nature 538/7624	2020-04-06
2015	Eppie R. Jones, Gloria Gonzalez-Fortes, Sarah Connell, Veronika Siska, Anders Eriksson, Rui Martiniano, Russell L. McLaughlin, Marcos Gallego Llorente, Lara M. Cassidy, Cristina Gamba, Tengiz Meshveliani, Ofer Bar-Yosef, Werner MÃ¼ller, Anna Belfer-Cohen, Zinovi Matskevich, Nino Jakeli, Thomas F. G. Higham, Mathias Currat, David Lordkipanidze, Michael Hofreiter, Andrea Manica, Ron Pinhasi, Daniel G. Bradley Upper Palaeolithic genomes reveal deep roots of modern Eurasians published pages: 8912, ISSN: 2041-1723, DOI: 10.1038/ncomms9912	Nature Communications 6	2020-04-06
2015	M. G. Llorente, E. R. Jones, A. Eriksson, V. Siska, K. W. Arthur, J. W. Arthur, M. C. Curtis, J. T. Stock, M. Coltorti, P. Pieruccini, S. Stretton, F. Brock, T. Higham, Y. Park, M. Hofreiter, D. G. Bradley, J. Bhak, R. Pinhasi, A. Manica Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa published pages: 820-822, ISSN: 0036-8075, DOI: 10.1126/science.aad2879	Science 350/6262	2020-04-06
2017	Veronika Siska, Eppie Ruth Jones, Sungwon Jeon, Youngjune Bhak, Hak-Min Kim, Yun Sung Cho, Hyunho Kim, Kyusang Lee, Elizaveta Veselovskaya, Tatiana Balueva, Marcos Gallego-Llorente, Michael Hofreiter, Daniel G. Bradley, Anders Eriksson, Ron Pinhasi, Jong Bhak, Andrea Manica Genome-wide data from two early Neolithic East Asian individuals dating to 7700 years ago published pages: e1601877, ISSN: 2375-2548, DOI: 10.1126/sciadv.1601877	Science Advances 3/2	2020-04-06
2017	Eppie R. Jones, Gunita Zarina, Vyacheslav Moiseyev, Emma Lightfoot, Philip R. Nigst, Andrea Manica, Ron Pinhasi, Daniel G. Bradley The Neolithic Transition in the Baltic Was Not Driven by Admixture with Early European Farmers published pages: 576-582, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.12.060	Current Biology 27/4	2020-04-06
2016	M. Gallego-Llorente, S. Connell, E. R. Jones, D. C. Merrett, Y. Jeon, A. Eriksson, V. Siska, C. Gamba, C. Meiklejohn, R. Beyer, S. Jeon, Y. S. Cho, M. Hofreiter, J. Bhak, A. Manica, R. Pinhasi The genetics of an early Neolithic pastoralist from the Zagros, Iran published pages: , ISSN: 2045-2322, DOI: 10.1038/srep31326	Scientific Reports 6/1	2020-04-06

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LOCALADAPTATION" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LOCALADAPTATION" are provided by the European Opendata Portal: CORDIS opendata.