Explore the words cloud of the CaSR Biomedicine project. It provides you a very rough idea of what is the project "CaSR Biomedicine" about.
The following table provides information about the project.
Coordinator |
MEDIZINISCHE UNIVERSITAET WIEN
Organization address contact info |
Coordinator Country | Austria [AT] |
Project website | https://casr.meduniwien.ac.at/ |
Total cost | 3˙657˙194 € |
EC max contribution | 3˙657˙194 € (100%) |
Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
Code Call | H2020-MSCA-ITN-2015 |
Funding Scheme | MSCA-ITN-ETN |
Starting year | 2016 |
Duration (year-month-day) | from 2016-03-01 to 2020-02-29 |
Take a look of project's partnership.
The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer, which account for >25% of the global disease burden. The CaSR is a unique GPCR whose principal physiological ligand is the Ca2 ion; it is expressed almost ubiquitously; interacts with multiple Gα subtypes regulating highly divergent downstream signalling pathways, depending on the cellular context. The CaSR Biomedicine is a fully translational project that utilises the concept of a single molecule, the CaSR, influencing a range of physiological and disease processes, to develop a unique, strong multidisciplinary and intersectoral scientific training programme preparing 14 young scientists to become specialists in GPCR biology and signalling. The objectives of CaSR Biomedicine are: 1. Educate and train Early Stage Researchers to become highly innovative scientists to enhance their career perspective. 2. Elucidate ligand- and tissue-dependent differences in CaSR physiology by examining its functions at cellular level and thus to contribute to the understanding of GPCR signalling in general; 3. Assess how CaSR function is altered in AD, CVD, DM, sarcopenia, and cancer, and to find innovative CaSR-based therapeutic approaches for these major, age-related disorders. 4. Establish long-lasting interdisciplinary and intersectoral cooperation among researchers and between researchers and industry, to strengthen the European Research Area. Therefore the CaSR Biomedicine will investigate the complexity of CaSR signalling and function to identify CaSR-based therapeutic approaches to diseases linked to changes in CaSR expression or function (AD, CVD, DM, sarcopenia, and cancer).
Public domain of the webpage on-line | Websites, patent fillings, videos etc. | 2019-07-10 13:01:37 |
Vacancies advertised | Other | 2019-07-10 13:01:37 |
3rd ETN School held | Other | 2019-07-10 13:01:37 |
First newsletter | Other | 2019-07-10 13:01:37 |
Second Newsletter | Other | 2019-07-10 13:01:37 |
First ETN School held | Other | 2019-07-10 13:01:37 |
2nd ETN school held | Other | 2019-07-10 13:01:37 |
International CaSR Symposium | Other | 2019-07-10 13:01:37 |
Take a look to the deliverables list in detail: detailed list of CaSR Biomedicine deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Marta GarcÃa, Carlos Javier RodrÃguezâ€Hernández, Silvia Mateoâ€Lozano, Sara Pérezâ€Jaume, Eliana Gonçalvesâ€Alves, Cinzia Lavarino, Jaume Mora, Carmen Torres Parathyroid hormoneâ€like hormone plays a dual role in neuroblastoma depending on PTH 1R expression published pages: 1959-1975, ISSN: 1574-7891, DOI: 10.1002/1878-0261.12542 |
Molecular Oncology 13/9 | 2020-04-24 |
2020 |
Souvik Das, Philippe Clézardin, Said Kamel, Michel Brazier, Romuald Mentaverri The CaSR in Pathogenesis of Breast Cancer: A New Target for Early Stage Bone Metastases published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2020.00069 |
Frontiers in Oncology 10 | 2020-04-24 |
2019 |
Maria Lo Giudice, Balázs Mihalik, András Dinnyés, Julianna Kobolák The Nervous System Relevance of the Calcium Sensing Receptor in Health and Disease published pages: 2546, ISSN: 1420-3049, DOI: 10.3390/molecules24142546 |
Molecules 24/14 | 2019-08-29 |
2019 |
Iris Mos, Stine E. Jacobsen, Simon Foster, Hans Brauner-Osborne Calcium-sensing receptor internalization is β-arrestin-dependent and modulated by allosteric ligands published pages: mol.119.116772, ISSN: 0026-895X, DOI: 10.1124/mol.119.116772 |
Molecular Pharmacology | 2019-08-29 |
2016 |
Isabella Ellinger The Calcium-Sensing Receptor and the Reproductive System published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2016.00371 |
Frontiers in Physiology 7 | 2019-07-10 |
2018 |
Enikö Kallay Editorial: Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00413 |
Frontiers in Physiology 9 | 2019-07-10 |
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