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Opendata, web and dolomites

HaemMetabolome SIGNED

Deciphering the Metabolism of Haematological Cancers

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

HaemMetabolome project word cloud

Explore the words cloud of the HaemMetabolome project. It provides you a very rough idea of what is the project "HaemMetabolome" about.

computational niche metabolome omics screen disciplinary unravel regulation emphasis genome inhibitors cancers framework it haemmetabolism aberrations phenotypes proliferation biomedicine avenues cycle cell biomedical function vivo transcriptional data technologies xenograft personalised directed diseases mouse panel training samples performed understand medicine collectively library malignancies mechanisms vitro factorial regulatory libraries gene recognised hallmark link humanized opening homeostasis cellular deregulated integration metabolism student validation preclinical lines ultimate models central primary realised drug shrna metabolic regulators discovery patient haematological cancer

Project "HaemMetabolome" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://haemmetabolome-itn.eu
Total cost	2˙572˙664 €
EC max contribution	2˙572˙664 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-EJD
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	coordinator	819˙863.00
2	UNIVERSITAT DE BARCELONA UNIVERSITAT DE BARCELONA Organization address address: GRAN VIA DE LES CORTS CATALANES 585 city: BARCELONA postcode: 8007 website: http://www.ub.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	743˙618.00
3	ACADEMISCH ZIEKENHUIS GRONINGEN ACADEMISCH ZIEKENHUIS GRONINGEN Organization address address: HANZEPLEIN 1 city: GRONINGEN postcode: 9713 GZ website: www.umcg.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	510˙748.00
4	JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN Organization address address: THEODOR W ADORNO PLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 website: www.uni-frankfurt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	498˙432.00
5	BRUKER BIOSPIN GMBH BRUKER BIOSPIN GMBH Organization address address: Am Silberstreifen city: RHEINSTETTEN postcode: 76287 website: www.bruker-biospin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (RHEINSTETTEN)	partner	0.00
6	LIFEGLIMMER GMBH LIFEGLIMMER GMBH Organization address address: MARKELSTRASSE 38 city: BERLIN postcode: 12163 website: www.lifeglimmer.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	partner	0.00
7	TavarGenix TavarGenix Organization address address: n.a. city: Heidelberg postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Heidelberg)	partner	0.00

Map

Project objective

It has long been realised that metabolism is central to cellular development, proliferation and homeostasis. Collectively, aberrations in metabolism are now recognised as a major hallmark of cancer, opening new avenues for personalised medicine. As haematological malignancies are multi-factorial diseases, our main emphasis will be on the integration of biomedical multi-omics data and computational systems modelling with the ultimate aim to understand metabolic regulation in haematological cancers. HaemMetabolism is design to unravel the regulatory mechanisms that link cell cycle control and metabolism. For this we will screen a panel of haematological cancer cell lines for the metabolic phenotypes and against a library of inhibitors. Gene-function analyses will be performed using shRNA libraries directed against key metabolome regulators. Validation will occur in primary patient samples in vitro and in vivo in preclinical humanized niche xenograft mouse models. A systems biomedicine approach will be integrated build genome-scale transcriptional models that explain deregulated metabolic pathways relevant for the development of haematological malignancies. This work will not only open new avenues for drug discovery but will also provide a multi-disciplinary framework for student training in biomedical technologies.

Deliverables

List of deliverables.
Organization of WS1	Documents, reports	2019-07-09 17:07:47
Recruitment ESR	Documents, reports	2019-07-09 17:07:48
Report on contribution towards conferences and scientific publications	Websites, patent fillings, videos etc.	2019-07-09 17:07:48
Organization of ATC1	Documents, reports	2019-07-09 17:07:47
Newsletters 1	Websites, patent fillings, videos etc.	2019-07-09 17:07:48
Newsletters 2	Websites, patent fillings, videos etc.	2019-07-09 17:07:48
Website set-up	Websites, patent fillings, videos etc.	2019-07-09 17:07:47

Take a look to the deliverables list in detail: detailed list of HaemMetabolome deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Raquel Saborano, Zuhal Eraslan, Jennie Roberts, Farhat L. Khanim, Patricia F. Lalor, Michelle A. C. Reed, Ulrich L. GÃ¼nther A framework for tracer-based metabolism in mammalian cells by NMR published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37525-3	Scientific Reports 9/1	2020-03-24
2020	Islam Alshamleh, Nina Krause, Christian Richter, Nina Kurrle, Hubert Serve, Ulrich L. GÃ¼nther, Harald Schwalbe Real-Time NMR Spectroscopy for Studying Metabolism published pages: 2304-2308, ISSN: 1433-7851, DOI: 10.1002/anie.201912919	Angewandte Chemie International Edition 59/6	2020-03-24
2019	Kreitz, SchÃ¶nfeld, Seibert, Stolp, Alshamleh, Oellerich, Steffen, Schwalbe, SchnÃ¼tgen, Kurrle, Serve Metabolic Plasticity of Acute Myeloid Leukemia published pages: 805, ISSN: 2073-4409, DOI: 10.3390/cells8080805	Cells 8/8	2019-10-28

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The information about "HAEMMETABOLOME" are provided by the European Opendata Portal: CORDIS opendata.