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HippAchoMod SIGNED

Deciphering the cholinergic modulation of the hippocampal place code.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 HippAchoMod project word cloud

Explore the words cloud of the HippAchoMod project. It provides you a very rough idea of what is the project "HippAchoMod" about.

active    technologies    fundamental    questions    basal    independent    acquisition    responsive    alter    environment    reorganization    electrophysiological    opsins    inputs    emergence    principal    despite    stimuli    decades    subcortical    input    cocktail    sequences    cognitive    stabilization    place    home    skills    surroundings    deficits    monitor    code    representing    acetylcholine    inform    contributes    starting    accomplishing    optimal    storage    released    function    ensembles    dependent    hippocampus    group    neuron    behaving    animal    indispensable    breakthroughs    opened    conversion    intense    behavioural    possibilities    amalgamation    salient    manipulation    selective    deterioration    impairments    external    recording    leads    edge    cholinergic    severe    technological    determined    modulatory    microbial    modulation    tracking    ach    manifested    internal    representations    environmental    combine    light    debilitating    outlined    network    renders    acquainted    critical    co    manipulating    firing    governing    neuronal    forebrain    hippocampal    optogenetic    expanding    cutting    cortical    latest    types    decipher    cells    neurons    mice   

Project "HippAchoMod" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES 

Organization address
address: Szigony utca 43
city: Budapest
postcode: 1083
website: www.koki.hu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Hungary [HU]
 Total cost 245˙250 €
 EC max contribution 245˙250 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-08-08   to  2019-08-07

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES HU (Budapest) coordinator 245˙250.00
2    NEW YORK UNIVERSITY US (NEW YORK) partner 0.00

Map

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 Project objective

Acetylcholine released by cholinergic neurons in the basal forebrain is a critical component of the modulatory cocktail governing the emergence, stabilization and reorganization of cortical ensembles of co-active neurons representing the environment. In the hippocampus, ACh renders the state of the network optimal for the acquisition of novel information. Deterioration of cholinergic modulation leads to severe deficits in hippocampal function manifested as debilitating cognitive impairments. Despite decades of intense research fundamental questions are still open about the cholinergic modulation of hippocampal information processing: i) how is the behaviour-dependent firing of different neuron types determined by ACh? ii) how does ACh contribute to the emergence of the spatially selective firing of principal cells, their amalgamation into sequences representing the surroundings of the animal and the storage of “relevant” sequences? iii) how does ACh alter the place code in response to salient environmental stimuli? Technological breakthroughs of the past years have opened the possibilities of addressing these long-standing questions about cholinergic modulation. Thus, I aim to combine the latest electrophysiological recording, optogenetic manipulation and behavioural tracking methods to monitor hippocampal neuronal ensembles in freely behaving mice while manipulating the cholinergic input of the hippocampus by light-responsive microbial opsins. Results of the proposed research programme will decipher the role of ACh in hippocampal information processing and inform us how subcortical modulation contributes to the conversion of external inputs from the environment to internal representations. By accomplishing the programme outlined in the proposal I will be acquainted with the cutting edge technologies as well as skills indispensable for starting my independent research group and expanding the research potential of my home institute.

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The information about "HIPPACHOMOD" are provided by the European Opendata Portal: CORDIS opendata.

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