Opendata, web and dolomites

CholangioConcept SIGNED

Functional in vivo analysis of cholangiocarcinoma development, progression and metastasis.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CholangioConcept project word cloud

Explore the words cloud of the CholangioConcept project. It provides you a very rough idea of what is the project "CholangioConcept" about.

identification    clear    functionally    option    direct    ccc    emerged    vulnerabilities    oncogenomic    dissect    gut    complexity    expertises    screening    influences    emphasis    tumors    microbiome    altered    strategies    chimaeric    heterogeneity    erc    metabolism    adult    shrna    metastatic    inevitably    mouse    urgently    ing    sharply    bile    driving    therapeutic    surgical    resistance    harbor    aggressive    cholangiocarcinoma    stable    characterization    solid    advantage    genetic    yield    hepatocytes    unclear    insights    innovative    systemic    incidence    vivo    intrahepatic    regimen    data    therapies    primary    frequent    lifestyle    treatment    models    cancer    diagnosis    tumor    drugs    hepatic    icc    rates    metastasis    irresectable    mosaic    liver    hallmarks    cholangiocarcinogenesis    functional    profiling    employ    molecular    becomes    cytotoxic    envision    exists    health    translational    therapy    progression    develops    time    poorly    discussed    duct    mechanisms    kras    western    curative    resection   

Project "CholangioConcept" data sheet

The following table provides information about the project.

Coordinator
EBERHARD KARLS UNIVERSITAET TUEBINGEN 

Organization address
address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074
website: www.uni-tuebingen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙998˙898 €
 EC max contribution 1˙998˙898 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) coordinator 1˙998˙898.00

Map

 Project objective

Genetic heterogeneity and complexity are hallmarks of metastatic solid tumors and therapy resistance inevitably develops upon treatment with cytotoxic drugs or molecular targeted therapies. Cholangiocarcinoma (CCC, or bile duct cancer) represents the second most frequent primary liver tumor and has emerged as a health problem with sharply increasing incidence rates, in particular of intrahepatic CCC (ICC). The reason for increased CCC incidence remains unclear, but influences of western lifestyle and a resulting altered hepatic metabolism have been discussed. Surgical resection represents the only curative option for the treatment of CCC, however, many tumors are irresectable at the time of diagnosis. CCC represents a highly aggressive and metastatic tumor type and currently no effective systemic therapy regimen exists. The overall molecular mechanisms driving CCC formation and progression remain poorly characterized and it thus becomes clear that a detailed molecular characterization of cholangiocarcinogenesis and the identification of robust therapeutic targets for CCC treatment are urgently needed. Taking advantage of our strong expertises in chimaeric (mosaic) liver cancer mouse models and stable in vivo shRNA technology, we here propose a comprehensive and innovative approach to i) dissect molecular mechanisms of cholangiocarcinogenesis, with a particular emphasis on Kras driven ICC development from adult hepatocytes and oncogenomic profiling of ICC metastasis, ii) to employ direct in vivo shRNA screening to functionally identify new therapeutic targets for CCC treatment and iii) to characterize the role of the gut microbiome for CCC progression and metastasis. We envision this ERC-funded project will yield important new insights into the molecular mechanisms of CCC development, progression and metastasis. As our work comprises direct and functional strategies to identify new vulnerabilities in CCC, the obtained data harbor a very high translational potential.

 Publications

year authors and title journal last update
List of publications.
2018 Marco Seehawer, Florian Heinzmann, Luana D’Artista, Jule Harbig, Pierre-François Roux, Lisa Hoenicke, Hien Dang, Sabrina Klotz, Lucas Robinson, Grégory Doré, Nir Rozenblum, Tae-Won Kang, Rishabh Chawla, Thorsten Buch, Mihael Vucur, Mareike Roth, Johannes Zuber, Tom Luedde, Bence Sipos, Thomas Longerich, Mathias Heikenwälder, Xin Wei Wang, Oliver Bischof, Lars Zender
Necroptosis microenvironment directs lineage commitment in liver cancer
published pages: 69-75, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0519-y
Nature 562/7725 2019-04-18
2018 Laura Faletti, Lukas Peintner, Simon Neumann, Sandra Sandler, Thomas Grabinger, Sabine Mac Nelly, Irmgard Merfort, Chun-Hao Huang, Darjus Tschaharganeh, Tae-Won Kang, Florian Heinzmann, Luana D’Artista, Ulrich Maurer, Thomas Brunner, Scott Lowe, Lars Zender, Christoph Borner
TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation
published pages: n/a, ISSN: 2041-4889, DOI: 10.1038/s41419-018-0935-9
Cell Death & Disease 9/9 2019-04-18

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CHOLANGIOCONCEPT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CHOLANGIOCONCEPT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Life-Inspired (2019)

Life-inspired complex molecular systems controlled by enzymatic reaction networks

Read More  

DISSECT (2020)

DISSECT: Evidence in International Human Rights Adjudication

Read More  

GAIA (2020)

A Genomic and Macroevolutionary Approach to Studying Diversification in an Insect-Plant Arms Race

Read More