DEPICODE SIGNED
Decoding the epigenetic signature of memory function in health and disease
Total Cost €
0EC-Contrib. €
0Partnership
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0DEPICODE project word cloud
Explore the words cloud of the DEPICODE project. It provides you a very rough idea of what is the project "DEPICODE" about.
Project "DEPICODE" data sheet
The following table provides information about the project.
| Coordinator |
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Total cost | 1˙729˙125 € |
| EC max contribution | 1˙729˙125 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-09-01 to 2021-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV | DE (BONN) | coordinator | 1˙729˙125.00 |
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Project objective
The emerging field of neuroepigenetics investigates processes such as histone-acetylation in the context of neuronal plasticity, memory function and brain diseases. My group has significantly contributed to this novel research field. It is however fair to say that the role of “epigenetics” in memory function is still met with some skepticism in the neurosciences, which is in part due to the fact that many of the current studies have been describing phenomena and mechanistic data to explain how epigenetic processes control memory function in health and disease are comparatively sparse. The major objective of this research proposal is to address this issue and help to consolidate the field of neuroepigenetics by providing insight to the mechanisms by which epigenetic processes contribute to memory formation under physiological and pathological conditions. More specifically I will ask how the epigenetic code is translated into cellular changes that mediate memory formation in health and disease and how can epigenetic mechanisms contribute to the transmission of cognitive phenotypes even across generations. Our results will not only provide import insight to the mechanisms that underlie memory formation but will also lay the basis for the development of novel and improved therapies for age-related cognitive disorders.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Ann-Christin Wendeln, Karoline Degenhardt, Lalit Kaurani, Michael Gertig, Thomas Ulas, Gaurav Jain, Jessica Wagner, Lisa M. Häsler, Katleen Wild, Angelos Skodras, Thomas Blank, Ori Staszewski, Moumita Datta, Tonatiuh Pena Centeno, Vincenzo Capece, Md. Rezaul Islam, Cemil Kerimoglu, Matthias Staufenbiel, Joachim L. Schultze, Marc Beyer, Marco Prinz, Mathias Jucker, André Fischer, Jonas J. Neher Innate immune memory in the brain shapes neurological disease hallmarks published pages: 332-338, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0023-4 |
Nature 556/7701 | 2019-12-12 |
| 2018 |
Eva Benito, Cemil Kerimoglu, Binu Ramachandran, Tonatiuh Pena-Centeno, Gaurav Jain, Roman Manuel Stilling, Md Rezaul Islam, Vincenzo Capece, Qihui Zhou, Dieter Edbauer, Camin Dean, André Fischer RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment published pages: 546-554, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.03.059 |
Cell Reports 23/2 | 2019-12-12 |
| 2018 |
Ana Martinez Hernandez, Hendrik Urbanke, Alan L Gillman, Joon Lee, Sergey Ryazanov, Hope Y Agbemenyah, Eva Benito, Gaurav Jain, Lalit Kaurani, Gayane Grigorian, Andrei Leonov, Nasrollah Rezaeiâ€Ghaleh, Petra Wilken, Fernando Teran Arce, Jens Wagner, Martin Fuhrman, Mario Caruana, Angelique Camilleri, Neville Vassallo, Markus Zweckstetter, Roland Benz, Armin Giese, Anja Schneider, Martin Korte, Ratnesh Lal, Christian Griesinger, Gregor Eichele, Andre Fischer The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology published pages: 32-47, ISSN: 1757-4676, DOI: 10.15252/emmm.201707825 |
EMBO Molecular Medicine 10/1 | 2019-12-12 |
| 2017 |
Cemil Kerimoglu, M. Sadman Sakib, Gaurav Jain, Eva Benito, Susanne Burkhardt, Vincenzo Capece, Lalit Kaurani, Rashi Halder, Roberto Carlos AgÃs-Balboa, Roman Stilling, Hendrik Urbanke, Andrea Kranz, A. Francis Stewart, Andre Fischer KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions published pages: 538-548, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.06.072 |
Cell Reports 20/3 | 2019-12-12 |
| 2017 |
Roberto Carlos AgÃsâ€Balboa, Paulo S Pinheiro, Nelson Rebola, Cemil Kerimoglu, Eva Benito, Michael Gertig, Sanaz Bahariâ€Javan, Gaurav Jain, Susanne Burkhardt, Ivana Delalle, Alexander Jatzko, Markus Dettenhofer, Patricia A Zunszain, Andrea Schmitt, Peter Falkai, Julius C Pape, Elisabeth B Binder, Christophe Mulle, Andre Fischer, Farahnaz Sananbenesi Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia published pages: 2815-2828, ISSN: 0261-4189, DOI: 10.15252/embj.201796821 |
The EMBO Journal 36/19 | 2019-12-12 |
| 2017 |
E Benito, B Ramachandran, H Schroeder, G Schmidt, H Urbanke, S Burkhardt, V Capece, C Dean, A Fischer The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice published pages: e1239, ISSN: 2158-3188, DOI: 10.1038/tp.2017.202 |
Translational Psychiatry 7/9 | 2019-12-12 |
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